Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

Medicin og biovidenskab

• Noonan Syndrome 100%
• Protein Tyrosine Phosphatases 84%
• src Homology Domains 82%
• Point Mutation 66%
• Leukemia 56%
• Mutation 38%
• LEOPARD Syndrome 29%
• Peptide Receptors 21%
• Proteins 18%
• Integrins 16%
• Mass Spectrometry 15%
• Intercellular Signaling Peptides and Proteins 13%
• Cell Differentiation 13%
• Cell Survival 13%
• Cell Proliferation 11%
• Cytokines 10%
• In Vitro Techniques 7%

Kemiske forbindelser

• Tyrosine 62%
• Protein 28%
• Growth Factor 20%
• Cell Viability 16%
• Enzyme Activity 14%
• Mass Spectrometry 11%