Power estimations for non-primary outcomes in randomised clinical trials

Janus Christian Jakobsen, Christian Ovesen, Per Winkel, Jørgen Hilden, Christian Gluud, Jørn Wetterslev

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Abstrakt

OBJECTIVE AND METHODS: It is rare that trialists report power estimations of non-primary outcomes. In the present article, we will describe how to define a valid hierarchy of outcomes in a randomised clinical trial, to limit problems with Type I and Type II errors, using considerations on the clinical relevance of the outcomes and power estimations.

CONCLUSION: Power estimations of non-primary outcomes may guide trialists in classifying non-primary outcomes as secondary or exploratory. The power estimations are simple and if they are used systematically, more appropriate outcome hierarchies can be defined, and trial results will become more interpretable.

OriginalsprogEngelsk
Artikelnummere027092
TidsskriftBMJ Open
Vol/bind9
Udgave nummer6
Antal sider3
ISSN2044-6055
DOI
StatusUdgivet - 6. jun. 2019

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Citationsformater

Jakobsen, J. C., Ovesen, C., Winkel, P., Hilden, J., Gluud, C., & Wetterslev, J. (2019). Power estimations for non-primary outcomes in randomised clinical trials. BMJ Open, 9(6), [e027092]. https://doi.org/10.1136/bmjopen-2018-027092