Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes: A Danish Nationwide Cohort Study, 2004-2012

Anil Mor, Klara Berencsi, Jens S Nielsen, Jørgen Rungby, Søren Friborg, Ivan Brandslund, Jens S Christiansen, Allan Vaag, Henning Beck-Nielsen, Henrik T Sørensen, Reimar W Thomsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND:  The excess risk of antibiotic use and hospital-treated infections in patients with type 2 diabetes (T2D) compared with general population is poorly understood.

METHODS:  In a nationwide cohort of patients with incident T2D (n = 155 158) and an age-, gender-, and residence-matched comparison cohort (n = 774 017), we used Cox regression to compute rates and confounder-adjusted rate ratios (aRRs) of community-based antibiotic prescription redemption and hospital-treated infections during 2004-2012.

RESULTS:  The rates of community-based antibiotic prescriptions in the T2D and comparison cohorts were 364 vs 275 per 1000 person-years after a median follow-up of 1.1 years (aRR = 1.24; 95% confidence interval [CI], 1.23 to 1.25). The corresponding rates for hospital-treated infection were 58 vs 39 per 1000 person-years after a median follow-up of 2.8 years (aRR = 1.49; 95% CI, 1.47 to 1.52). The aRRs were increased particularly for urinary tract infections (UTIs, 1.41; 95% CI, 1.35 to 1.45), skin infections (1.50; 95% CI, 1.45 to 1.55), septicemia (1.60; 95% CI, 1.53 to 1.67), and tuberculosis (1.61; 95% CI, 1.25 to 2.06) and of community-based antibiotics prescribed for UTIs (1.31; 95% CI, 1.29 to 1.33), Staphylococcus aureus infections (1.32; 95% CI, 1.30 to 1.34), and mycobacterial infections (1.69; 95% CI, 1.36 to 2.09). The 1-year aRR declined from 1.89 (95% CI, 1.75 to 2.04) in 2004 to 1.59 (95% CI, 1.45 to 1.74) in 2011 for hospital-treated infection (trend P = .007) and from 1.31 (95% CI, 1.27 to 1.36) in 2004 to 1.26 (95% CI, 1.22 to 1.30) in 2011 for community-based antibiotic prescriptions (trend P = .006).

CONCLUSIONS:  Patients with T2D have rates of community-based antibiotic prescriptions and hospital-treated infections that are higher than for the general population.

OriginalsprogEngelsk
TidsskriftClinical Infectious Diseases
Vol/bind63
Udgave nummer4
Sider (fra-til)501-511
ISSN1058-4838
DOI
StatusUdgivet - 2016

Fingeraftryk

Type 2 Diabetes Mellitus
Prescriptions
Cohort Studies
Confidence Intervals
Population
Skin

Citer dette

Mor, Anil ; Berencsi, Klara ; Nielsen, Jens S ; Rungby, Jørgen ; Friborg, Søren ; Brandslund, Ivan ; Christiansen, Jens S ; Vaag, Allan ; Beck-Nielsen, Henning ; Sørensen, Henrik T ; Thomsen, Reimar W. / Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes : A Danish Nationwide Cohort Study, 2004-2012. I: Clinical Infectious Diseases. 2016 ; Bind 63, Nr. 4. s. 501-511.
@article{748a5e66408d4bf785cda847c3a0d8b7,
title = "Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes: A Danish Nationwide Cohort Study, 2004-2012",
abstract = "BACKGROUND:  The excess risk of antibiotic use and hospital-treated infections in patients with type 2 diabetes (T2D) compared with general population is poorly understood.METHODS:  In a nationwide cohort of patients with incident T2D (n = 155 158) and an age-, gender-, and residence-matched comparison cohort (n = 774 017), we used Cox regression to compute rates and confounder-adjusted rate ratios (aRRs) of community-based antibiotic prescription redemption and hospital-treated infections during 2004-2012.RESULTS:  The rates of community-based antibiotic prescriptions in the T2D and comparison cohorts were 364 vs 275 per 1000 person-years after a median follow-up of 1.1 years (aRR = 1.24; 95{\%} confidence interval [CI], 1.23 to 1.25). The corresponding rates for hospital-treated infection were 58 vs 39 per 1000 person-years after a median follow-up of 2.8 years (aRR = 1.49; 95{\%} CI, 1.47 to 1.52). The aRRs were increased particularly for urinary tract infections (UTIs, 1.41; 95{\%} CI, 1.35 to 1.45), skin infections (1.50; 95{\%} CI, 1.45 to 1.55), septicemia (1.60; 95{\%} CI, 1.53 to 1.67), and tuberculosis (1.61; 95{\%} CI, 1.25 to 2.06) and of community-based antibiotics prescribed for UTIs (1.31; 95{\%} CI, 1.29 to 1.33), Staphylococcus aureus infections (1.32; 95{\%} CI, 1.30 to 1.34), and mycobacterial infections (1.69; 95{\%} CI, 1.36 to 2.09). The 1-year aRR declined from 1.89 (95{\%} CI, 1.75 to 2.04) in 2004 to 1.59 (95{\%} CI, 1.45 to 1.74) in 2011 for hospital-treated infection (trend P = .007) and from 1.31 (95{\%} CI, 1.27 to 1.36) in 2004 to 1.26 (95{\%} CI, 1.22 to 1.30) in 2011 for community-based antibiotic prescriptions (trend P = .006).CONCLUSIONS:  Patients with T2D have rates of community-based antibiotic prescriptions and hospital-treated infections that are higher than for the general population.",
author = "Anil Mor and Klara Berencsi and Nielsen, {Jens S} and J{\o}rgen Rungby and S{\o}ren Friborg and Ivan Brandslund and Christiansen, {Jens S} and Allan Vaag and Henning Beck-Nielsen and S{\o}rensen, {Henrik T} and Thomsen, {Reimar W}",
note = "{\circledC} The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.",
year = "2016",
doi = "10.1093/cid/ciw345",
language = "English",
volume = "63",
pages = "501--511",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
publisher = "Heinemann",
number = "4",

}

Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes : A Danish Nationwide Cohort Study, 2004-2012. / Mor, Anil; Berencsi, Klara; Nielsen, Jens S; Rungby, Jørgen; Friborg, Søren; Brandslund, Ivan; Christiansen, Jens S; Vaag, Allan; Beck-Nielsen, Henning; Sørensen, Henrik T; Thomsen, Reimar W.

I: Clinical Infectious Diseases, Bind 63, Nr. 4, 2016, s. 501-511.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Rates of Community-based Antibiotic Prescriptions and Hospital-treated Infections in Individuals With and Without Type 2 Diabetes

T2 - A Danish Nationwide Cohort Study, 2004-2012

AU - Mor, Anil

AU - Berencsi, Klara

AU - Nielsen, Jens S

AU - Rungby, Jørgen

AU - Friborg, Søren

AU - Brandslund, Ivan

AU - Christiansen, Jens S

AU - Vaag, Allan

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik T

AU - Thomsen, Reimar W

N1 - © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

PY - 2016

Y1 - 2016

N2 - BACKGROUND:  The excess risk of antibiotic use and hospital-treated infections in patients with type 2 diabetes (T2D) compared with general population is poorly understood.METHODS:  In a nationwide cohort of patients with incident T2D (n = 155 158) and an age-, gender-, and residence-matched comparison cohort (n = 774 017), we used Cox regression to compute rates and confounder-adjusted rate ratios (aRRs) of community-based antibiotic prescription redemption and hospital-treated infections during 2004-2012.RESULTS:  The rates of community-based antibiotic prescriptions in the T2D and comparison cohorts were 364 vs 275 per 1000 person-years after a median follow-up of 1.1 years (aRR = 1.24; 95% confidence interval [CI], 1.23 to 1.25). The corresponding rates for hospital-treated infection were 58 vs 39 per 1000 person-years after a median follow-up of 2.8 years (aRR = 1.49; 95% CI, 1.47 to 1.52). The aRRs were increased particularly for urinary tract infections (UTIs, 1.41; 95% CI, 1.35 to 1.45), skin infections (1.50; 95% CI, 1.45 to 1.55), septicemia (1.60; 95% CI, 1.53 to 1.67), and tuberculosis (1.61; 95% CI, 1.25 to 2.06) and of community-based antibiotics prescribed for UTIs (1.31; 95% CI, 1.29 to 1.33), Staphylococcus aureus infections (1.32; 95% CI, 1.30 to 1.34), and mycobacterial infections (1.69; 95% CI, 1.36 to 2.09). The 1-year aRR declined from 1.89 (95% CI, 1.75 to 2.04) in 2004 to 1.59 (95% CI, 1.45 to 1.74) in 2011 for hospital-treated infection (trend P = .007) and from 1.31 (95% CI, 1.27 to 1.36) in 2004 to 1.26 (95% CI, 1.22 to 1.30) in 2011 for community-based antibiotic prescriptions (trend P = .006).CONCLUSIONS:  Patients with T2D have rates of community-based antibiotic prescriptions and hospital-treated infections that are higher than for the general population.

AB - BACKGROUND:  The excess risk of antibiotic use and hospital-treated infections in patients with type 2 diabetes (T2D) compared with general population is poorly understood.METHODS:  In a nationwide cohort of patients with incident T2D (n = 155 158) and an age-, gender-, and residence-matched comparison cohort (n = 774 017), we used Cox regression to compute rates and confounder-adjusted rate ratios (aRRs) of community-based antibiotic prescription redemption and hospital-treated infections during 2004-2012.RESULTS:  The rates of community-based antibiotic prescriptions in the T2D and comparison cohorts were 364 vs 275 per 1000 person-years after a median follow-up of 1.1 years (aRR = 1.24; 95% confidence interval [CI], 1.23 to 1.25). The corresponding rates for hospital-treated infection were 58 vs 39 per 1000 person-years after a median follow-up of 2.8 years (aRR = 1.49; 95% CI, 1.47 to 1.52). The aRRs were increased particularly for urinary tract infections (UTIs, 1.41; 95% CI, 1.35 to 1.45), skin infections (1.50; 95% CI, 1.45 to 1.55), septicemia (1.60; 95% CI, 1.53 to 1.67), and tuberculosis (1.61; 95% CI, 1.25 to 2.06) and of community-based antibiotics prescribed for UTIs (1.31; 95% CI, 1.29 to 1.33), Staphylococcus aureus infections (1.32; 95% CI, 1.30 to 1.34), and mycobacterial infections (1.69; 95% CI, 1.36 to 2.09). The 1-year aRR declined from 1.89 (95% CI, 1.75 to 2.04) in 2004 to 1.59 (95% CI, 1.45 to 1.74) in 2011 for hospital-treated infection (trend P = .007) and from 1.31 (95% CI, 1.27 to 1.36) in 2004 to 1.26 (95% CI, 1.22 to 1.30) in 2011 for community-based antibiotic prescriptions (trend P = .006).CONCLUSIONS:  Patients with T2D have rates of community-based antibiotic prescriptions and hospital-treated infections that are higher than for the general population.

U2 - 10.1093/cid/ciw345

DO - 10.1093/cid/ciw345

M3 - Journal article

C2 - 27353662

VL - 63

SP - 501

EP - 511

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

SN - 1058-4838

IS - 4

ER -