Possible role of vascular intima for generation of coagulant activity in patients undergoing coronary thrombolysis with recombinant tissue-type plasminogen activator. A randomized, placebo-controlled study

S. Munkvad*, J. Gram, J. Jespersen

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

In our present placebo-controlled study on recombinant tissue-type plasminogen activator (rt-PA) and heparin treatment of patients with acute ischaemic heart disease (IHD), we studied the extent of fibrin resolution and generation of coagulant activity. In rt-PA treated patients the lysis of fibrin in vivo (median 60 nmol of fibrin-estimated as fibrinogen equivalents) was significantly higher (p <0.02) than can be accounted for solely by lysis of a coronary thrombus (approximately 2 nmol) and circulating soluble fibrin (median 15 nmol). We observed a 200% increase of plasma concentrations of both prothrombin fragment 1+2 (p <0.001) and thrombin-antithrombin III complexes (p <0.001) as a consequence of rt-PA treatment, indicating that the coagulant activity is primarily caused by a physiological activation of the coagulation system. We conclude that an important contribution to the activation of coagulation in patients undergoing coronary thrombolysis is lysis of fibrin deposited widespread on the vascular intima, and that this process causes an intimal-dependent activation of the coagulation system.

OriginalsprogEngelsk
BogserieScandinavian Journal of Clinical and Laboratory Investigation
Vol/bind51
Udgave nummer7
Sider (fra-til)581-590
Antal sider10
ISSN0036-5513
DOI
StatusUdgivet - 1991

Fingeraftryk Dyk ned i forskningsemnerne om 'Possible role of vascular intima for generation of coagulant activity in patients undergoing coronary thrombolysis with recombinant tissue-type plasminogen activator. A randomized, placebo-controlled study'. Sammen danner de et unikt fingeraftryk.

Citationsformater