Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study

Reimar W. Thomsen, Anil Mor, Jørgen Rungby, Sinna Pilgaard Ulrichsen, Jens Steen Nielsen, Jacob Stidsen, Søren Friborg, Ivan Brandslund, Jens Sandahl Christiansen, Henning Beck-Nielsen, Henrik Toft Sørensen

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

Resumé

Objectives: Levels of high-sensitivity C-reactive protein (CRP) are increased in patients with prevalent type 2 diabetes (T2D) and may predict coronary heart disease. There is limited knowledge of CRP levels among newly diagnosed T2D patients in the population-based setting. We determined the prevalence of elevated CRP in T2D patients included in the Danish DD2 study, and factors associated with such elevation.
Methods: Measurements of CRP were performed in the first 1,036 T2D patients included in the DD2 project, a large nationwide prospective research project enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We calculated median value and interquartile range of CRP, and examined the number of T2D patients within tertiles of CRP values, and within clinically relevant cutoff points of CRP (<1.0, 1.0–2.99, 3.0-5.99, or >=6.0 mg/L). We also examined demographic, clinical, and lifestyle characteristics associated with elevated CRP.
Results: The distribution of CRP was right skewed, with a median value of 2.1 mg/L (inter-tertile range, 1.3 - 3.6 mg/L). 20.6% of patients had a CRP level of 3.0 - 5.99 mg/L and 19.6% had a CRP of >=6 mg/L. As compared to the 361 people with CRP values in the lowest tertile (<= 1.3 mg/L), those with CRP values in the highest tertile (>3.6 mg/L) were younger (median age 58 vs. 62 years, p<0.0001) and more likely to be female (52.7% vs 39.3%, prevalence ratio 1.34 (95% CI: 1.18-1.50)). Patients in the highest CPR tertile had substantially higher median values of BMI (34.4 vs. 28.7 kg/m2, p<0.001) and waist circumference (113 cm vs. 100 cm, p<0.001), and were less likely to do regular sports activities (30.8% vs. 46.3%, prevalence ratio 0.67 (95% CI 0.47-0.86). They also had a higher median HbA1C (7.2 vs. 6.6%, p<0.01), higher fasting blood glucose (7.26 vs. 6.82 mmol/L, p<0.0001), higher C-peptide (784 vs. 545, p<0.0001), and were more likely to be on insulin treatment (7.7% vs. 5.0%, prevalence ratio 1.54 (95% CI: 0.96-2.13). Blood pressure, lipids, and current smoking were similar between groups. Patients with high CRP had higher Charlson comorbidity index scores (score >=1 in 35.2% vs. 26.1%) and more previous cardiovascular disease (20.4% vs. 16.9%) and chronic pulmonary disease (12.4% vs. 6.6%). Nonetheless, fewer in the elevated CRP group were on statin therapy (58.9% vs. 69.3%).
Conclusions: Among newly diagnosed T2D patients in Denmark, 19.6% had CRP values of more than 6 mg/L. Patients in the highest CRP tertile were more likely to be female, obese, physically inactive, and comorbid, with worse blood glucose control compared to those with low CRP.
OriginalsprogEngelsk
Publikationsdato18. jan. 2013
StatusUdgivet - 18. jan. 2013
BegivenhedDansk Endokrinologisk Selskabs Årsmøde 2013 - Aalborg, Danmark
Varighed: 18. jan. 201319. jan. 2013

Konference

KonferenceDansk Endokrinologisk Selskabs Årsmøde 2013
LandDanmark
ByAalborg
Periode18/01/201319/01/2013

Citer dette

Thomsen, R. W., Mor, A., Rungby, J., Ulrichsen, S. P., Nielsen, J. S., Stidsen, J., ... Sørensen, H. T. (2013). Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study. Abstract fra Dansk Endokrinologisk Selskabs Årsmøde 2013, Aalborg, Danmark.
Thomsen, Reimar W. ; Mor, Anil ; Rungby, Jørgen ; Ulrichsen, Sinna Pilgaard ; Nielsen, Jens Steen ; Stidsen, Jacob ; Friborg, Søren ; Brandslund, Ivan ; Christiansen, Jens Sandahl ; Beck-Nielsen, Henning ; Sørensen, Henrik Toft . / Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study. Abstract fra Dansk Endokrinologisk Selskabs Årsmøde 2013, Aalborg, Danmark.
@conference{f20073495591433799323de5c1bb593a,
title = "Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study",
abstract = "Objectives: Levels of high-sensitivity C-reactive protein (CRP) are increased in patients with prevalent type 2 diabetes (T2D) and may predict coronary heart disease. There is limited knowledge of CRP levels among newly diagnosed T2D patients in the population-based setting. We determined the prevalence of elevated CRP in T2D patients included in the Danish DD2 study, and factors associated with such elevation.Methods: Measurements of CRP were performed in the first 1,036 T2D patients included in the DD2 project, a large nationwide prospective research project enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We calculated median value and interquartile range of CRP, and examined the number of T2D patients within tertiles of CRP values, and within clinically relevant cutoff points of CRP (<1.0, 1.0–2.99, 3.0-5.99, or >=6.0 mg/L). We also examined demographic, clinical, and lifestyle characteristics associated with elevated CRP.Results: The distribution of CRP was right skewed, with a median value of 2.1 mg/L (inter-tertile range, 1.3 - 3.6 mg/L). 20.6{\%} of patients had a CRP level of 3.0 - 5.99 mg/L and 19.6{\%} had a CRP of >=6 mg/L. As compared to the 361 people with CRP values in the lowest tertile (<= 1.3 mg/L), those with CRP values in the highest tertile (>3.6 mg/L) were younger (median age 58 vs. 62 years, p<0.0001) and more likely to be female (52.7{\%} vs 39.3{\%}, prevalence ratio 1.34 (95{\%} CI: 1.18-1.50)). Patients in the highest CPR tertile had substantially higher median values of BMI (34.4 vs. 28.7 kg/m2, p<0.001) and waist circumference (113 cm vs. 100 cm, p<0.001), and were less likely to do regular sports activities (30.8{\%} vs. 46.3{\%}, prevalence ratio 0.67 (95{\%} CI 0.47-0.86). They also had a higher median HbA1C (7.2 vs. 6.6{\%}, p<0.01), higher fasting blood glucose (7.26 vs. 6.82 mmol/L, p<0.0001), higher C-peptide (784 vs. 545, p<0.0001), and were more likely to be on insulin treatment (7.7{\%} vs. 5.0{\%}, prevalence ratio 1.54 (95{\%} CI: 0.96-2.13). Blood pressure, lipids, and current smoking were similar between groups. Patients with high CRP had higher Charlson comorbidity index scores (score >=1 in 35.2{\%} vs. 26.1{\%}) and more previous cardiovascular disease (20.4{\%} vs. 16.9{\%}) and chronic pulmonary disease (12.4{\%} vs. 6.6{\%}). Nonetheless, fewer in the elevated CRP group were on statin therapy (58.9{\%} vs. 69.3{\%}).Conclusions: Among newly diagnosed T2D patients in Denmark, 19.6{\%} had CRP values of more than 6 mg/L. Patients in the highest CRP tertile were more likely to be female, obese, physically inactive, and comorbid, with worse blood glucose control compared to those with low CRP.",
author = "Thomsen, {Reimar W.} and Anil Mor and J{\o}rgen Rungby and Ulrichsen, {Sinna Pilgaard} and Nielsen, {Jens Steen} and Jacob Stidsen and S{\o}ren Friborg and Ivan Brandslund and Christiansen, {Jens Sandahl} and Henning Beck-Nielsen and S{\o}rensen, {Henrik Toft}",
year = "2013",
month = "1",
day = "18",
language = "English",
note = "null ; Conference date: 18-01-2013 Through 19-01-2013",

}

Thomsen, RW, Mor, A, Rungby, J, Ulrichsen, SP, Nielsen, JS, Stidsen, J, Friborg, S, Brandslund, I, Christiansen, JS, Beck-Nielsen, H & Sørensen, HT 2013, 'Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study', Dansk Endokrinologisk Selskabs Årsmøde 2013, Aalborg, Danmark, 18/01/2013 - 19/01/2013.

Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study. / Thomsen, Reimar W. ; Mor, Anil ; Rungby, Jørgen ; Ulrichsen, Sinna Pilgaard ; Nielsen, Jens Steen; Stidsen, Jacob; Friborg, Søren; Brandslund, Ivan; Christiansen, Jens Sandahl ; Beck-Nielsen, Henning; Sørensen, Henrik Toft .

2013. Abstract fra Dansk Endokrinologisk Selskabs Årsmøde 2013, Aalborg, Danmark.

Publikation: Konferencebidrag uden forlag/tidsskriftKonferenceabstrakt til konferenceForskning

TY - ABST

T1 - Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study

AU - Thomsen, Reimar W.

AU - Mor, Anil

AU - Rungby, Jørgen

AU - Ulrichsen, Sinna Pilgaard

AU - Nielsen, Jens Steen

AU - Stidsen, Jacob

AU - Friborg, Søren

AU - Brandslund, Ivan

AU - Christiansen, Jens Sandahl

AU - Beck-Nielsen, Henning

AU - Sørensen, Henrik Toft

PY - 2013/1/18

Y1 - 2013/1/18

N2 - Objectives: Levels of high-sensitivity C-reactive protein (CRP) are increased in patients with prevalent type 2 diabetes (T2D) and may predict coronary heart disease. There is limited knowledge of CRP levels among newly diagnosed T2D patients in the population-based setting. We determined the prevalence of elevated CRP in T2D patients included in the Danish DD2 study, and factors associated with such elevation.Methods: Measurements of CRP were performed in the first 1,036 T2D patients included in the DD2 project, a large nationwide prospective research project enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We calculated median value and interquartile range of CRP, and examined the number of T2D patients within tertiles of CRP values, and within clinically relevant cutoff points of CRP (<1.0, 1.0–2.99, 3.0-5.99, or >=6.0 mg/L). We also examined demographic, clinical, and lifestyle characteristics associated with elevated CRP.Results: The distribution of CRP was right skewed, with a median value of 2.1 mg/L (inter-tertile range, 1.3 - 3.6 mg/L). 20.6% of patients had a CRP level of 3.0 - 5.99 mg/L and 19.6% had a CRP of >=6 mg/L. As compared to the 361 people with CRP values in the lowest tertile (<= 1.3 mg/L), those with CRP values in the highest tertile (>3.6 mg/L) were younger (median age 58 vs. 62 years, p<0.0001) and more likely to be female (52.7% vs 39.3%, prevalence ratio 1.34 (95% CI: 1.18-1.50)). Patients in the highest CPR tertile had substantially higher median values of BMI (34.4 vs. 28.7 kg/m2, p<0.001) and waist circumference (113 cm vs. 100 cm, p<0.001), and were less likely to do regular sports activities (30.8% vs. 46.3%, prevalence ratio 0.67 (95% CI 0.47-0.86). They also had a higher median HbA1C (7.2 vs. 6.6%, p<0.01), higher fasting blood glucose (7.26 vs. 6.82 mmol/L, p<0.0001), higher C-peptide (784 vs. 545, p<0.0001), and were more likely to be on insulin treatment (7.7% vs. 5.0%, prevalence ratio 1.54 (95% CI: 0.96-2.13). Blood pressure, lipids, and current smoking were similar between groups. Patients with high CRP had higher Charlson comorbidity index scores (score >=1 in 35.2% vs. 26.1%) and more previous cardiovascular disease (20.4% vs. 16.9%) and chronic pulmonary disease (12.4% vs. 6.6%). Nonetheless, fewer in the elevated CRP group were on statin therapy (58.9% vs. 69.3%).Conclusions: Among newly diagnosed T2D patients in Denmark, 19.6% had CRP values of more than 6 mg/L. Patients in the highest CRP tertile were more likely to be female, obese, physically inactive, and comorbid, with worse blood glucose control compared to those with low CRP.

AB - Objectives: Levels of high-sensitivity C-reactive protein (CRP) are increased in patients with prevalent type 2 diabetes (T2D) and may predict coronary heart disease. There is limited knowledge of CRP levels among newly diagnosed T2D patients in the population-based setting. We determined the prevalence of elevated CRP in T2D patients included in the Danish DD2 study, and factors associated with such elevation.Methods: Measurements of CRP were performed in the first 1,036 T2D patients included in the DD2 project, a large nationwide prospective research project enrolling new T2D patients from general practitioners and hospital specialist outpatient clinics. We calculated median value and interquartile range of CRP, and examined the number of T2D patients within tertiles of CRP values, and within clinically relevant cutoff points of CRP (<1.0, 1.0–2.99, 3.0-5.99, or >=6.0 mg/L). We also examined demographic, clinical, and lifestyle characteristics associated with elevated CRP.Results: The distribution of CRP was right skewed, with a median value of 2.1 mg/L (inter-tertile range, 1.3 - 3.6 mg/L). 20.6% of patients had a CRP level of 3.0 - 5.99 mg/L and 19.6% had a CRP of >=6 mg/L. As compared to the 361 people with CRP values in the lowest tertile (<= 1.3 mg/L), those with CRP values in the highest tertile (>3.6 mg/L) were younger (median age 58 vs. 62 years, p<0.0001) and more likely to be female (52.7% vs 39.3%, prevalence ratio 1.34 (95% CI: 1.18-1.50)). Patients in the highest CPR tertile had substantially higher median values of BMI (34.4 vs. 28.7 kg/m2, p<0.001) and waist circumference (113 cm vs. 100 cm, p<0.001), and were less likely to do regular sports activities (30.8% vs. 46.3%, prevalence ratio 0.67 (95% CI 0.47-0.86). They also had a higher median HbA1C (7.2 vs. 6.6%, p<0.01), higher fasting blood glucose (7.26 vs. 6.82 mmol/L, p<0.0001), higher C-peptide (784 vs. 545, p<0.0001), and were more likely to be on insulin treatment (7.7% vs. 5.0%, prevalence ratio 1.54 (95% CI: 0.96-2.13). Blood pressure, lipids, and current smoking were similar between groups. Patients with high CRP had higher Charlson comorbidity index scores (score >=1 in 35.2% vs. 26.1%) and more previous cardiovascular disease (20.4% vs. 16.9%) and chronic pulmonary disease (12.4% vs. 6.6%). Nonetheless, fewer in the elevated CRP group were on statin therapy (58.9% vs. 69.3%).Conclusions: Among newly diagnosed T2D patients in Denmark, 19.6% had CRP values of more than 6 mg/L. Patients in the highest CRP tertile were more likely to be female, obese, physically inactive, and comorbid, with worse blood glucose control compared to those with low CRP.

M3 - Conference abstract for conference

ER -

Thomsen RW, Mor A, Rungby J, Ulrichsen SP, Nielsen JS, Stidsen J et al. Prevalence of elevated C-reactive protein among newly diagnosed type 2 diabetes patients in Denmark: Results from the population-based DD2 study. 2013. Abstract fra Dansk Endokrinologisk Selskabs Årsmøde 2013, Aalborg, Danmark.