@article{12a41924754945929214d727bb229c0e,
title = "Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-triggered nanoaggregation probe",
abstract = "Drug Design: An (18)F-labeled caspase-3-sensitive nanoaggregation positron emission tomography tracer was prepared and evaluated for imaging the caspase-3 activity in doxorubicin-treated tumor xenografts. Enhanced retention of the (18)F activity in apoptotic tumors is achieved through intramolecular macrocyclization and in situ aggregation upon caspase-3 activation (see picture).",
keywords = "Animals, Apoptosis/drug effects, Benzothiazoles/chemistry, Caspase 3/metabolism, Diagnostic Imaging/methods, Fluorine Radioisotopes/chemistry, HeLa Cells, Heterografts, Humans, Mice, Molecular Structure, Nanostructures/chemistry, Neoplasms/diagnostic imaging, Oligopeptides/chemistry, Positron-Emission Tomography/methods, Radiopharmaceuticals",
author = "Bin Shen and Jongho Jeon and Mikael Palner and Deju Ye and Adam Shuhendler and Chin, {Frederick T} and Jianghong Rao",
note = "Copyright {\textcopyright} 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2013",
month = sep,
day = "27",
doi = "10.1002/anie.201303422",
language = "English",
volume = "52",
pages = "10511--10514",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley",
number = "40",
}