Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron

Helge Thisgaard, M Jensen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron. With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.
OriginalsprogEngelsk
TidsskriftApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Vol/bind67
Udgave nummer1
Sider (fra-til)34-8
Antal sider5
DOI
StatusUdgivet - 1. jan. 2009
Udgivet eksterntJa

Fingeraftryk

Cyclotrons
Radioisotopes
radioactive isotopes
cyclotrons
Tumors
therapy
emitters
Radioactivity
tumors
cancer
Isotopes
Neoplasms
Cells
radioactivity
Neoplasm Micrometastasis
Electrons
purity
isotopes
electrons
energy

Citer dette

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title = "Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron",
abstract = "The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron. With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.",
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T1 - Production of the Auger emitter 119Sb for targeted radionuclide therapy using a small PET-cyclotron

AU - Thisgaard, Helge

AU - Jensen, M

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N2 - The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron. With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.

AB - The use of Auger electrons in radionuclide therapy of cancer is a promising tool for specific tumor cell killing of micrometastases and small tumors. The radioisotope (119)Sb has recently been identified as a potent Auger-emitter for therapy. We here present a method for producing this isotope using a low-energy cyclotron. With this method, it will be possible to produce clinically relevant amounts of (119)Sb radioactivity with high chemical and radionuclidic purity for cancer therapy.

U2 - 10.1016/j.apradiso.2008.09.003

DO - 10.1016/j.apradiso.2008.09.003

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JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

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