QT dynamics in risk stratification after myocardial infarction

Berit T Jensen, Steen Abildstrøm, Charlotte E Larroude, Erik Agner, Christian Torp-Pedersen, Ole Nyvad, Michael Ottesen, Kristian Wachtell, Jørgen K Kanters

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    Resumé

    Udgivelsesdato: 2005-Apr
    OriginalsprogEngelsk
    TidsskriftHeart Rhythm
    Vol/bind2
    Udgave nummer4
    Sider (fra-til)357-64
    Antal sider7
    ISSN1547-5271
    DOI
    StatusUdgivet - 1. apr. 2005

    Fingeraftryk

    Ventricular Premature Complexes
    Sudden Death
    Left Ventricular Function
    Proportional Hazards Models
    Cause of Death
    Multivariate Analysis

    Citer dette

    Jensen, B. T., Abildstrøm, S., Larroude, C. E., Agner, E., Torp-Pedersen, C., Nyvad, O., ... Kanters, J. K. (2005). QT dynamics in risk stratification after myocardial infarction. Heart Rhythm, 2(4), 357-64. https://doi.org/10.1016/j.hrthm.2004.12.028
    Jensen, Berit T ; Abildstrøm, Steen ; Larroude, Charlotte E ; Agner, Erik ; Torp-Pedersen, Christian ; Nyvad, Ole ; Ottesen, Michael ; Wachtell, Kristian ; Kanters, Jørgen K. / QT dynamics in risk stratification after myocardial infarction. I: Heart Rhythm. 2005 ; Bind 2, Nr. 4. s. 357-64.
    @article{ffd7c01081a511de9c46000ea68e967b,
    title = "QT dynamics in risk stratification after myocardial infarction",
    abstract = "OBJECTIVES: The purpose of this study was to compare measures of repolarization dynamics (QT dynamics) with other Holter risk predictors, left ventricular systolic function, and demographic characteristics to establish whether QT dynamics add independent information on risk stratification after myocardial infarction (MI). A novel QT dynamics parameter, the QT/RR variability ratio (VR), was introduced in this study. BACKGROUND: Abnormal repolarization contributes to arrhythmogenesis, and quantification of QT dynamics may have prognostic value after MI. METHODS: A 24-hour Holter recording was performed in 481 consecutive MI patients. Recordings from 311 patients were included in the analysis. QT/RR slope and intercept, mean and standard deviation of all QT, QTc, and RR intervals, and VR (defined as the ratio between the standard deviation of all QT intervals and the standard deviation of all RR interval) were calculated. Ventricular premature beats and ventricular tachycardia were counted. RESULTS: During 3-year follow-up, 70 deaths from all causes occurred. All parameters except mean of all QT intervals and standard deviation of all QTc intervals univariately predicted all-cause mortality. In multivariate Cox analysis, only VR per 0.1 (hazard ratio [HR]: 1.9 [1.5-2.4]), left ventricular ejection fraction per 5{\%} (HR: 1.2 [1.1-1.3]), ventricular premature beats per 10 beats/hour (HR: 1.03 [1.002-1.06]), and age per 10 years (HR: 1.6 [1.3-2.0]) independently predicted all-cause mortality. CONCLUSIONS: Measures of QT dynamics univariately predicted total mortality. VR, left ventricular ejection fraction, ventricular premature beats, and age made up the optimal Cox model for risk stratification after MI. VR seems to be a promising risk factor for identifying sudden arrhythmic death.",
    author = "Jensen, {Berit T} and Steen Abildstr{\o}m and Larroude, {Charlotte E} and Erik Agner and Christian Torp-Pedersen and Ole Nyvad and Michael Ottesen and Kristian Wachtell and Kanters, {J{\o}rgen K}",
    year = "2005",
    month = "4",
    day = "1",
    doi = "10.1016/j.hrthm.2004.12.028",
    language = "English",
    volume = "2",
    pages = "357--64",
    journal = "Heart Rhythm",
    issn = "1547-5271",
    publisher = "Elsevier",
    number = "4",

    }

    Jensen, BT, Abildstrøm, S, Larroude, CE, Agner, E, Torp-Pedersen, C, Nyvad, O, Ottesen, M, Wachtell, K & Kanters, JK 2005, 'QT dynamics in risk stratification after myocardial infarction', Heart Rhythm, bind 2, nr. 4, s. 357-64. https://doi.org/10.1016/j.hrthm.2004.12.028

    QT dynamics in risk stratification after myocardial infarction. / Jensen, Berit T; Abildstrøm, Steen; Larroude, Charlotte E; Agner, Erik; Torp-Pedersen, Christian; Nyvad, Ole; Ottesen, Michael; Wachtell, Kristian; Kanters, Jørgen K.

    I: Heart Rhythm, Bind 2, Nr. 4, 01.04.2005, s. 357-64.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    TY - JOUR

    T1 - QT dynamics in risk stratification after myocardial infarction

    AU - Jensen, Berit T

    AU - Abildstrøm, Steen

    AU - Larroude, Charlotte E

    AU - Agner, Erik

    AU - Torp-Pedersen, Christian

    AU - Nyvad, Ole

    AU - Ottesen, Michael

    AU - Wachtell, Kristian

    AU - Kanters, Jørgen K

    PY - 2005/4/1

    Y1 - 2005/4/1

    N2 - OBJECTIVES: The purpose of this study was to compare measures of repolarization dynamics (QT dynamics) with other Holter risk predictors, left ventricular systolic function, and demographic characteristics to establish whether QT dynamics add independent information on risk stratification after myocardial infarction (MI). A novel QT dynamics parameter, the QT/RR variability ratio (VR), was introduced in this study. BACKGROUND: Abnormal repolarization contributes to arrhythmogenesis, and quantification of QT dynamics may have prognostic value after MI. METHODS: A 24-hour Holter recording was performed in 481 consecutive MI patients. Recordings from 311 patients were included in the analysis. QT/RR slope and intercept, mean and standard deviation of all QT, QTc, and RR intervals, and VR (defined as the ratio between the standard deviation of all QT intervals and the standard deviation of all RR interval) were calculated. Ventricular premature beats and ventricular tachycardia were counted. RESULTS: During 3-year follow-up, 70 deaths from all causes occurred. All parameters except mean of all QT intervals and standard deviation of all QTc intervals univariately predicted all-cause mortality. In multivariate Cox analysis, only VR per 0.1 (hazard ratio [HR]: 1.9 [1.5-2.4]), left ventricular ejection fraction per 5% (HR: 1.2 [1.1-1.3]), ventricular premature beats per 10 beats/hour (HR: 1.03 [1.002-1.06]), and age per 10 years (HR: 1.6 [1.3-2.0]) independently predicted all-cause mortality. CONCLUSIONS: Measures of QT dynamics univariately predicted total mortality. VR, left ventricular ejection fraction, ventricular premature beats, and age made up the optimal Cox model for risk stratification after MI. VR seems to be a promising risk factor for identifying sudden arrhythmic death.

    AB - OBJECTIVES: The purpose of this study was to compare measures of repolarization dynamics (QT dynamics) with other Holter risk predictors, left ventricular systolic function, and demographic characteristics to establish whether QT dynamics add independent information on risk stratification after myocardial infarction (MI). A novel QT dynamics parameter, the QT/RR variability ratio (VR), was introduced in this study. BACKGROUND: Abnormal repolarization contributes to arrhythmogenesis, and quantification of QT dynamics may have prognostic value after MI. METHODS: A 24-hour Holter recording was performed in 481 consecutive MI patients. Recordings from 311 patients were included in the analysis. QT/RR slope and intercept, mean and standard deviation of all QT, QTc, and RR intervals, and VR (defined as the ratio between the standard deviation of all QT intervals and the standard deviation of all RR interval) were calculated. Ventricular premature beats and ventricular tachycardia were counted. RESULTS: During 3-year follow-up, 70 deaths from all causes occurred. All parameters except mean of all QT intervals and standard deviation of all QTc intervals univariately predicted all-cause mortality. In multivariate Cox analysis, only VR per 0.1 (hazard ratio [HR]: 1.9 [1.5-2.4]), left ventricular ejection fraction per 5% (HR: 1.2 [1.1-1.3]), ventricular premature beats per 10 beats/hour (HR: 1.03 [1.002-1.06]), and age per 10 years (HR: 1.6 [1.3-2.0]) independently predicted all-cause mortality. CONCLUSIONS: Measures of QT dynamics univariately predicted total mortality. VR, left ventricular ejection fraction, ventricular premature beats, and age made up the optimal Cox model for risk stratification after MI. VR seems to be a promising risk factor for identifying sudden arrhythmic death.

    U2 - 10.1016/j.hrthm.2004.12.028

    DO - 10.1016/j.hrthm.2004.12.028

    M3 - Journal article

    C2 - 15851335

    VL - 2

    SP - 357

    EP - 364

    JO - Heart Rhythm

    JF - Heart Rhythm

    SN - 1547-5271

    IS - 4

    ER -

    Jensen BT, Abildstrøm S, Larroude CE, Agner E, Torp-Pedersen C, Nyvad O et al. QT dynamics in risk stratification after myocardial infarction. Heart Rhythm. 2005 apr 1;2(4):357-64. https://doi.org/10.1016/j.hrthm.2004.12.028