Primary localized amyloidosis of the eyelid

two cases of immunoglobulin light chain-derived proteins, subtype lambda V respectively lambda VI

K E Olsen, O Sandgren, K Sletten, Per Westermark

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Primary localized amyloidosis has been described in many different organs in the body. Studies by immunohistochemical techniques have suggested an immunoglobulin light chain origin of the amyloid material. Only in a limited number of cases has the amyloid protein been characterized by amino acid sequence analysis as subtypes of immunoglobulin light chain or heavy chain. In this report, two cases of primary localized amyloidosis of the eyelid are presented. The amyloid substance has been extracted and a major fibril protein subjected to amino acid sequence analysis. Both amyloid proteins were part of the variable region of immunoglobulin light chains, subtype lambda V and subtype lambda VI, respectively. While lambda VI has been shown to be a common subtype in systemic immunoglobulin light chain-amyloidosis, it has never been demonstrated in localized amyloid. Very few lambda V immunoglobulin light chains have been characterized and the subgroup has never been found in amyloid before.

OriginalsprogEngelsk
TidsskriftClinical and Experimental Immunology
Vol/bind106
Udgave nummer2
Sider (fra-til)362-6
Antal sider5
ISSN0009-9104
StatusUdgivet - nov. 1996

Fingeraftryk

Eyelids
Immunoglobulin lambda-Chains
Protein Sequence Analysis
Proteins
Primary amyloidosis

Citer dette

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title = "Primary localized amyloidosis of the eyelid: two cases of immunoglobulin light chain-derived proteins, subtype lambda V respectively lambda VI",
abstract = "Primary localized amyloidosis has been described in many different organs in the body. Studies by immunohistochemical techniques have suggested an immunoglobulin light chain origin of the amyloid material. Only in a limited number of cases has the amyloid protein been characterized by amino acid sequence analysis as subtypes of immunoglobulin light chain or heavy chain. In this report, two cases of primary localized amyloidosis of the eyelid are presented. The amyloid substance has been extracted and a major fibril protein subjected to amino acid sequence analysis. Both amyloid proteins were part of the variable region of immunoglobulin light chains, subtype lambda V and subtype lambda VI, respectively. While lambda VI has been shown to be a common subtype in systemic immunoglobulin light chain-amyloidosis, it has never been demonstrated in localized amyloid. Very few lambda V immunoglobulin light chains have been characterized and the subgroup has never been found in amyloid before.",
keywords = "Aged, Amino Acid Sequence, Amyloid, Amyloidosis, Electrophoresis, Polyacrylamide Gel, Eyelid Diseases, Eyelids, Female, Humans, Immunoglobulin Variable Region, Immunoglobulin lambda-Chains, Middle Aged, Molecular Sequence Data, Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review",
author = "Olsen, {K E} and O Sandgren and K Sletten and Per Westermark",
year = "1996",
month = "11",
language = "English",
volume = "106",
pages = "362--6",
journal = "Clinical and Experimental Immunology",
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Primary localized amyloidosis of the eyelid : two cases of immunoglobulin light chain-derived proteins, subtype lambda V respectively lambda VI. / Olsen, K E; Sandgren, O; Sletten, K; Westermark, Per.

I: Clinical and Experimental Immunology, Bind 106, Nr. 2, 11.1996, s. 362-6.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Primary localized amyloidosis of the eyelid

T2 - two cases of immunoglobulin light chain-derived proteins, subtype lambda V respectively lambda VI

AU - Olsen, K E

AU - Sandgren, O

AU - Sletten, K

AU - Westermark, Per

PY - 1996/11

Y1 - 1996/11

N2 - Primary localized amyloidosis has been described in many different organs in the body. Studies by immunohistochemical techniques have suggested an immunoglobulin light chain origin of the amyloid material. Only in a limited number of cases has the amyloid protein been characterized by amino acid sequence analysis as subtypes of immunoglobulin light chain or heavy chain. In this report, two cases of primary localized amyloidosis of the eyelid are presented. The amyloid substance has been extracted and a major fibril protein subjected to amino acid sequence analysis. Both amyloid proteins were part of the variable region of immunoglobulin light chains, subtype lambda V and subtype lambda VI, respectively. While lambda VI has been shown to be a common subtype in systemic immunoglobulin light chain-amyloidosis, it has never been demonstrated in localized amyloid. Very few lambda V immunoglobulin light chains have been characterized and the subgroup has never been found in amyloid before.

AB - Primary localized amyloidosis has been described in many different organs in the body. Studies by immunohistochemical techniques have suggested an immunoglobulin light chain origin of the amyloid material. Only in a limited number of cases has the amyloid protein been characterized by amino acid sequence analysis as subtypes of immunoglobulin light chain or heavy chain. In this report, two cases of primary localized amyloidosis of the eyelid are presented. The amyloid substance has been extracted and a major fibril protein subjected to amino acid sequence analysis. Both amyloid proteins were part of the variable region of immunoglobulin light chains, subtype lambda V and subtype lambda VI, respectively. While lambda VI has been shown to be a common subtype in systemic immunoglobulin light chain-amyloidosis, it has never been demonstrated in localized amyloid. Very few lambda V immunoglobulin light chains have been characterized and the subgroup has never been found in amyloid before.

KW - Aged

KW - Amino Acid Sequence

KW - Amyloid

KW - Amyloidosis

KW - Electrophoresis, Polyacrylamide Gel

KW - Eyelid Diseases

KW - Eyelids

KW - Female

KW - Humans

KW - Immunoglobulin Variable Region

KW - Immunoglobulin lambda-Chains

KW - Middle Aged

KW - Molecular Sequence Data

KW - Case Reports

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

M3 - Journal article

VL - 106

SP - 362

EP - 366

JO - Clinical and Experimental Immunology

JF - Clinical and Experimental Immunology

SN - 0009-9104

IS - 2

ER -