Predictors of incident major depression in diabetic outpatients with subthreshold depression

Mariska Bot, Francois Pouwer, Johan Ormel, Joris P J Slaets, Peter de Jonge

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

AIMS: The objective of the study was to determine rates and risks of major depression in diabetes outpatients with subthreshold depression.

METHODS: This study is based on data of a stepped care-based intervention study in which diabetic patients with subthreshold depression were randomly allocated to low-intensity stepped care, aimed at reducing depressive symptoms, or to care as usual. Patients had a baseline Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16, but no baseline major depression according to the Mini International Neuropsychiatric Interview (MINI). Demographic, biological and psychological characteristics were collected at baseline. The MINI was used to determine whether participants had major depression during 2-year follow-up. Predictors of major depression were studied using logistic regression models.

RESULTS: Of the 114 patients included at baseline, 73 patients were available at 2-year follow-up. The 2-year incidence of major depression was 42% (n=31). Higher baseline anxiety levels [odds ratio (OR)=1.25; 95% confidence interval (CI), 1.04-1.50; P=0.018] and depression severity levels (OR=1.09; 95% CI, 1.00-1.18; P=0.045) were predictors of incident major depression. Stepped care allocation was not related to incident major depression. In multivariable models, similar results were found.

CONCLUSIONS: Having a higher baseline level of anxiety and depression appeared to be related to incident major depression during 2-year follow-up in diabetic patients with subthreshold depression. A stepped care intervention aimed at depression alone did not prevent the onset of depression in these patients. Besides level of depression, anxiety might be taken into account in the prevention of major depression in diabetic patients with subthreshold depression.

OriginalsprogEngelsk
TidsskriftDiabetic Medicine Online
Vol/bind27
Udgave nummer11
Sider (fra-til)1295-301
Antal sider7
ISSN1464-5491
DOI
StatusUdgivet - nov. 2010

Fingeraftryk

Outpatients
Depression
Logistic Models
Odds Ratio
Confidence Intervals
Epidemiologic Studies

Citer dette

Bot, Mariska ; Pouwer, Francois ; Ormel, Johan ; Slaets, Joris P J ; de Jonge, Peter. / Predictors of incident major depression in diabetic outpatients with subthreshold depression. I: Diabetic Medicine Online. 2010 ; Bind 27, Nr. 11. s. 1295-301.
@article{35a8ed5e44784099ba9fa10397e255d5,
title = "Predictors of incident major depression in diabetic outpatients with subthreshold depression",
abstract = "AIMS: The objective of the study was to determine rates and risks of major depression in diabetes outpatients with subthreshold depression.METHODS: This study is based on data of a stepped care-based intervention study in which diabetic patients with subthreshold depression were randomly allocated to low-intensity stepped care, aimed at reducing depressive symptoms, or to care as usual. Patients had a baseline Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16, but no baseline major depression according to the Mini International Neuropsychiatric Interview (MINI). Demographic, biological and psychological characteristics were collected at baseline. The MINI was used to determine whether participants had major depression during 2-year follow-up. Predictors of major depression were studied using logistic regression models.RESULTS: Of the 114 patients included at baseline, 73 patients were available at 2-year follow-up. The 2-year incidence of major depression was 42{\%} (n=31). Higher baseline anxiety levels [odds ratio (OR)=1.25; 95{\%} confidence interval (CI), 1.04-1.50; P=0.018] and depression severity levels (OR=1.09; 95{\%} CI, 1.00-1.18; P=0.045) were predictors of incident major depression. Stepped care allocation was not related to incident major depression. In multivariable models, similar results were found.CONCLUSIONS: Having a higher baseline level of anxiety and depression appeared to be related to incident major depression during 2-year follow-up in diabetic patients with subthreshold depression. A stepped care intervention aimed at depression alone did not prevent the onset of depression in these patients. Besides level of depression, anxiety might be taken into account in the prevention of major depression in diabetic patients with subthreshold depression.",
keywords = "Aged, Depressive Disorder, Major, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Humans, Male, Netherlands, Quality of Life, Severity of Illness Index, Surveys and Questionnaires, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't",
author = "Mariska Bot and Francois Pouwer and Johan Ormel and Slaets, {Joris P J} and {de Jonge}, Peter",
note = "{\circledC} 2010 The Authors. Diabetic Medicine {\circledC} 2010 Diabetes UK.",
year = "2010",
month = "11",
doi = "10.1111/j.1464-5491.2010.03119.x",
language = "English",
volume = "27",
pages = "1295--301",
journal = "Diabetic Medicine Online",
issn = "1464-5491",
publisher = "Wiley-Blackwell",
number = "11",

}

Predictors of incident major depression in diabetic outpatients with subthreshold depression. / Bot, Mariska; Pouwer, Francois; Ormel, Johan; Slaets, Joris P J; de Jonge, Peter.

I: Diabetic Medicine Online, Bind 27, Nr. 11, 11.2010, s. 1295-301.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Predictors of incident major depression in diabetic outpatients with subthreshold depression

AU - Bot, Mariska

AU - Pouwer, Francois

AU - Ormel, Johan

AU - Slaets, Joris P J

AU - de Jonge, Peter

N1 - © 2010 The Authors. Diabetic Medicine © 2010 Diabetes UK.

PY - 2010/11

Y1 - 2010/11

N2 - AIMS: The objective of the study was to determine rates and risks of major depression in diabetes outpatients with subthreshold depression.METHODS: This study is based on data of a stepped care-based intervention study in which diabetic patients with subthreshold depression were randomly allocated to low-intensity stepped care, aimed at reducing depressive symptoms, or to care as usual. Patients had a baseline Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16, but no baseline major depression according to the Mini International Neuropsychiatric Interview (MINI). Demographic, biological and psychological characteristics were collected at baseline. The MINI was used to determine whether participants had major depression during 2-year follow-up. Predictors of major depression were studied using logistic regression models.RESULTS: Of the 114 patients included at baseline, 73 patients were available at 2-year follow-up. The 2-year incidence of major depression was 42% (n=31). Higher baseline anxiety levels [odds ratio (OR)=1.25; 95% confidence interval (CI), 1.04-1.50; P=0.018] and depression severity levels (OR=1.09; 95% CI, 1.00-1.18; P=0.045) were predictors of incident major depression. Stepped care allocation was not related to incident major depression. In multivariable models, similar results were found.CONCLUSIONS: Having a higher baseline level of anxiety and depression appeared to be related to incident major depression during 2-year follow-up in diabetic patients with subthreshold depression. A stepped care intervention aimed at depression alone did not prevent the onset of depression in these patients. Besides level of depression, anxiety might be taken into account in the prevention of major depression in diabetic patients with subthreshold depression.

AB - AIMS: The objective of the study was to determine rates and risks of major depression in diabetes outpatients with subthreshold depression.METHODS: This study is based on data of a stepped care-based intervention study in which diabetic patients with subthreshold depression were randomly allocated to low-intensity stepped care, aimed at reducing depressive symptoms, or to care as usual. Patients had a baseline Center for Epidemiologic Studies Depression Scale (CES-D) score ≥ 16, but no baseline major depression according to the Mini International Neuropsychiatric Interview (MINI). Demographic, biological and psychological characteristics were collected at baseline. The MINI was used to determine whether participants had major depression during 2-year follow-up. Predictors of major depression were studied using logistic regression models.RESULTS: Of the 114 patients included at baseline, 73 patients were available at 2-year follow-up. The 2-year incidence of major depression was 42% (n=31). Higher baseline anxiety levels [odds ratio (OR)=1.25; 95% confidence interval (CI), 1.04-1.50; P=0.018] and depression severity levels (OR=1.09; 95% CI, 1.00-1.18; P=0.045) were predictors of incident major depression. Stepped care allocation was not related to incident major depression. In multivariable models, similar results were found.CONCLUSIONS: Having a higher baseline level of anxiety and depression appeared to be related to incident major depression during 2-year follow-up in diabetic patients with subthreshold depression. A stepped care intervention aimed at depression alone did not prevent the onset of depression in these patients. Besides level of depression, anxiety might be taken into account in the prevention of major depression in diabetic patients with subthreshold depression.

KW - Aged

KW - Depressive Disorder, Major

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Humans

KW - Male

KW - Netherlands

KW - Quality of Life

KW - Severity of Illness Index

KW - Surveys and Questionnaires

KW - Journal Article

KW - Multicenter Study

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1464-5491.2010.03119.x

DO - 10.1111/j.1464-5491.2010.03119.x

M3 - Journal article

VL - 27

SP - 1295

EP - 1301

JO - Diabetic Medicine Online

JF - Diabetic Medicine Online

SN - 1464-5491

IS - 11

ER -