@article{ed66be30d04411dd9908000ea68e967b,
title = "Reactivity to patch tests with nickel sulfate and fragrance mix in infants",
abstract = "The pattern of patch test reactivity to nickel sulfate and fragrance mix was studied with respect to patch test performance, reproducibility and clinical relevance in a population of unselected infants followed prospectively from birth to 18 months of age. TRUE Testtrade mark patches with nickel sulfate in 3 concentrations, 200, 66 and 22 microg/cm(2), and fragrance mix 430 microg/cm(2) were used. A likely case of nickel sensitivity was defined as a reproducible positive reaction with at least homogeneous erythema and palpable infiltration occurring at least 2x and present at both the 12 and 18 months follow-up. 543 infants (268 girls and 275 boys) were tested at least 1x, 304 were tested at both 12 and 18 months. The prevalence of a reproducible positive reaction to nickel was 8.6\% (20 girls and 6 boys). A transient positive reaction was observed in 111 children. Clinical relevance of nickel sensitivity was found in only 1 child. No reproducible positive reaction to fragrance mix was found. The high proportion of transient patch test reactivity to nickel sulfate 200 microg/cm(2) indicates that this standard concentration used for adults cannot be applied to infants. The interpretation of a single positive nickel patch test in infants must be assessed with caution and it is probably of non-specific or irritant nature.",
keywords = "Allergens, Denmark, Dermatitis, Allergic Contact, Dose-Response Relationship, Drug, Female, Humans, Infant, Infant, Newborn, Irritants, Male, Nickel, Patch Tests, Perfume, Prevalence, Prospective Studies, Risk Assessment, Severity of Illness Index",
author = "H J{\o}hnke and Norberg, \{L A\} and W Vach and C Bindslev-Jensen and A H{\o}st and Andersen, \{Klaus Ejner\}",
year = "2004",
month = sep,
day = "1",
doi = "10.1111/j.0105-1873.2004.00425.x",
language = "English",
volume = "51",
pages = "141--7",
journal = "Contact Dermatitis",
issn = "0105-1873",
publisher = "Wiley",
number = "3",
}