TY - JOUR
T1 - Potential role of non-antibiotics (helper compounds) in the treatment of multidrug-resistant Gram-negative infections
T2 - mechanisms for their direct and indirect activities
AU - Martins, Marta
AU - Dastidar, Sujata G
AU - Fanning, Seamus
AU - Kristiansen, Jette E
AU - Molnar, Joseph
AU - Pagès, Jean-Marie
AU - Schelz, Zsuzsanna
AU - Spengler, Gabriella
AU - Viveiros, Miguel
AU - Amaral, Leonard
PY - 2008/3/1
Y1 - 2008/3/1
N2 - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.
AB - Multidrug resistance in Gram-negative bacteria is now known to be primarily caused by overexpression of efflux pumps that extrude unrelated antibiotics from the periplasm or cytoplasm of the bacterium prior to their reaching their intended target. This review focuses on a variety of agents that have been shown to be efflux pump inhibitors (EPIs) and which, if used as 'helper compounds' in combination with antibiotics to which the organism is initially resistant, may produce the required cure. Although not all of the EPIs may serve a helper role owing to their toxicity, they may nevertheless serve as lead compounds.
KW - Anti-Bacterial Agents
KW - Drug Resistance, Multiple, Bacterial
KW - Enzyme Inhibitors
KW - Gram-Negative Bacterial Infections
KW - Humans
U2 - 10.1016/j.ijantimicag.2007.10.025
DO - 10.1016/j.ijantimicag.2007.10.025
M3 - Journal article
C2 - 18180147
SN - 0924-8579
VL - 31
SP - 198
EP - 208
JO - International Journal of Antimicrobial Agents
JF - International Journal of Antimicrobial Agents
IS - 3
ER -