Prenatal maternal bereavement and congenital heart defects in offspring

A registry-based study

Jin Liang Zhu, Jørn Olsen, Henrik Toft Sørensen, Jiong Li, Ellen A. Nohr, Carsten Obel, Mogens Vestergaard, Morten Smærup Olsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

OBJECTIVES: It has been suggested that maternal emotional stress during cardiogenesis may be a risk factor for congenital heart defects (CHD). We examined this association using bereavement around the time of conception as an indicator of maternal exposure to stress in a large registry-based study.

METHODS: We identified 1,770,878 singletons born in Denmark from January 1, 1978, to December 31, 2008. Of these, 44,820 children were born to mothers who had lost a first-degree relative during the time period from 1 year before their last menstrual period until delivery (6080 mothers lost a child or partner, and 38,740 mothers lost a parent or sibling). CHD diagnoses were identified from the Danish Registry of Congenital Heart Disease. We used logistic regression models to calculate prevalence odds ratios (ORs) of CHD for exposed children compared with unexposed children.

RESULTS: Exposed children had a slightly higher prevalence of CHD than unexposed children (0.94% vs 0.82%; adjusted OR = 1.11, 95% confidence interval 1.00-1.22). The association was most marked for children of mothers who had lost a child or partner (1.15% vs 0.82%; adjusted OR = 1.32, 1.04-1.67).

CONCLUSIONS: Prenatal exposure to severe emotional stress may slightly increase the prevalence of CHD in offspring.

OriginalsprogEngelsk
TidsskriftPediatrics
Vol/bind131
Udgave nummer4
Sider (fra-til)e1225-30
ISSN0031-4005
DOI
StatusUdgivet - apr. 2013
Udgivet eksterntJa

Fingeraftryk

Registries
Mothers
Odds Ratio
Logistic Models
Maternal Exposure
Denmark
Siblings
Confidence Intervals

Citer dette

Zhu, J. L., Olsen, J., Sørensen, H. T., Li, J., Nohr, E. A., Obel, C., ... Olsen, M. S. (2013). Prenatal maternal bereavement and congenital heart defects in offspring: A registry-based study. Pediatrics, 131(4), e1225-30. https://doi.org/10.1542/peds.2012-3024
Zhu, Jin Liang ; Olsen, Jørn ; Sørensen, Henrik Toft ; Li, Jiong ; Nohr, Ellen A. ; Obel, Carsten ; Vestergaard, Mogens ; Olsen, Morten Smærup. / Prenatal maternal bereavement and congenital heart defects in offspring : A registry-based study. I: Pediatrics. 2013 ; Bind 131, Nr. 4. s. e1225-30.
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title = "Prenatal maternal bereavement and congenital heart defects in offspring: A registry-based study",
abstract = "OBJECTIVES: It has been suggested that maternal emotional stress during cardiogenesis may be a risk factor for congenital heart defects (CHD). We examined this association using bereavement around the time of conception as an indicator of maternal exposure to stress in a large registry-based study.METHODS: We identified 1,770,878 singletons born in Denmark from January 1, 1978, to December 31, 2008. Of these, 44,820 children were born to mothers who had lost a first-degree relative during the time period from 1 year before their last menstrual period until delivery (6080 mothers lost a child or partner, and 38,740 mothers lost a parent or sibling). CHD diagnoses were identified from the Danish Registry of Congenital Heart Disease. We used logistic regression models to calculate prevalence odds ratios (ORs) of CHD for exposed children compared with unexposed children.RESULTS: Exposed children had a slightly higher prevalence of CHD than unexposed children (0.94{\%} vs 0.82{\%}; adjusted OR = 1.11, 95{\%} confidence interval 1.00-1.22). The association was most marked for children of mothers who had lost a child or partner (1.15{\%} vs 0.82{\%}; adjusted OR = 1.32, 1.04-1.67).CONCLUSIONS: Prenatal exposure to severe emotional stress may slightly increase the prevalence of CHD in offspring.",
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Zhu, JL, Olsen, J, Sørensen, HT, Li, J, Nohr, EA, Obel, C, Vestergaard, M & Olsen, MS 2013, 'Prenatal maternal bereavement and congenital heart defects in offspring: A registry-based study', Pediatrics, bind 131, nr. 4, s. e1225-30. https://doi.org/10.1542/peds.2012-3024

Prenatal maternal bereavement and congenital heart defects in offspring : A registry-based study. / Zhu, Jin Liang; Olsen, Jørn; Sørensen, Henrik Toft; Li, Jiong; Nohr, Ellen A.; Obel, Carsten; Vestergaard, Mogens; Olsen, Morten Smærup.

I: Pediatrics, Bind 131, Nr. 4, 04.2013, s. e1225-30.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Prenatal maternal bereavement and congenital heart defects in offspring

T2 - A registry-based study

AU - Zhu, Jin Liang

AU - Olsen, Jørn

AU - Sørensen, Henrik Toft

AU - Li, Jiong

AU - Nohr, Ellen A.

AU - Obel, Carsten

AU - Vestergaard, Mogens

AU - Olsen, Morten Smærup

PY - 2013/4

Y1 - 2013/4

N2 - OBJECTIVES: It has been suggested that maternal emotional stress during cardiogenesis may be a risk factor for congenital heart defects (CHD). We examined this association using bereavement around the time of conception as an indicator of maternal exposure to stress in a large registry-based study.METHODS: We identified 1,770,878 singletons born in Denmark from January 1, 1978, to December 31, 2008. Of these, 44,820 children were born to mothers who had lost a first-degree relative during the time period from 1 year before their last menstrual period until delivery (6080 mothers lost a child or partner, and 38,740 mothers lost a parent or sibling). CHD diagnoses were identified from the Danish Registry of Congenital Heart Disease. We used logistic regression models to calculate prevalence odds ratios (ORs) of CHD for exposed children compared with unexposed children.RESULTS: Exposed children had a slightly higher prevalence of CHD than unexposed children (0.94% vs 0.82%; adjusted OR = 1.11, 95% confidence interval 1.00-1.22). The association was most marked for children of mothers who had lost a child or partner (1.15% vs 0.82%; adjusted OR = 1.32, 1.04-1.67).CONCLUSIONS: Prenatal exposure to severe emotional stress may slightly increase the prevalence of CHD in offspring.

AB - OBJECTIVES: It has been suggested that maternal emotional stress during cardiogenesis may be a risk factor for congenital heart defects (CHD). We examined this association using bereavement around the time of conception as an indicator of maternal exposure to stress in a large registry-based study.METHODS: We identified 1,770,878 singletons born in Denmark from January 1, 1978, to December 31, 2008. Of these, 44,820 children were born to mothers who had lost a first-degree relative during the time period from 1 year before their last menstrual period until delivery (6080 mothers lost a child or partner, and 38,740 mothers lost a parent or sibling). CHD diagnoses were identified from the Danish Registry of Congenital Heart Disease. We used logistic regression models to calculate prevalence odds ratios (ORs) of CHD for exposed children compared with unexposed children.RESULTS: Exposed children had a slightly higher prevalence of CHD than unexposed children (0.94% vs 0.82%; adjusted OR = 1.11, 95% confidence interval 1.00-1.22). The association was most marked for children of mothers who had lost a child or partner (1.15% vs 0.82%; adjusted OR = 1.32, 1.04-1.67).CONCLUSIONS: Prenatal exposure to severe emotional stress may slightly increase the prevalence of CHD in offspring.

KW - Adult

KW - Bereavement

KW - Denmark

KW - Female

KW - Heart Defects, Congenital

KW - Humans

KW - Infant, Newborn

KW - Logistic Models

KW - Male

KW - Odds Ratio

KW - Pregnancy

KW - Prevalence

KW - Registries

KW - Risk Factors

KW - Stress, Psychological

U2 - 10.1542/peds.2012-3024

DO - 10.1542/peds.2012-3024

M3 - Journal article

VL - 131

SP - e1225-30

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

ER -