Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study

Jorrit L Opstelten, Simon S M Chan, Andrew R Hart, Fiona D M van Schaik, Peter D Siersema, Eef G W M Lentjes, Kay-Tee Khaw, Robert Luben, Timothy J Key, Heiner Boeing, Manuela M Bergmann, Kim Overvad, Domenico Palli, Giovanna Masala, Antoine Racine, Franck Carbonnel, Marie-Christine Boutron-Ruault, Anne Tjønneland, Anja Olsen, Vibeke AndersenRudolf Kaaks, Tilman Kühn, Rosario Tumino, Antonia Trichopoulou, Petra H M Peeters, W M Monique Verschuren, Ben J M Witteman, Bas Oldenburg

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Resumé

Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).

Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.

Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).

Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind24
Udgave nummer3
Sider (fra-til)633-640
ISSN1078-0998
DOI
StatusUdgivet - 2018

Fingeraftryk

Ulcerative Colitis
Crohn Disease
Case-Control Studies
Serum
Population
Inflammatory Bowel Diseases
Tandem Mass Spectrometry
Liquid Chromatography
Logistic Models
Food
Neoplasms

Citer dette

Opstelten, J. L., Chan, S. S. M., Hart, A. R., van Schaik, F. D. M., Siersema, P. D., Lentjes, E. G. W. M., ... Oldenburg, B. (2018). Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study. Inflammatory Bowel Diseases, 24(3), 633-640. https://doi.org/10.1093/ibd/izx050
Opstelten, Jorrit L ; Chan, Simon S M ; Hart, Andrew R ; van Schaik, Fiona D M ; Siersema, Peter D ; Lentjes, Eef G W M ; Khaw, Kay-Tee ; Luben, Robert ; Key, Timothy J ; Boeing, Heiner ; Bergmann, Manuela M ; Overvad, Kim ; Palli, Domenico ; Masala, Giovanna ; Racine, Antoine ; Carbonnel, Franck ; Boutron-Ruault, Marie-Christine ; Tjønneland, Anne ; Olsen, Anja ; Andersen, Vibeke ; Kaaks, Rudolf ; Kühn, Tilman ; Tumino, Rosario ; Trichopoulou, Antonia ; Peeters, Petra H M ; Verschuren, W M Monique ; Witteman, Ben J M ; Oldenburg, Bas. / Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations : A Nested Case-Control Study. I: Inflammatory Bowel Diseases. 2018 ; Bind 24, Nr. 3. s. 633-640.
@article{8831368eb25f4a4286e4dc7559c1521a,
title = "Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study",
abstract = "Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.",
keywords = "Crohn's disease, Vitamin D, etiology, inflammatory bowel disease, ulcerative colitis",
author = "Opstelten, {Jorrit L} and Chan, {Simon S M} and Hart, {Andrew R} and {van Schaik}, {Fiona D M} and Siersema, {Peter D} and Lentjes, {Eef G W M} and Kay-Tee Khaw and Robert Luben and Key, {Timothy J} and Heiner Boeing and Bergmann, {Manuela M} and Kim Overvad and Domenico Palli and Giovanna Masala and Antoine Racine and Franck Carbonnel and Marie-Christine Boutron-Ruault and Anne Tj{\o}nneland and Anja Olsen and Vibeke Andersen and Rudolf Kaaks and Tilman K{\"u}hn and Rosario Tumino and Antonia Trichopoulou and Peeters, {Petra H M} and Verschuren, {W M Monique} and Witteman, {Ben J M} and Bas Oldenburg",
year = "2018",
doi = "10.1093/ibd/izx050",
language = "English",
volume = "24",
pages = "633--640",
journal = "Inflammatory Bowel Diseases",
issn = "1078-0998",
publisher = "Lippincott Williams & Wilkins",
number = "3",

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Opstelten, JL, Chan, SSM, Hart, AR, van Schaik, FDM, Siersema, PD, Lentjes, EGWM, Khaw, K-T, Luben, R, Key, TJ, Boeing, H, Bergmann, MM, Overvad, K, Palli, D, Masala, G, Racine, A, Carbonnel, F, Boutron-Ruault, M-C, Tjønneland, A, Olsen, A, Andersen, V, Kaaks, R, Kühn, T, Tumino, R, Trichopoulou, A, Peeters, PHM, Verschuren, WMM, Witteman, BJM & Oldenburg, B 2018, 'Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations: A Nested Case-Control Study', Inflammatory Bowel Diseases, bind 24, nr. 3, s. 633-640. https://doi.org/10.1093/ibd/izx050

Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations : A Nested Case-Control Study. / Opstelten, Jorrit L; Chan, Simon S M; Hart, Andrew R; van Schaik, Fiona D M; Siersema, Peter D; Lentjes, Eef G W M; Khaw, Kay-Tee; Luben, Robert; Key, Timothy J; Boeing, Heiner; Bergmann, Manuela M; Overvad, Kim; Palli, Domenico; Masala, Giovanna; Racine, Antoine; Carbonnel, Franck; Boutron-Ruault, Marie-Christine; Tjønneland, Anne; Olsen, Anja; Andersen, Vibeke; Kaaks, Rudolf; Kühn, Tilman; Tumino, Rosario; Trichopoulou, Antonia; Peeters, Petra H M; Verschuren, W M Monique; Witteman, Ben J M; Oldenburg, Bas.

I: Inflammatory Bowel Diseases, Bind 24, Nr. 3, 2018, s. 633-640.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Prediagnostic Serum Vitamin D Levels and the Risk of Crohn's Disease and Ulcerative Colitis in European Populations

T2 - A Nested Case-Control Study

AU - Opstelten, Jorrit L

AU - Chan, Simon S M

AU - Hart, Andrew R

AU - van Schaik, Fiona D M

AU - Siersema, Peter D

AU - Lentjes, Eef G W M

AU - Khaw, Kay-Tee

AU - Luben, Robert

AU - Key, Timothy J

AU - Boeing, Heiner

AU - Bergmann, Manuela M

AU - Overvad, Kim

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Racine, Antoine

AU - Carbonnel, Franck

AU - Boutron-Ruault, Marie-Christine

AU - Tjønneland, Anne

AU - Olsen, Anja

AU - Andersen, Vibeke

AU - Kaaks, Rudolf

AU - Kühn, Tilman

AU - Tumino, Rosario

AU - Trichopoulou, Antonia

AU - Peeters, Petra H M

AU - Verschuren, W M Monique

AU - Witteman, Ben J M

AU - Oldenburg, Bas

PY - 2018

Y1 - 2018

N2 - Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

AB - Background: A low vitamin D status has been put forward as a potential risk factor for the development of inflammatory bowel disease (IBD). This study investigated the association between prediagnostic circulating vitamin D concentrations and dietary intakes of vitamin D, and the risk of Crohn's disease (CD) and ulcerative colitis (UC).Methods: Among 359,728 participants of the European Prospective Investigation into Cancer and Nutrition cohort, individuals who developed CD or UC after enrollment were identified. Each case was matched with2 controls by center, gender, age, date of recruitment, and follow-up time. At cohort entry, blood samples were collected and dietary vitamin D intakes were obtained from validated food frequency questionnaires. Serum 25-hydroxyvitamin D levels were measured using liquid chromatography-tandem mass spectrometry. Conditional logistic regression was performed to determine the odds of CD and UC.Results: Seventy-two participants developed CD and 169 participants developed UC after a median follow-up of 4.7 and 4.1 years, respectively. Compared with the lowest quartile, no associations with the 3 higher quartiles of vitamin D concentrations were observed for CD (p trend = 0.34) or UC (p trend = 0.66). Similarly, no associations were detected when serum vitamin D levels were analyzed as a continuous variable. Dietary vitamin D intakes were not associated with CD (p trend = 0.39) or UC (p trend = 0.83).Conclusions: Vitamin D status was not associated with the development of CD or UC. This does not suggest a major role for vitamin D deficiency in the etiology of IBD, although larger studies are needed to confirm these findings.

KW - Crohn's disease

KW - Vitamin D

KW - etiology

KW - inflammatory bowel disease

KW - ulcerative colitis

U2 - 10.1093/ibd/izx050

DO - 10.1093/ibd/izx050

M3 - Journal article

C2 - 29462382

VL - 24

SP - 633

EP - 640

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 3

ER -