Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage

Mihaly Aradi, Edit Koszegi, Gergely Orsi, Gabor Perlaki, Anita Trauninger, Arnold Toth, Attila Schwarcz, Zsolt Illes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established.

METHODS: After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects.

RESULTS: Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in 'normal appearing white matter' (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls.

CONCLUSION: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.

OriginalsprogEngelsk
TidsskriftEuropean Neurology
Vol/bind69
Udgave nummer4
Sider (fra-til)221-225
ISSN0014-3022
DOI
StatusUdgivet - 2013

Fingeraftryk

Neuromyelitis Optica
Protons
White Matter

Citer dette

Aradi, Mihaly ; Koszegi, Edit ; Orsi, Gergely ; Perlaki, Gabor ; Trauninger, Anita ; Toth, Arnold ; Schwarcz, Attila ; Illes, Zsolt. / Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage. I: European Neurology. 2013 ; Bind 69, Nr. 4. s. 221-225.
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title = "Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage",
abstract = "BACKGROUND: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established.METHODS: After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects.RESULTS: Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in 'normal appearing white matter' (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls.CONCLUSION: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.",
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Aradi, M, Koszegi, E, Orsi, G, Perlaki, G, Trauninger, A, Toth, A, Schwarcz, A & Illes, Z 2013, 'Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage', European Neurology, bind 69, nr. 4, s. 221-225. https://doi.org/10.1159/000345799

Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage. / Aradi, Mihaly; Koszegi, Edit; Orsi, Gergely; Perlaki, Gabor; Trauninger, Anita; Toth, Arnold; Schwarcz, Attila; Illes, Zsolt.

I: European Neurology, Bind 69, Nr. 4, 2013, s. 221-225.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Quantitative MRI analysis of the brain after twenty-two years of neuromyelitis optica indicates focal tissue damage

AU - Aradi, Mihaly

AU - Koszegi, Edit

AU - Orsi, Gergely

AU - Perlaki, Gabor

AU - Trauninger, Anita

AU - Toth, Arnold

AU - Schwarcz, Attila

AU - Illes, Zsolt

N1 - Copyright © 2013 S. Karger AG, Basel.

PY - 2013

Y1 - 2013

N2 - BACKGROUND: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established.METHODS: After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects.RESULTS: Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in 'normal appearing white matter' (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls.CONCLUSION: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.

AB - BACKGROUND: The long-term effect of neuromyelitis optica (NMO) on the brain is not well established.METHODS: After 22 years of NMO, a patient's brain was examined by quantitative T1- and T2-weighted mono- and biexponential diffusion and proton spectroscopy. It was compared to 3 cases with short-term NMO and 20 healthy subjects.RESULTS: Although routine T1- and T2-weighted images appeared to be normal, quantitative T1-, T2- and diffusion-weighted magnetic resonance imaging identified areas with high diffusivity and altered relaxation time in 'normal appearing white matter' (NAWM). In such abnormal NAWM regions, biexponential diffusion analysis and quantitative spectroscopy indicated extracellular edema and axonal loss, respectively. Repeated analysis 6 months later identified the same alterations. Such patchy alterations were not detectable in the NAWM of the 3 cases with short-term NMO, and they were also not quantitatively different from the controls.CONCLUSION: After NMO of 22-year duration, metabolic changes, altered diffusivity and magnetic resonance relaxation features of patchy brain areas may suggest tissue damage in NAWM that persist for at least 6 months.

KW - Adult

KW - Brain

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Humans

KW - Longitudinal Studies

KW - Magnetic Resonance Imaging

KW - Neuromyelitis Optica

KW - Protons

KW - Spectrum Analysis

KW - Young Adult

U2 - 10.1159/000345799

DO - 10.1159/000345799

M3 - Journal article

C2 - 23344153

VL - 69

SP - 221

EP - 225

JO - European Neurology

JF - European Neurology

SN - 0014-3022

IS - 4

ER -