TY - JOUR
T1 - Plasmid Segregation: Spatial Awareness at the Molecular Level
AU - Møller-Jensen, Jakob
AU - Gerdes, Kenn
PY - 2007/11/26
Y1 - 2007/11/26
N2 - In bacteria, low-copy number plasmids ensure their stable inheritance by partition loci (par), which actively distribute plasmid replicates to each side of the cell division plane. Using time-lapse fluorescence microscopic tracking of segregating plasmid molecules, a new study provides novel insight into the workings of the par system from Escherichia coli plasmid R1. Despite its relative simplicity, the plasmid partition spindle shares characteristics with the mitotic machinery of eukaryotic cells.
AB - In bacteria, low-copy number plasmids ensure their stable inheritance by partition loci (par), which actively distribute plasmid replicates to each side of the cell division plane. Using time-lapse fluorescence microscopic tracking of segregating plasmid molecules, a new study provides novel insight into the workings of the par system from Escherichia coli plasmid R1. Despite its relative simplicity, the plasmid partition spindle shares characteristics with the mitotic machinery of eukaryotic cells.
U2 - 10.1083/jcb.200710192
DO - 10.1083/jcb.200710192
M3 - Journal article
C2 - 18039938
SN - 0021-9525
VL - 179
SP - 813
EP - 815
JO - Journal of Cell Biology
JF - Journal of Cell Biology
IS - 5
ER -