Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries

Xun Qian, Michael Francis, Ralf Köhler, Viktoriya Solodushko, Mike Lin, Mark S Taylor

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients from internal stores or plasma membrane channels promotes arterial hyperpolarization and vasodilation. Here, we assess arteries from genetically altered IK1 knockout mice (IK1(-/-)) to determine whether IK1 channels exert a positive feedback influence on endothelial Ca(2+) dynamics.
OriginalsprogEngelsk
TidsskriftArteriosclerosis, Thrombosis, and Vascular Biology
Vol/bind34
Udgave nummer1
Sider (fra-til)127-135
Antal sider9
ISSN1079-5642
DOI
StatusUdgivet - jan. 2014

Fingeraftryk

Vasodilation
Cell Membrane

Citer dette

Qian, Xun ; Francis, Michael ; Köhler, Ralf ; Solodushko, Viktoriya ; Lin, Mike ; Taylor, Mark S. / Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries. I: Arteriosclerosis, Thrombosis, and Vascular Biology. 2014 ; Bind 34, Nr. 1. s. 127-135 .
@article{8627265b47ab42ee92fa1e617bb7d414,
title = "Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries",
abstract = "Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients from internal stores or plasma membrane channels promotes arterial hyperpolarization and vasodilation. Here, we assess arteries from genetically altered IK1 knockout mice (IK1(-/-)) to determine whether IK1 channels exert a positive feedback influence on endothelial Ca(2+) dynamics.",
author = "Xun Qian and Michael Francis and Ralf K{\"o}hler and Viktoriya Solodushko and Mike Lin and Taylor, {Mark S}",
year = "2014",
month = "1",
doi = "10.1161/ATVBAHA.113.302506",
language = "English",
volume = "34",
pages = "127--135",
journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",
issn = "1079-5642",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries. / Qian, Xun; Francis, Michael; Köhler, Ralf; Solodushko, Viktoriya; Lin, Mike; Taylor, Mark S.

I: Arteriosclerosis, Thrombosis, and Vascular Biology, Bind 34, Nr. 1, 01.2014, s. 127-135 .

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Positive Feedback Regulation of Agonist-Stimulated Endothelial Ca2+ Dynamics by KCa3.1 Channels in Mouse Mesenteric Arteries

AU - Qian, Xun

AU - Francis, Michael

AU - Köhler, Ralf

AU - Solodushko, Viktoriya

AU - Lin, Mike

AU - Taylor, Mark S

PY - 2014/1

Y1 - 2014/1

N2 - Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients from internal stores or plasma membrane channels promotes arterial hyperpolarization and vasodilation. Here, we assess arteries from genetically altered IK1 knockout mice (IK1(-/-)) to determine whether IK1 channels exert a positive feedback influence on endothelial Ca(2+) dynamics.

AB - Intermediate and small conductance KCa channels IK1 (KCa3.1) and SK3 (KCa2.3) are primary targets of endothelial Ca(2+) signals in the arterial vasculature, and their ablation results in increased arterial tone and hypertension. Activation of IK1 channels by local Ca(2+) transients from internal stores or plasma membrane channels promotes arterial hyperpolarization and vasodilation. Here, we assess arteries from genetically altered IK1 knockout mice (IK1(-/-)) to determine whether IK1 channels exert a positive feedback influence on endothelial Ca(2+) dynamics.

U2 - 10.1161/ATVBAHA.113.302506

DO - 10.1161/ATVBAHA.113.302506

M3 - Journal article

VL - 34

SP - 127

EP - 135

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

SN - 1079-5642

IS - 1

ER -