Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid

Huda S Darusman, Jacub Pandelaki, Rahmad Mulyadi, Dondin Sajuthi, Indah A Putri, Otto H Kalliokoski, Josep Call, Klas S P Abelson, Steven J Schapiro, Albert Gjedde, Jann Hau

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.

MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.

RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.

CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

OriginalsprogEngelsk
TidsskriftIn Vivo
Vol/bind28
Udgave nummer2
Sider (fra-til)173-84
Antal sider12
ISSN0258-851X
StatusUdgivet - 19. mar. 2014

Fingeraftryk

Cerebrospinal fluid
tau Proteins
Macaca fascicularis
Primates
Cerebrospinal Fluid
Data storage equipment
Neurodegenerative Diseases
Neurodegenerative diseases
Alzheimer Disease
Biomarkers
Pathology
Magnetic resonance
Amyloid
Amino Acids
Brain
Animals
Imaging techniques
amyloid beta-protein (1-42)

Citer dette

Darusman, H. S., Pandelaki, J., Mulyadi, R., Sajuthi, D., Putri, I. A., Kalliokoski, O. H., ... Hau, J. (2014). Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. In Vivo, 28(2), 173-84.
Darusman, Huda S ; Pandelaki, Jacub ; Mulyadi, Rahmad ; Sajuthi, Dondin ; Putri, Indah A ; Kalliokoski, Otto H ; Call, Josep ; Abelson, Klas S P ; Schapiro, Steven J ; Gjedde, Albert ; Hau, Jann. / Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. I: In Vivo. 2014 ; Bind 28, Nr. 2. s. 173-84.
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title = "Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid",
abstract = "BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.",
keywords = "Age Factors, Aging, Alzheimer Disease/metabolism, Amyloid beta-Peptides/cerebrospinal fluid, Animals, Atrophy, Biomarkers, Disease Models, Animal, Female, Hippocampus/pathology, Macaca fascicularis, Magnetic Resonance Imaging, Male, Memory, tau Proteins/cerebrospinal fluid",
author = "Darusman, {Huda S} and Jacub Pandelaki and Rahmad Mulyadi and Dondin Sajuthi and Putri, {Indah A} and Kalliokoski, {Otto H} and Josep Call and Abelson, {Klas S P} and Schapiro, {Steven J} and Albert Gjedde and Jann Hau",
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journal = "In Vivo",
issn = "0258-851X",
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Darusman, HS, Pandelaki, J, Mulyadi, R, Sajuthi, D, Putri, IA, Kalliokoski, OH, Call, J, Abelson, KSP, Schapiro, SJ, Gjedde, A & Hau, J 2014, 'Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid', In Vivo, bind 28, nr. 2, s. 173-84.

Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid. / Darusman, Huda S; Pandelaki, Jacub; Mulyadi, Rahmad; Sajuthi, Dondin; Putri, Indah A; Kalliokoski, Otto H; Call, Josep; Abelson, Klas S P; Schapiro, Steven J; Gjedde, Albert; Hau, Jann.

I: In Vivo, Bind 28, Nr. 2, 19.03.2014, s. 173-84.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Poor memory performance in aged cynomolgus monkeys with hippocampal atrophy, depletion of amyloid beta 1-42 and accumulation of tau proteins in cerebrospinal fluid

AU - Darusman, Huda S

AU - Pandelaki, Jacub

AU - Mulyadi, Rahmad

AU - Sajuthi, Dondin

AU - Putri, Indah A

AU - Kalliokoski, Otto H

AU - Call, Josep

AU - Abelson, Klas S P

AU - Schapiro, Steven J

AU - Gjedde, Albert

AU - Hau, Jann

PY - 2014/3/19

Y1 - 2014/3/19

N2 - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

AB - BACKGROUND: Due to their similarities in behavior and disease pathology to humans, non-human primate models are desirable to complement small animals as models for the study of age-related dementia.MATERIALS AND METHODS: Based on their performance on delayed response task (DRT) tests of memory, aged cynomolgus monkeys were divided into two groups to compare high-performing (n=6) and low-performing (n=6) subjects. Both groups were tested for biomarkers related to Alzheimer's disease and their brains were scanned using structural magnetic resonance imaging.RESULTS: The subjects with poor DRT performance had evidence of atrophy in the hippocampus and cortical areas, significantly lower cerebrospinal fluid levels of amyloid beta amino acid 1-42 (p<0.001) and higher cerebrospinal fluid total tau levels (p<0.05) compared to the group performing well on the DRT tests.CONCLUSION: Old, memory-impaired Cynomolgus monkeys may be useful as a spontaneous non-human primate model for investigations of age-related neurodegenerative diseases.

KW - Age Factors

KW - Aging

KW - Alzheimer Disease/metabolism

KW - Amyloid beta-Peptides/cerebrospinal fluid

KW - Animals

KW - Atrophy

KW - Biomarkers

KW - Disease Models, Animal

KW - Female

KW - Hippocampus/pathology

KW - Macaca fascicularis

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory

KW - tau Proteins/cerebrospinal fluid

M3 - Journal article

VL - 28

SP - 173

EP - 184

JO - In Vivo

JF - In Vivo

SN - 0258-851X

IS - 2

ER -