Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke

Publikation: Bidrag til tidsskriftReviewForskningpeer review

Resumé

Introduction: Inflammation is integral in the neuropathology of both chronic and acute neurological disorders. Knowing the inflammatory profile is important for clarification of disease mechanisms, diagnostic purposes, and ultimately treatment options. Areas covered: A systematic review was performed on literature from PubMed using the search terms 'Alzheimer's disease' (AD) or "multiple sclerosis" (MS) or "ischemic stroke" and 'proteomics'. Inflammatory proteins were assessed in blood, cerebrospinal fluid (CSF), and post-mortem brain tissue. Regulated inflammatory proteins across compartments and disorders mainly consisted of innate immune proteins, acute phase proteins and oxidative stress response proteins. In addition, immunoglobulin chains were signature proteins of MS, reflecting additional involvement of adaptive immunity. The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases. Furthermore, CNS/CSF AD inflammatory proteins were matched to a CNS myeloid cell proteome implicating Alpha-2-Macroglobulin and Annexin A1 in AD pathogenesis. Expert opinion: Proteomics is an excellent technique for profiling inflammatory proteins in tissues and cells, but still targeted approaches are required for profiling of very low abundance proteins and peptides. Knowing the inflammatory signature of brain tissue, CSF, blood, and CNS myeloid cells holds the potential to point to novel mechanistic aspects of neurological diseases.

OriginalsprogEngelsk
TidsskriftExpert Review of Proteomics
Vol/bind16
Udgave nummer7
Sider (fra-til)601-611
ISSN1478-9450
DOI
StatusUdgivet - jul. 2019

Fingeraftryk

Alzheimer Disease
Cerebrospinal fluid
Proteins
Cerebrospinal Fluid
Myeloid Cells
Tissue
Brain
Annexin A1
Blood
Immunoglobulin Subunits
alpha-Macroglobulins
Chitinases
Expert Testimony
Proteome
Oxidative stress
Heat-Shock Proteins
Proteomics
Acute-Phase Proteins
Nervous System Diseases
PubMed

Citer dette

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title = "Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke",
abstract = "Introduction: Inflammation is integral in the neuropathology of both chronic and acute neurological disorders. Knowing the inflammatory profile is important for clarification of disease mechanisms, diagnostic purposes, and ultimately treatment options. Areas covered: A systematic review was performed on literature from PubMed using the search terms 'Alzheimer's disease' (AD) or {"}multiple sclerosis{"} (MS) or {"}ischemic stroke{"} and 'proteomics'. Inflammatory proteins were assessed in blood, cerebrospinal fluid (CSF), and post-mortem brain tissue. Regulated inflammatory proteins across compartments and disorders mainly consisted of innate immune proteins, acute phase proteins and oxidative stress response proteins. In addition, immunoglobulin chains were signature proteins of MS, reflecting additional involvement of adaptive immunity. The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases. Furthermore, CNS/CSF AD inflammatory proteins were matched to a CNS myeloid cell proteome implicating Alpha-2-Macroglobulin and Annexin A1 in AD pathogenesis. Expert opinion: Proteomics is an excellent technique for profiling inflammatory proteins in tissues and cells, but still targeted approaches are required for profiling of very low abundance proteins and peptides. Knowing the inflammatory signature of brain tissue, CSF, blood, and CNS myeloid cells holds the potential to point to novel mechanistic aspects of neurological diseases.",
keywords = "Alzheimer’s disease, CNS myeloid cells, complement system, immunoglobulin, innate immunity, ischemic stroke, mass spectrometry-based proteomics, microglia, multiple sclerosis, neuroinflammation",
author = "Camilla Thygesen and Larsen, {Martin R{\"o}ssel} and Bente Finsen",
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Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke. / Thygesen, Camilla; Larsen, Martin Rössel; Finsen, Bente.

I: Expert Review of Proteomics, Bind 16, Nr. 7, 07.2019, s. 601-611.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - Proteomic signatures of neuroinflammation in Alzheimer's disease, multiple sclerosis and ischemic stroke

AU - Thygesen, Camilla

AU - Larsen, Martin Rössel

AU - Finsen, Bente

PY - 2019/7

Y1 - 2019/7

N2 - Introduction: Inflammation is integral in the neuropathology of both chronic and acute neurological disorders. Knowing the inflammatory profile is important for clarification of disease mechanisms, diagnostic purposes, and ultimately treatment options. Areas covered: A systematic review was performed on literature from PubMed using the search terms 'Alzheimer's disease' (AD) or "multiple sclerosis" (MS) or "ischemic stroke" and 'proteomics'. Inflammatory proteins were assessed in blood, cerebrospinal fluid (CSF), and post-mortem brain tissue. Regulated inflammatory proteins across compartments and disorders mainly consisted of innate immune proteins, acute phase proteins and oxidative stress response proteins. In addition, immunoglobulin chains were signature proteins of MS, reflecting additional involvement of adaptive immunity. The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases. Furthermore, CNS/CSF AD inflammatory proteins were matched to a CNS myeloid cell proteome implicating Alpha-2-Macroglobulin and Annexin A1 in AD pathogenesis. Expert opinion: Proteomics is an excellent technique for profiling inflammatory proteins in tissues and cells, but still targeted approaches are required for profiling of very low abundance proteins and peptides. Knowing the inflammatory signature of brain tissue, CSF, blood, and CNS myeloid cells holds the potential to point to novel mechanistic aspects of neurological diseases.

AB - Introduction: Inflammation is integral in the neuropathology of both chronic and acute neurological disorders. Knowing the inflammatory profile is important for clarification of disease mechanisms, diagnostic purposes, and ultimately treatment options. Areas covered: A systematic review was performed on literature from PubMed using the search terms 'Alzheimer's disease' (AD) or "multiple sclerosis" (MS) or "ischemic stroke" and 'proteomics'. Inflammatory proteins were assessed in blood, cerebrospinal fluid (CSF), and post-mortem brain tissue. Regulated inflammatory proteins across compartments and disorders mainly consisted of innate immune proteins, acute phase proteins and oxidative stress response proteins. In addition, immunoglobulin chains were signature proteins of MS, reflecting additional involvement of adaptive immunity. The Chitinase 3-like protein 1 was increased in ten original articles on MS and in three on AD supporting its implication in these diseases. Furthermore, CNS/CSF AD inflammatory proteins were matched to a CNS myeloid cell proteome implicating Alpha-2-Macroglobulin and Annexin A1 in AD pathogenesis. Expert opinion: Proteomics is an excellent technique for profiling inflammatory proteins in tissues and cells, but still targeted approaches are required for profiling of very low abundance proteins and peptides. Knowing the inflammatory signature of brain tissue, CSF, blood, and CNS myeloid cells holds the potential to point to novel mechanistic aspects of neurological diseases.

KW - Alzheimer’s disease

KW - CNS myeloid cells

KW - complement system

KW - immunoglobulin

KW - innate immunity

KW - ischemic stroke

KW - mass spectrometry-based proteomics

KW - microglia

KW - multiple sclerosis

KW - neuroinflammation

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DO - 10.1080/14789450.2019.1633919

M3 - Review

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JO - Expert Review of Proteomics

JF - Expert Review of Proteomics

SN - 1478-9450

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