Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

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Resumé

In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.

OriginalsprogEngelsk
TidsskriftReproductive toxicology (Elmsford, N.Y.)
Vol/bind68
Sider (fra-til)200-206
ISSN0890-6238
DOI
StatusUdgivet - 2017

Fingeraftryk

perfluorooctanoic acid
Sulfonic Acids
Mothers
Genitalia
Gestational Age
Pregnant Women
Confidence Intervals
Weights and Measures
Serum
perfluorooctane sulfonic acid
perfluorononanoic acid
perflexane
perfluorodecanoic acid

Citer dette

@article{0f7be6f77b1a4b1292bb460c6c87f092,
title = "Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort",
abstract = "In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95{\%} confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.",
author = "Lind, {Dorte Vesterholm} and L{\ae}rke Priskorn and Lassen, {Tina Harmer} and Flemming Nielsen and Kyhl, {Henriette Boye} and Kristensen, {David M{\o}bjerg} and Christesen, {Henrik Boye Thybo} and J{\o}rgensen, {Jan Steener} and Philippe Grandjean and Jensen, {Tina Kold}",
note = "Copyright {\circledC} 2016 Elsevier Inc. All rights reserved.",
year = "2017",
doi = "10.1016/j.reprotox.2016.08.019",
language = "English",
volume = "68",
pages = "200--206",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier",

}

TY - JOUR

T1 - Prenatal exposure to perfluoroalkyl substances and anogenital distance at 3 months of age in a Danish mother-child cohort

AU - Lind, Dorte Vesterholm

AU - Priskorn, Lærke

AU - Lassen, Tina Harmer

AU - Nielsen, Flemming

AU - Kyhl, Henriette Boye

AU - Kristensen, David Møbjerg

AU - Christesen, Henrik Boye Thybo

AU - Jørgensen, Jan Steener

AU - Grandjean, Philippe

AU - Jensen, Tina Kold

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2017

Y1 - 2017

N2 - In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.

AB - In the Odense child cohort, serum concentrations of perfluorooctanesulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) were measured in 638 pregnant women. Birth weight, head and abdominal circumferences and gestational age were determined. Anogenital distance (AGD), the distance from the anus to the genital organs, and penile width were measured 3 months after expected date of birth in 511 children. PFOS, PFHxS, PFNA and PFDA were associated with a decreased AGD in girls (p-trend<0.05) after adjusting for age and weight-for-age standard deviation score. PFOS in the highest quartile was associated with a 2.8mm (95% confidence intervals -4.5; -1.1) reduction in AGD in girls. No such tendencies were seen in boys. However, a tendency toward increased birth weight in girls and reduced birth weight in boys suggests that sex-dimorphic effects may occur from endocrine disrupting effects of these substances.

U2 - 10.1016/j.reprotox.2016.08.019

DO - 10.1016/j.reprotox.2016.08.019

M3 - Journal article

C2 - 27592399

VL - 68

SP - 200

EP - 206

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

ER -