Pustulosis palmoplantaris udløst af angiotensinkonverterende enzymhaemmere

Jesper Grau Eriksen, J J Christiansen, I Asmussen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

Angiotensin-converting enzyme (ACE) is identical to kinase II, which inactivates bradykinin. Inhibition of bradykinin degradation by ACE inhibitors alters the kinin-kallikrein arachidonic acid system leading to increased concentrations of inflammatory metabolites. It has previously been demonstrated that the arachidonic acid system may play a role in the pathogenesis of psoriasis/volar pustulosis. Our patient was treated with Captopril and developed a rash identical to volar pustulosis within six weeks. Captopril was substituted with Perindopril, and the eruptions had almost disappeared five months later after a short systemic treatment with steroids. One month later the patient developed the same rash. Perindopril was withdrawn and the eruptions had disappeared two months later.

Bidragets oversatte titelPostulosis palmoplantaris caused by angiotensin-converting enzyme inhibitors
OriginalsprogDansk
TidsskriftUgeskrift for Laeger
Vol/bind157
Udgave nummer23
Sider (fra-til)3335-6
Antal sider2
ISSN0041-5782
StatusUdgivet - 5. jun. 1995

Emneord

  • Aged
  • Angiotensin-Converting Enzyme Inhibitors
  • Captopril
  • Female
  • Humans
  • Indoles
  • Kallikrein-Kinin System
  • Perindopril
  • Psoriasis

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