TY - JOUR
T1 - Prevalence of hyperthyroidism and hypothyroidism in liver transplant recipients and associated risk factors
AU - Suarez-Zdunek, Moises Alberto
AU - Arentoft, Nicoline Stender
AU - Krohn, Paul Suno
AU - Lauridsen, Emilie Høegholm Ernst
AU - Afzal, Shoaib
AU - Høgh, Julie
AU - Thomsen, Magda Teresa
AU - Knudsen, Andreas Dehlbæk
AU - Nordestgaard, Børge Grønne
AU - Hillingsø, Jens Georg
AU - Villadsen, Gerda Elisabeth
AU - Holland-Fischer, Peter
AU - Rasmussen, Allan
AU - Fialla, Anette Dam
AU - Feldt-Rasmussen, Ulla
AU - Nielsen, Susanne D.
PY - 2024/4/3
Y1 - 2024/4/3
N2 - The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).
AB - The prevalence of hyperthyroidism and hypothyroidism and associated risk factors are unknown in liver transplant recipients. We aimed to determine the prevalence of hyperthyroidism and hypothyroidism and associated risk factors in liver transplant recipients and to compare it with controls from the general population. As part of the Danish Comorbidity in Liver Transplant Recipients (DACOLT) Study, all Danish liver transplant recipients over the age of 20 were invited for measurements of concentrations of thyrotropin and thyroid hormones. The prevalence of hyperthyroidism and hypothyroidism was compared to age- and sex-matched controls from the Copenhagen General Population Study. Using logistic regression adjusted for age, sex, smoking, and body-mass index, we investigated potential risk factors. We recruited 489 liver transplant recipients and 1808 controls. Among liver transplant recipients, 14 (2.9%) had hyperthyroidism compared with 21 (1.2%) of controls (adjusted odds ratio [aOR] 2.24, 95% confidence interval [CI] 1.05–4.75, P = 0.04), while 42 (5.7%) had hypothyroidism compared with 139 (7.7%) of controls (aOR 0.68, 95% CI 0.43–1.08, P = 0.10). Female sex, and autoimmune hepatitis and primary sclerosing cholangitis as causes of transplantation were associated with hyperthyroidism after adjustments. Age, female sex, and autoimmune liver diseases as cause of transplantation were associated with hypothyroidism after adjustments. DACOLT is registered in ClinicalTrials.gov (NCT04777032).
KW - Adult
KW - Female
KW - Humans
KW - Hyperthyroidism/epidemiology
KW - Hypothyroidism/etiology
KW - Liver Transplantation/adverse effects
KW - Male
KW - Prevalence
KW - Risk Factors
KW - Thyrotropin
U2 - 10.1038/s41598-024-58544-3
DO - 10.1038/s41598-024-58544-3
M3 - Journal article
C2 - 38570629
AN - SCOPUS:85189793367
SN - 2045-2322
VL - 14
JO - Scientific Reports
JF - Scientific Reports
M1 - 7828
ER -