Resumé
BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.
MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.
RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.
CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | In Vivo |
| Vol/bind | 28 |
| Udgave nummer | 2 |
| Sider (fra-til) | 173-84 |
| Antal sider | 12 |
| ISSN | 0258-851X |
| Status | Udgivet - 19. mar. 2014 |
Fingeraftryk
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Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. / Darusman, Huda S; Pandelaki, Jacub; Mulyadi, Rahmad; Sajuthi, Dondin; Putri, Indah A; Kalliokoski, Otto H; Call, Josep; Abelson, Klas S P; Schapiro, Steven J; Gjedde, Albert; Hau, Jann.
I: In Vivo, Bind 28, Nr. 2, 19.03.2014, s. 173-84.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
TY - JOUR
T1 - Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid
AU - Darusman, Huda S
AU - Pandelaki, Jacub
AU - Mulyadi, Rahmad
AU - Sajuthi, Dondin
AU - Putri, Indah A
AU - Kalliokoski, Otto H
AU - Call, Josep
AU - Abelson, Klas S P
AU - Schapiro, Steven J
AU - Gjedde, Albert
AU - Hau, Jann
PY - 2014/3/19
Y1 - 2014/3/19
N2 - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.
AB - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.
KW - Age Factors
KW - Aging
KW - Alzheimer Disease/metabolism
KW - Amyloid beta-Peptides/cerebrospinal fluid
KW - Animals
KW - Atrophy
KW - Biomarkers
KW - Disease Models, Animal
KW - Female
KW - Hippocampus/pathology
KW - Macaca fascicularis
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory
KW - tau Proteins/cerebrospinal fluid
M3 - Journal article
VL - 28
SP - 173
EP - 184
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 2
ER -