Prevalence and severity of fatigue in adolescents and young adults with acquired brain injury

A nationwide study

Anne Norup*, Susanne Wulff Svendsen, Karoline Doser, Trine Okkerstrøm Ryttersgaard, Nicole Frandsen, Louise Gade, Hysse Birgitte Forchhammer

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Objective: To investigate the prevalence and severity of fatigue in adolescents and young adults with acquired brain injury (ABI) compared with healthy controls (HCs) and to examine associations between fatigue and gender, age and level of education. Methods: This cross-sectional study included 15–30 year old patients with ABI and a convenience sample of 15–30 year old HCs. All participants completed the 20-item Multidimensional Fatigue Inventory (MFI-20). Pathological fatigue was defined as “General Fatigue” ≥12. Adjusted mean differences between groups were calculated using multivariate analysis of covariance (MANCOVA). The adjusted prevalence proportion ratio (PPRadj) of pathological fatigue was calculated using Poisson regression. Results: The patients (n = 334) had higher scores than the HCs (n = 168) on all MFI-20 subscales with adjusted mean differences ranging from 1.7 to 4.7 and a higher prevalence of pathological fatigue (73% versus 29%), PPRadj 2.7 (95% confidence interval 2.1–3.5). Female patients experienced more fatigue than males on the “General Fatigue” and “Reduced Activity” subscales, while no gender differences were found in the HC group. Patients and HCs with elementary education had elevated scores on the “Reduced Activity” and “Mental Fatigue” subscales. Age was not associated with any of the subscale scores. Conclusion: Young patients with ABI had markedly higher prevalence and severity of fatigue than HCs. Age (15–30 years) was not associated with fatigue. No clear patterns of associations were evident with gender and level of education. Abbreviations: ABI: acquired brain injury; CI: confidence interval; GF: general fatigue; GOSE: Glasgow Outcome Scale Extended; HC: healthy control; MANCOVA: multivariate analysis of covariance; MF: mental fatigue; MFI-20: Multidimensional Fatigue Inventory-20; PF: physical fatigue; RA: reduced activity; RM: reduced motivation; TBI: traumatic brain injury

OriginalsprogEngelsk
TidsskriftNeuropsychological Rehabilitation
Vol/bind29
Udgave nummer7
Sider (fra-til)1113-1128
ISSN0960-2011
DOI
StatusUdgivet - 12. sep. 2019

Fingeraftryk

Young Adult
Multivariate Analysis
Young Adults
Fatigue
Brain Injury
Education
Confidence Intervals
Equipment and Supplies
Cross-Sectional Studies
Control Groups

Citer dette

Norup, Anne ; Svendsen, Susanne Wulff ; Doser, Karoline ; Ryttersgaard, Trine Okkerstrøm ; Frandsen, Nicole ; Gade, Louise ; Forchhammer, Hysse Birgitte. / Prevalence and severity of fatigue in adolescents and young adults with acquired brain injury : A nationwide study. I: Neuropsychological Rehabilitation. 2019 ; Bind 29, Nr. 7. s. 1113-1128.
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abstract = "Objective: To investigate the prevalence and severity of fatigue in adolescents and young adults with acquired brain injury (ABI) compared with healthy controls (HCs) and to examine associations between fatigue and gender, age and level of education. Methods: This cross-sectional study included 15–30 year old patients with ABI and a convenience sample of 15–30 year old HCs. All participants completed the 20-item Multidimensional Fatigue Inventory (MFI-20). Pathological fatigue was defined as “General Fatigue” ≥12. Adjusted mean differences between groups were calculated using multivariate analysis of covariance (MANCOVA). The adjusted prevalence proportion ratio (PPRadj) of pathological fatigue was calculated using Poisson regression. Results: The patients (n = 334) had higher scores than the HCs (n = 168) on all MFI-20 subscales with adjusted mean differences ranging from 1.7 to 4.7 and a higher prevalence of pathological fatigue (73{\%} versus 29{\%}), PPRadj 2.7 (95{\%} confidence interval 2.1–3.5). Female patients experienced more fatigue than males on the “General Fatigue” and “Reduced Activity” subscales, while no gender differences were found in the HC group. Patients and HCs with elementary education had elevated scores on the “Reduced Activity” and “Mental Fatigue” subscales. Age was not associated with any of the subscale scores. Conclusion: Young patients with ABI had markedly higher prevalence and severity of fatigue than HCs. Age (15–30 years) was not associated with fatigue. No clear patterns of associations were evident with gender and level of education. Abbreviations: ABI: acquired brain injury; CI: confidence interval; GF: general fatigue; GOSE: Glasgow Outcome Scale Extended; HC: healthy control; MANCOVA: multivariate analysis of covariance; MF: mental fatigue; MFI-20: Multidimensional Fatigue Inventory-20; PF: physical fatigue; RA: reduced activity; RM: reduced motivation; TBI: traumatic brain injury",
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Prevalence and severity of fatigue in adolescents and young adults with acquired brain injury : A nationwide study. / Norup, Anne; Svendsen, Susanne Wulff; Doser, Karoline; Ryttersgaard, Trine Okkerstrøm; Frandsen, Nicole; Gade, Louise; Forchhammer, Hysse Birgitte.

I: Neuropsychological Rehabilitation, Bind 29, Nr. 7, 12.09.2019, s. 1113-1128.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Prevalence and severity of fatigue in adolescents and young adults with acquired brain injury

T2 - A nationwide study

AU - Norup, Anne

AU - Svendsen, Susanne Wulff

AU - Doser, Karoline

AU - Ryttersgaard, Trine Okkerstrøm

AU - Frandsen, Nicole

AU - Gade, Louise

AU - Forchhammer, Hysse Birgitte

PY - 2019/9/12

Y1 - 2019/9/12

N2 - Objective: To investigate the prevalence and severity of fatigue in adolescents and young adults with acquired brain injury (ABI) compared with healthy controls (HCs) and to examine associations between fatigue and gender, age and level of education. Methods: This cross-sectional study included 15–30 year old patients with ABI and a convenience sample of 15–30 year old HCs. All participants completed the 20-item Multidimensional Fatigue Inventory (MFI-20). Pathological fatigue was defined as “General Fatigue” ≥12. Adjusted mean differences between groups were calculated using multivariate analysis of covariance (MANCOVA). The adjusted prevalence proportion ratio (PPRadj) of pathological fatigue was calculated using Poisson regression. Results: The patients (n = 334) had higher scores than the HCs (n = 168) on all MFI-20 subscales with adjusted mean differences ranging from 1.7 to 4.7 and a higher prevalence of pathological fatigue (73% versus 29%), PPRadj 2.7 (95% confidence interval 2.1–3.5). Female patients experienced more fatigue than males on the “General Fatigue” and “Reduced Activity” subscales, while no gender differences were found in the HC group. Patients and HCs with elementary education had elevated scores on the “Reduced Activity” and “Mental Fatigue” subscales. Age was not associated with any of the subscale scores. Conclusion: Young patients with ABI had markedly higher prevalence and severity of fatigue than HCs. Age (15–30 years) was not associated with fatigue. No clear patterns of associations were evident with gender and level of education. Abbreviations: ABI: acquired brain injury; CI: confidence interval; GF: general fatigue; GOSE: Glasgow Outcome Scale Extended; HC: healthy control; MANCOVA: multivariate analysis of covariance; MF: mental fatigue; MFI-20: Multidimensional Fatigue Inventory-20; PF: physical fatigue; RA: reduced activity; RM: reduced motivation; TBI: traumatic brain injury

AB - Objective: To investigate the prevalence and severity of fatigue in adolescents and young adults with acquired brain injury (ABI) compared with healthy controls (HCs) and to examine associations between fatigue and gender, age and level of education. Methods: This cross-sectional study included 15–30 year old patients with ABI and a convenience sample of 15–30 year old HCs. All participants completed the 20-item Multidimensional Fatigue Inventory (MFI-20). Pathological fatigue was defined as “General Fatigue” ≥12. Adjusted mean differences between groups were calculated using multivariate analysis of covariance (MANCOVA). The adjusted prevalence proportion ratio (PPRadj) of pathological fatigue was calculated using Poisson regression. Results: The patients (n = 334) had higher scores than the HCs (n = 168) on all MFI-20 subscales with adjusted mean differences ranging from 1.7 to 4.7 and a higher prevalence of pathological fatigue (73% versus 29%), PPRadj 2.7 (95% confidence interval 2.1–3.5). Female patients experienced more fatigue than males on the “General Fatigue” and “Reduced Activity” subscales, while no gender differences were found in the HC group. Patients and HCs with elementary education had elevated scores on the “Reduced Activity” and “Mental Fatigue” subscales. Age was not associated with any of the subscale scores. Conclusion: Young patients with ABI had markedly higher prevalence and severity of fatigue than HCs. Age (15–30 years) was not associated with fatigue. No clear patterns of associations were evident with gender and level of education. Abbreviations: ABI: acquired brain injury; CI: confidence interval; GF: general fatigue; GOSE: Glasgow Outcome Scale Extended; HC: healthy control; MANCOVA: multivariate analysis of covariance; MF: mental fatigue; MFI-20: Multidimensional Fatigue Inventory-20; PF: physical fatigue; RA: reduced activity; RM: reduced motivation; TBI: traumatic brain injury

KW - Age

KW - Gender

KW - Level of education

KW - Long-term outcome

KW - MFI-20

U2 - 10.1080/09602011.2017.1371045

DO - 10.1080/09602011.2017.1371045

M3 - Journal article

VL - 29

SP - 1113

EP - 1128

JO - Neuropsychological Rehabilitation

JF - Neuropsychological Rehabilitation

SN - 0960-2011

IS - 7

ER -