Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics

A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

Anne Gedebjerg*, Thomas Peter Almdal, Klara Berencsi, Jørgen Rungby, Jens Steen Nielsen, Daniel R. Witte, Søren Friborg, Ivan Brandslund, Allan Vaag, Henning Beck-Nielsen, Henrik Toft Sørensen, Reimar Wernich Thomsen

*Kontaktforfatter for dette arbejde

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Resumé

AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.

METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.

RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.

CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

OriginalsprogEngelsk
TidsskriftJournal of Diabetes and its Complications
Vol/bind32
Udgave nummer1
Sider (fra-til)34-40
ISSN1056-8727
DOI
StatusUdgivet - jan. 2018

Fingeraftryk

Diabetes Complications
Type 2 Diabetes Mellitus
Cross-Sectional Studies
Confidence Intervals
Hypertriglyceridemia
HDL Cholesterol
Smoking
Lipids
Research

Citer dette

Gedebjerg, Anne ; Almdal, Thomas Peter ; Berencsi, Klara ; Rungby, Jørgen ; Nielsen, Jens Steen ; Witte, Daniel R. ; Friborg, Søren ; Brandslund, Ivan ; Vaag, Allan ; Beck-Nielsen, Henning ; Sørensen, Henrik Toft ; Thomsen, Reimar Wernich. / Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics : A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. I: Journal of Diabetes and its Complications. 2018 ; Bind 32, Nr. 1. s. 34-40.
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title = "Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics: A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort",
abstract = "AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35{\%} (n=2456) T2D patients had diabetic complications around diagnosis; 12{\%} (n=828) had microvascular complications, 17{\%} (n=1186) macrovascular complications, and 6{\%} (n=442) had both. HbA1c levels of ≥7{\%} were associated with microvascular complications [HbA1c 7{\%}-8{\%}; aPR: 1.35, 95{\%} confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95{\%} CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95{\%} CI: 1.00-1.80] but not microvascular [aPR 0.97, 95{\%} CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.",
keywords = "Epidemiology, Macrovascular complications, Microvascular complications, Risk factors, Type 2 diabetes, Prevalence, Cross-Sectional Studies, Diabetes Complications/epidemiology, Humans, Middle Aged, Male, Diabetes Mellitus, Type 2/complications, Denmark/epidemiology, Time Factors, Aged, 80 and over, Delayed Diagnosis/statistics & numerical data, Adult, Female, Aged, Diabetic Angiopathies/classification, Cohort Studies",
author = "Anne Gedebjerg and Almdal, {Thomas Peter} and Klara Berencsi and J{\o}rgen Rungby and Nielsen, {Jens Steen} and Witte, {Daniel R.} and S{\o}ren Friborg and Ivan Brandslund and Allan Vaag and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft} and Thomsen, {Reimar Wernich}",
note = "Copyright {\circledC} 2017 Elsevier Inc. All rights reserved.",
year = "2018",
month = "1",
doi = "10.1016/j.jdiacomp.2017.09.010",
language = "English",
volume = "32",
pages = "34--40",
journal = "Journal of Diabetes and its Complications",
issn = "1056-8727",
publisher = "Elsevier",
number = "1",

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Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics : A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort. / Gedebjerg, Anne; Almdal, Thomas Peter; Berencsi, Klara; Rungby, Jørgen; Nielsen, Jens Steen; Witte, Daniel R.; Friborg, Søren; Brandslund, Ivan; Vaag, Allan; Beck-Nielsen, Henning; Sørensen, Henrik Toft; Thomsen, Reimar Wernich.

I: Journal of Diabetes and its Complications, Bind 32, Nr. 1, 01.2018, s. 34-40.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Prevalence of micro- and macrovascular diabetes complications at time of type 2 diabetes diagnosis and associated clinical characteristics

T2 - A cross-sectional baseline study of 6958 patients in the Danish DD2 cohort

AU - Gedebjerg, Anne

AU - Almdal, Thomas Peter

AU - Berencsi, Klara

AU - Rungby, Jørgen

AU - Nielsen, Jens Steen

AU - Witte, Daniel R.

AU - Friborg, Søren

AU - Brandslund, Ivan

AU - Vaag, Allan

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

AU - Thomsen, Reimar Wernich

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/1

Y1 - 2018/1

N2 - AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

AB - AIMS: To examine the prevalence of micro- and macrovascular complications and their associated clinical characteristics at time of type 2 diabetes (T2D) diagnosis.METHODS: We examined the prevalence of complications and associated clinical characteristics among 6958 newly diagnosed T2D patients enrolled in the prospective Danish Center for Strategic Research in T2D cohort during 2010-2016. We calculated age- and gender-adjusted prevalence ratios (aPRs) of complications using log-binomial and Poisson regression.RESULTS: In total, 35% (n=2456) T2D patients had diabetic complications around diagnosis; 12% (n=828) had microvascular complications, 17% (n=1186) macrovascular complications, and 6% (n=442) had both. HbA1c levels of ≥7% were associated with microvascular complications [HbA1c 7%-8%; aPR: 1.35, 95% confidence interval (CI): 1.12-1.62] but not macrovascular complications [aPR: 0.91, 95% CI: 0.76-1.08]. High C-peptide≥800pmol/L was associated with macrovascular [aPR 1.34, 95% CI: 1.00-1.80] but not microvascular [aPR 0.97, 95% CI: 0.71-1.33] complications. Macrovascular complications were associated with male sex, age>50years, obesity, hypertriglyceridemia, low HDL cholesterol, smoking, elevated CRP levels, and anti-hypertensive therapy. Microvascular complications were associated with high blood pressure, hypertriglyceridemia, and absence of lipid-lowering therapy.CONCLUSIONS: One-third of patients with T2D had diabetes complications around time of diagnosis. Our findings suggest different pathophysiological mechanisms behind micro- and macrovascular complications.

KW - Epidemiology

KW - Macrovascular complications

KW - Microvascular complications

KW - Risk factors

KW - Type 2 diabetes

KW - Prevalence

KW - Cross-Sectional Studies

KW - Diabetes Complications/epidemiology

KW - Humans

KW - Middle Aged

KW - Male

KW - Diabetes Mellitus, Type 2/complications

KW - Denmark/epidemiology

KW - Time Factors

KW - Aged, 80 and over

KW - Delayed Diagnosis/statistics & numerical data

KW - Adult

KW - Female

KW - Aged

KW - Diabetic Angiopathies/classification

KW - Cohort Studies

U2 - 10.1016/j.jdiacomp.2017.09.010

DO - 10.1016/j.jdiacomp.2017.09.010

M3 - Journal article

VL - 32

SP - 34

EP - 40

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 1

ER -