Aims: To investigate the prevalence of urinary incontinence (UI) and UI subtypes (stress, urgency, and mixed UI) in women with or without diabetes mellitus; and to investigate the association between diabetes and UI (any and subtypes). Methods: A cross-sectional study based on the Lolland-Falster, Denmark population-based health study. From 2016 to 2020, clinical measurement, questionnaires, and blood tests were collected. A total of 8563 women aged 18 or older were enrolled. Data analysis included 7906 women. UI was defined as any involuntary leakage of urine during the previous 4 weeks. Multiple logistic regression was used to adjust for confounders: age, body mass index, parity, physical activity, previous gestational diabetes, education, and smoking. Results: UI prevalence was 50.3% in women with diabetes and 39.3% in women without diabetes. The unadjusted and adjusted odds ratio (OR) for UI in women with diabetes was OR 1.56 (95% confidence interval [CI], 1.27–1.92) and 1.11 (95% CI, 0.88–1.38), respectively. Mixed UI was associated with diabetes after controlling for confounders. A subgroup analysis found women using multiple antidiabetic medications had increased odds of UI, 2.75 (95% CI, 1.38–5.48), after controlling for confounders. Conclusion: The prevalence of UI in women with diabetes was higher than in women without diabetes. The odds of UI was 56% higher in women with diabetes compared with women without diabetes but the effect was attenuated when controlling for confounders and statistically significance was not achieved. For a subgroup using multiple antidiabetic medications, the risk of UI was higher than in women without diabetes.
Bibliografisk noteFunding Information:
The Lolland‐Falster Health Study (LOFUS), Nykøbing Falster Hospital, Denmark, is a collaboration between Region Zealand, Nykøbing Falster Hospital and Lolland and Guldborgsund Municipalities. The authors are grateful to LOFUS for making the LOFUS research data available. However, LOFUS bears no responsibility for the analysis or the interpretation conducted within this study. This study was funded by Nykøbing Falster Hospital; Department of Gynecology and Obstetrics, Nykøbing Falster Hospital; Region Zealand Health Research Fund; Department of Gynecology and Obstetrics, Zealand University Hospital, Roskilde; Production, Research, and Innovation, Region Zealand; “Cutting the Edge” prize from Astellas by cosupervisor Lea Laird Andersen; Edith and Henrik Henriksens memorial Fund; King Christian X's memorial Fund; Grosserer L.F. Foghts Fund; Aase and Ejnar Danielsen Fund; and AP Møller Fund.
© 2021 Wiley Periodicals LLC
Copyright 2021 Elsevier B.V., All rights reserved.