Quality of life in unaffected twins discordant for affective disorder

Maj Vinberg, Per Bech, Kirsten Ohm Kyvik, Lars Vedel Kessing

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Udgivelsesdato: Apr
OriginalsprogEngelsk
TidsskriftJournal of Affective Disorders
Vol/bind99
Udgave nummer1-3
Sider (fra-til)133-138
Antal sider5
ISSN0165-0327
DOI
StatusUdgivet - 2006

Fingeraftryk

Quality of Life
Dizygotic Twins
Monozygotic Twins
Marital Status
Case-Control Studies
Cross-Sectional Studies
Regression Analysis
Depression
Education
Control Groups
Health

Citer dette

Vinberg, Maj ; Bech, Per ; Kyvik, Kirsten Ohm ; Kessing, Lars Vedel. / Quality of life in unaffected twins discordant for affective disorder. I: Journal of Affective Disorders. 2006 ; Bind 99, Nr. 1-3. s. 133-138.
@article{07817f30e11d11db9628000ea68e967b,
title = "Quality of life in unaffected twins discordant for affective disorder",
abstract = "BACKGROUND: The disability and hardship associated with affective disorder is shared by the family members of affective patients and might affect the family member's quality of life. METHOD: In a cross-sectional, high-risk, case-control study, monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (the control group/Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. The aim of the present study was to investigate the hypothesis that a genetic liability to affective disorder is associated with a lower perception of quality of life. RESULTS: Univariate analyses showed that quality of life in all domains was impaired for the 121 High-Risk twins compared to the 84 Low-Risk twins. In multiple regression analyses, the differences remained significant after adjustment for sex, age, marital status and years of education. Adjusted for the effect of subclinical anxiety and depressive symptoms, the differences were significant on the domain environment and total WHOQoL-BREF and marginally significant on the domain physical health and overall quality of life. LIMITATIONS: It is not possible from the cross-sectional analyses to distinguish between subsyndromal state and trait scores. CONCLUSIONS: Perceived health related quality of life might share common familial vulnerability with affective disorders. Having a co-twin with affective disorder seem to have a negative influence on quality of life of the healthy co-twin and this influence might be due to the genetic liability to affective disorder. These findings need to be replicated in future family studies.",
keywords = "Adult, Anxiety Disorders, Cohort Studies, Cross-Sectional Studies, Denmark, Depressive Disorder, Diseases in Twins, Female, Follow-Up Studies, Genetic Predisposition to Disease, Humans, Male, Medical Record Linkage, Middle Aged, Mood Disorders, Multivariate Analysis, Quality of Life, Registries, Risk Factors, Twins, Dizygotic, Twins, Monozygotic",
author = "Maj Vinberg and Per Bech and Kyvik, {Kirsten Ohm} and Kessing, {Lars Vedel}",
year = "2006",
doi = "10.1016/j.jad.2006.08.033",
language = "English",
volume = "99",
pages = "133--138",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",
number = "1-3",

}

Quality of life in unaffected twins discordant for affective disorder. / Vinberg, Maj; Bech, Per; Kyvik, Kirsten Ohm; Kessing, Lars Vedel.

I: Journal of Affective Disorders, Bind 99, Nr. 1-3, 2006, s. 133-138.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Quality of life in unaffected twins discordant for affective disorder

AU - Vinberg, Maj

AU - Bech, Per

AU - Kyvik, Kirsten Ohm

AU - Kessing, Lars Vedel

PY - 2006

Y1 - 2006

N2 - BACKGROUND: The disability and hardship associated with affective disorder is shared by the family members of affective patients and might affect the family member's quality of life. METHOD: In a cross-sectional, high-risk, case-control study, monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (the control group/Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. The aim of the present study was to investigate the hypothesis that a genetic liability to affective disorder is associated with a lower perception of quality of life. RESULTS: Univariate analyses showed that quality of life in all domains was impaired for the 121 High-Risk twins compared to the 84 Low-Risk twins. In multiple regression analyses, the differences remained significant after adjustment for sex, age, marital status and years of education. Adjusted for the effect of subclinical anxiety and depressive symptoms, the differences were significant on the domain environment and total WHOQoL-BREF and marginally significant on the domain physical health and overall quality of life. LIMITATIONS: It is not possible from the cross-sectional analyses to distinguish between subsyndromal state and trait scores. CONCLUSIONS: Perceived health related quality of life might share common familial vulnerability with affective disorders. Having a co-twin with affective disorder seem to have a negative influence on quality of life of the healthy co-twin and this influence might be due to the genetic liability to affective disorder. These findings need to be replicated in future family studies.

AB - BACKGROUND: The disability and hardship associated with affective disorder is shared by the family members of affective patients and might affect the family member's quality of life. METHOD: In a cross-sectional, high-risk, case-control study, monozygotic (MZ) and dizygotic (DZ) twins with (High-Risk twins) and without (the control group/Low-Risk twins) a co-twin history of affective disorder were identified through nationwide registers. The aim of the present study was to investigate the hypothesis that a genetic liability to affective disorder is associated with a lower perception of quality of life. RESULTS: Univariate analyses showed that quality of life in all domains was impaired for the 121 High-Risk twins compared to the 84 Low-Risk twins. In multiple regression analyses, the differences remained significant after adjustment for sex, age, marital status and years of education. Adjusted for the effect of subclinical anxiety and depressive symptoms, the differences were significant on the domain environment and total WHOQoL-BREF and marginally significant on the domain physical health and overall quality of life. LIMITATIONS: It is not possible from the cross-sectional analyses to distinguish between subsyndromal state and trait scores. CONCLUSIONS: Perceived health related quality of life might share common familial vulnerability with affective disorders. Having a co-twin with affective disorder seem to have a negative influence on quality of life of the healthy co-twin and this influence might be due to the genetic liability to affective disorder. These findings need to be replicated in future family studies.

KW - Adult

KW - Anxiety Disorders

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Denmark

KW - Depressive Disorder

KW - Diseases in Twins

KW - Female

KW - Follow-Up Studies

KW - Genetic Predisposition to Disease

KW - Humans

KW - Male

KW - Medical Record Linkage

KW - Middle Aged

KW - Mood Disorders

KW - Multivariate Analysis

KW - Quality of Life

KW - Registries

KW - Risk Factors

KW - Twins, Dizygotic

KW - Twins, Monozygotic

U2 - 10.1016/j.jad.2006.08.033

DO - 10.1016/j.jad.2006.08.033

M3 - Journal article

C2 - 17023051

VL - 99

SP - 133

EP - 138

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 1-3

ER -