Quantiferon test for tuberculosis screening in sarcoidosis patients

Nils Milman, Bolette Søborg, Claus Bo Svendsen, Åse Bengård Andersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Infectious Diseases
Vol/bind43
Udgave nummer9
Sider (fra-til)728-35
Antal sider8
ISSN0036-5548
DOI
StatusUdgivet - 2011

Fingeraftryk

Latent Tuberculosis
Sarcoidosis
Interferon-gamma Release Tests
Tuberculin Test
Immunosuppressive Agents
Gold
Tumor Necrosis Factor-alpha

Citer dette

Milman, Nils ; Søborg, Bolette ; Svendsen, Claus Bo ; Bengård Andersen, Åse. / Quantiferon test for tuberculosis screening in sarcoidosis patients. I: Scandinavian Journal of Infectious Diseases. 2011 ; Bind 43, Nr. 9. s. 728-35.
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Quantiferon test for tuberculosis screening in sarcoidosis patients. / Milman, Nils; Søborg, Bolette; Svendsen, Claus Bo; Bengård Andersen, Åse.

I: Scandinavian Journal of Infectious Diseases, Bind 43, Nr. 9, 2011, s. 728-35.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Quantiferon test for tuberculosis screening in sarcoidosis patients

AU - Milman, Nils

AU - Søborg, Bolette

AU - Svendsen, Claus Bo

AU - Bengård Andersen, Åse

PY - 2011

Y1 - 2011

N2 - Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.

AB - Tumour necrosis factor-alpha (TNF-α) inhibitors have been introduced in the treatment of refractory sarcoidosis. These biologics may reactivate latent tuberculosis infection (LTBI). Despite its known limitations, the tuberculin skin test (TST) is currently used for the diagnosis of LTBI in Danish sarcoidosis patients. We report the results of a screening using the interferon-gamma release assay (IGRA) QuantiFERON TB Gold (QFN) for the diagnosis of LTBI. We aimed to assess whether the QFN is reliable for diagnosing LTBI among sarcoidosis patients and if results are influenced by disease activity or immunosuppressive treatment.

U2 - 10.3109/00365548.2011.582141

DO - 10.3109/00365548.2011.582141

M3 - Journal article

VL - 43

SP - 728

EP - 735

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 9

ER -