Prenatal phthalate exposures and anogenital distance in Swedish boys

Carl-Gustaf Bornehag, Fredrik Carlstedt, Bo Ag Jönsson, Christian H Lindh, Tina Kold Jensen, Anna Bodin, Carin Jonsson, Staffan Janson, Shanna H Swan

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

    136 Downloads (Pure)

    Abstrakt

    BACKGROUND: Phthalates are used as plasticizers in soft polyvinyl chloride (PVC) and in a large number of consumer products. Because of reported health risks, diisononyl phthalate (DiNP) has been introduced as a replacement for di(2-ethylhexyl) phthalate (DEHP) in soft PVC. This raises concerns because animal data suggest that DiNP may have antiandrogenic properties similar to those of DEHP. The anogenital distance (AGD)-the distance from the anus to the genitals-has been used to assess reproductive toxicity.

    OBJECTIVE: The objective of this study was to examine the associations between prenatal phthalate exposure and AGD in Swedish infants.

    METHODS: AGD was measured in 196 boys at 21 months of age, and first-trimester urine was analyzed for 10 phthalate metabolites of DEP (diethyl phthalate), DBP (dibutyl phthalate), DEHP, BBzP (benzylbutyl phthalate), as well as DiNP and creatinine. Data on covariates were collected by questionnaires.

    RESULTS: The most significant associations were found between the shorter of two AGD measures (anoscrotal distance; AGDas) and DiNP metabolites and strongest for oh-MMeOP [mono-(4-methyl-7-hydroxyloctyl) phthalate] and oxo-MMeOP [mono-(2-ethyl-5-oxohexyl) phthalate]. However, the AGDas reduction was small (4%) in relation to more than an interquartile range increase in DiNP exposure.

    CONCLUSIONS: These findings call into question the safety of substituting DiNP for DEHP in soft PVC, particularly because a shorter male AGD has been shown to relate to male genital birth defects in children and impaired reproductive function in adult males and the fact that human levels of DiNP are increasing globally.

    CITATION: Bornehag CG, Carlstedt F, Jönsson BA, Lindh CH, Jensen TK, Bodin A, Jonsson C, Janson S, Swan SH. 2015. Prenatal phthalate exposures and anogenital distance in Swedish boys. Environ Health Perspect 123:101-107; http://dx.doi.org/10.1289/ehp.1408163.

    OriginalsprogEngelsk
    TidsskriftEnvironmental Health Perspectives
    Vol/bind123
    Udgave nummer1
    Sider (fra-til)101-7
    Antal sider7
    ISSN0091-6765
    DOI
    StatusUdgivet - jan. 2015

    Fingeraftryk

    Dyk ned i forskningsemnerne om 'Prenatal phthalate exposures and anogenital distance in Swedish boys'. Sammen danner de et unikt fingeraftryk.

    Citationsformater