Preliminary results of multiparametric magnetic resonance scan in combination with liquid biopsies performed on men suspected of prostate cancer.

Torben Brøchner Pedersen*, Mads Hvid Poulsen, Ole Graumann, Jon Thor Asmussen, Lars Lund


Publikation: Konferencebidrag uden forlag/tidsskriftPosterForskningpeer review


IntroductionProstate cancer (PC) is one of the most frequent malignancies among men, with approximately 4500 new cases diagnosed every year in Denmark. PC is responsible for more than 1000 deaths every year in Denmark. Pivotal to the successful treatment of PC is establishing an early diagnosis, which is currently performed by transrectal ultrasound guided biopsy from the prostate. Biopsies are associated with discomfort and severe complications. Some of these complications can, in rare cases, prove fatal. As the biopsies are taken randomly throughout the gland, the procedure has a high risk of false negative result. Multiparametric magnetic resonance imaging (mpMRI) has shown promising results in curbing some of these inadequacies. Combined with advances in the field of liquid biomarkers we seek to establish a new predictive model significantly reducing the need for prostate biopsies.
Materials & methodsWe plan to randomize a total of 456 men to either standard pathway (SP) or “mpMRI pathway (MP) in a 1:7 fashion. Blood and urine samples are taken prior to biopsies. We will perform a new type of biomarker sampling (liquid biopsy) on the collected urine and blood specimens. If suspicions lesions are found on the mpMRI additional targeted biopsy cores will be taken.Results, 41 men have completed the study with 37 randomised to MP and 4 to the standard pathway. 27.8% of men in MP had negative biopsy results compared with 50,0% in the SP. The negative predictive value of mpMRI was 80,0% (CI 59,3%- 93,17%) for Gleason Score > 6 PC, when using combined standard and targeted biopsies as reference test. The results of the liquid biopsies are still pending. 
ConclusionsOur preliminary results suggest that mpMRI adds importen additional information, that could better help select patients for biopsy. Combined with the results from the ´liquid biopsy´ we expect to be able to reduce the number of needed biopsies significantly
StatusUdgivet - 2019
BegivenhedDanish Cancer Research Days: Danske Kræftforskningsdage - Odense , Danmark
Varighed: 29. aug. 201930. aug. 2019
Konferencens nummer: 2


KonferenceDanish Cancer Research Days