Quantitative linkage genome scan for atopy in a large collection of Caucasian families

Bradley T. Webb, Edwin Oord, Anthony Akkari, Steve Wilton, Tina Ly, Rachael Duff, Kathleen C. Barnes, Karin Carlsen, Jorrit Gerritsen, Warren Lenney, Michael Silverman, Peter Sly, John Sundy, John Tsanakas, Andrea Berg, Moira Whyte, Malcolm Blumenthal, Jorgen Vestbo, Lefkos Middleton, Peter J. Helms & 2 andre Wayne H. Anderson, Sreekumar G. Pillai

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD ≥ 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders. © Springer-Verlag 2006.
OriginalsprogEngelsk
TidsskriftHuman Genetics
Vol/bind121
Udgave nummer1
Sider (fra-til)83-92
Antal sider10
ISSN1432-1203
DOI
StatusUdgivet - mar. 2007
Udgivet eksterntJa

Fingeraftryk

Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 1
Sample Size
Serum

Citer dette

Webb, B. T., Oord, E., Akkari, A., Wilton, S., Ly, T., Duff, R., ... Pillai, S. G. (2007). Quantitative linkage genome scan for atopy in a large collection of Caucasian families. Human Genetics, 121(1), 83-92. https://doi.org/10.1007/s00439-006-0285-z
Webb, Bradley T. ; Oord, Edwin ; Akkari, Anthony ; Wilton, Steve ; Ly, Tina ; Duff, Rachael ; Barnes, Kathleen C. ; Carlsen, Karin ; Gerritsen, Jorrit ; Lenney, Warren ; Silverman, Michael ; Sly, Peter ; Sundy, John ; Tsanakas, John ; Berg, Andrea ; Whyte, Moira ; Blumenthal, Malcolm ; Vestbo, Jorgen ; Middleton, Lefkos ; Helms, Peter J. ; Anderson, Wayne H. ; Pillai, Sreekumar G. / Quantitative linkage genome scan for atopy in a large collection of Caucasian families. I: Human Genetics. 2007 ; Bind 121, Nr. 1. s. 83-92.
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title = "Quantitative linkage genome scan for atopy in a large collection of Caucasian families",
abstract = "Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD ≥ 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders. {\circledC} Springer-Verlag 2006.",
author = "Webb, {Bradley T.} and Edwin Oord and Anthony Akkari and Steve Wilton and Tina Ly and Rachael Duff and Barnes, {Kathleen C.} and Karin Carlsen and Jorrit Gerritsen and Warren Lenney and Michael Silverman and Peter Sly and John Sundy and John Tsanakas and Andrea Berg and Moira Whyte and Malcolm Blumenthal and Jorgen Vestbo and Lefkos Middleton and Helms, {Peter J.} and Anderson, {Wayne H.} and Pillai, {Sreekumar G.}",
year = "2007",
month = "3",
doi = "10.1007/s00439-006-0285-z",
language = "English",
volume = "121",
pages = "83--92",
journal = "Human Genetics",
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Webb, BT, Oord, E, Akkari, A, Wilton, S, Ly, T, Duff, R, Barnes, KC, Carlsen, K, Gerritsen, J, Lenney, W, Silverman, M, Sly, P, Sundy, J, Tsanakas, J, Berg, A, Whyte, M, Blumenthal, M, Vestbo, J, Middleton, L, Helms, PJ, Anderson, WH & Pillai, SG 2007, 'Quantitative linkage genome scan for atopy in a large collection of Caucasian families', Human Genetics, bind 121, nr. 1, s. 83-92. https://doi.org/10.1007/s00439-006-0285-z

Quantitative linkage genome scan for atopy in a large collection of Caucasian families. / Webb, Bradley T.; Oord, Edwin; Akkari, Anthony; Wilton, Steve; Ly, Tina; Duff, Rachael; Barnes, Kathleen C.; Carlsen, Karin; Gerritsen, Jorrit; Lenney, Warren; Silverman, Michael; Sly, Peter; Sundy, John; Tsanakas, John; Berg, Andrea; Whyte, Moira; Blumenthal, Malcolm; Vestbo, Jorgen; Middleton, Lefkos; Helms, Peter J.; Anderson, Wayne H.; Pillai, Sreekumar G.

I: Human Genetics, Bind 121, Nr. 1, 03.2007, s. 83-92.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Quantitative linkage genome scan for atopy in a large collection of Caucasian families

AU - Webb, Bradley T.

AU - Oord, Edwin

AU - Akkari, Anthony

AU - Wilton, Steve

AU - Ly, Tina

AU - Duff, Rachael

AU - Barnes, Kathleen C.

AU - Carlsen, Karin

AU - Gerritsen, Jorrit

AU - Lenney, Warren

AU - Silverman, Michael

AU - Sly, Peter

AU - Sundy, John

AU - Tsanakas, John

AU - Berg, Andrea

AU - Whyte, Moira

AU - Blumenthal, Malcolm

AU - Vestbo, Jorgen

AU - Middleton, Lefkos

AU - Helms, Peter J.

AU - Anderson, Wayne H.

AU - Pillai, Sreekumar G.

PY - 2007/3

Y1 - 2007/3

N2 - Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD ≥ 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders. © Springer-Verlag 2006.

AB - Quantitative phenotypes correlated with a complex disorder offer increased power to detect linkage in comparison to affected-unaffected classifications. Asthma is a complex disorder characterized by periods of bronchial obstruction and increased bronchial hyper reactivity. In childhood and early adulthood, asthma is frequently associated also with quantitative measures of atopy. Genome wide quantitative multipoint linkage analysis was conducted for serum IgE levels and percentage of positive skin prick test (SPTper) using three large groups of families originally ascertained for asthma. In this report, 438 and 429 asthma families were informative for linkage using IgE and SPTper which represents 690 independent families. Suggestive linkage (LOD ≥ 2) was found on chromosomes 1, 3, and 8q with maximum LODs of 2.34 (IgE), 2.03 (SPTper), and 2.25 (IgE) near markers D1S1653, D3S2322-D3S1764, and D8S2324, respectively. The results from chromosomes 1 and 3 replicate previous reports of linkage. We also replicate linkage to 5q with peak LODs of 1.96 (SPTper) and 1.77 (IgE) at or near marker D5S1480. Our results provide further evidence implicating chromosomes 1, 3, and 5q. The current report represents one of the biggest genome scans so far reported for asthma related phenotypes. This study also demonstrates the utility of increased sample sizes and quantitative phenotypes in linkage analysis of complex disorders. © Springer-Verlag 2006.

U2 - 10.1007/s00439-006-0285-z

DO - 10.1007/s00439-006-0285-z

M3 - Journal article

VL - 121

SP - 83

EP - 92

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 1

ER -