Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood-flow restriction

Jakob Lindberg Nielsen, Per Aagaard, Rune Dueholm Bech, Tobias Nygaard, Lars Grøndahl Hvid, Mathias Wernbom, Charlotte Arneboe Suetta, Ulrik Frandsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Low-load resistance training with blood-flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however the effect on myogenic stem cells (MSC) and myonuclei number remains unexplored. Ten male subjects (22.8±2.3 yrs) performed 4 sets of knee extensor exercise (20% 1RM) to concentric failure during blood-flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9±3.0 yrs) trained without BFR (CON). 23 training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre and post training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P
OriginalsprogEngelsk
TidsskriftJournal of Physiology
Vol/bind590
Udgave nummer17
Sider (fra-til)4351-4361
ISSN0022-3751
DOI
StatusUdgivet - 2012

Fingeraftryk

Resistance Training
Skeletal Muscle
Knee
Muscles

Bibliografisk note

Published online before print July 16 2012

Citer dette

Nielsen, Jakob Lindberg ; Aagaard, Per ; Bech, Rune Dueholm ; Nygaard, Tobias ; Hvid, Lars Grøndahl ; Wernbom, Mathias ; Suetta, Charlotte Arneboe ; Frandsen, Ulrik. / Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood-flow restriction. I: Journal of Physiology. 2012 ; Bind 590, Nr. 17. s. 4351-4361.
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abstract = "Low-load resistance training with blood-flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however the effect on myogenic stem cells (MSC) and myonuclei number remains unexplored. Ten male subjects (22.8±2.3 yrs) performed 4 sets of knee extensor exercise (20{\%} 1RM) to concentric failure during blood-flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9±3.0 yrs) trained without BFR (CON). 23 training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre and post training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1{\%} (Post5) and 10.6{\%} (Post12) (P",
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Proliferation of myogenic stem cells in human skeletal muscle in response to low-load resistance training with blood-flow restriction. / Nielsen, Jakob Lindberg; Aagaard, Per; Bech, Rune Dueholm; Nygaard, Tobias; Hvid, Lars Grøndahl; Wernbom, Mathias; Suetta, Charlotte Arneboe; Frandsen, Ulrik.

I: Journal of Physiology, Bind 590, Nr. 17, 2012, s. 4351-4361.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

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AU - Nielsen, Jakob Lindberg

AU - Aagaard, Per

AU - Bech, Rune Dueholm

AU - Nygaard, Tobias

AU - Hvid, Lars Grøndahl

AU - Wernbom, Mathias

AU - Suetta, Charlotte Arneboe

AU - Frandsen, Ulrik

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PY - 2012

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AB - Low-load resistance training with blood-flow restriction has been shown to elicit substantial increases in muscle mass and muscle strength; however the effect on myogenic stem cells (MSC) and myonuclei number remains unexplored. Ten male subjects (22.8±2.3 yrs) performed 4 sets of knee extensor exercise (20% 1RM) to concentric failure during blood-flow restriction (BFR) of the proximal thigh (100 mmHg), while eight work-matched controls (21.9±3.0 yrs) trained without BFR (CON). 23 training sessions were performed within 19 days. Maximal isometric knee extensor strength (MVC) was examined pre and post training, while muscle biopsies were obtained at baseline (Pre), after 8 days intervention (Mid8) and 3 (Post3) and 10 days (Post10) post training to examine changes in myofibre area (MFA), MSC and myonuclei number. MVC increased by 7.1% (Post5) and 10.6% (Post12) (P

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