Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease

Kim Brinch, Søren Møller, Flemming Bendtsen, Ulrik Becker, Jens H. Henriksen*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background/Aims: The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. Methods: 31 patients with cirrhosis (Child classes A/B/C = 8/14/9) received an intravenous infusion of 40 g human serum albumin during a haemodynamic investigation. Results: Whereas plasma- and blood volume increased by 23 and 15%, respectively (P < 0.001), a significant increase in central blood volume was found only in class A patients (+8%, P < 0.05), but not in class B or class C patients (+2.7%, not significant (n.s.)). In contrast, arterial compliance only increased significantly in class C patients (+18%, P < 0.05), but not in class A or class B patients (+6%, n.s.). Plasma renin activity (PRA) decreased significantly in class C patients (-31%, P < 0.05). When all patients were compared, the change in arterial compliance was inversely correlated to the change in PRA (r = - 0.50, P < 0.01). Conclusions: Although infusion of albumin does not expand the central blood volume in patients with advanced cirrhosis, the results indicate a significant improvement in the low effective arterial blood volume of such patients, which may be important in the prevention of circulatory dysfunction.

OriginalsprogEngelsk
TidsskriftJournal of Hepatology
Vol/bind39
Udgave nummer1
Sider (fra-til)24-31
Antal sider8
ISSN0168-8278
DOI
StatusUdgivet - 1. jul. 2003

Fingeraftryk

Plasma Volume
Compliance
Albumins
Renin
Renin-Angiotensin System
Intravenous Infusions

Citer dette

Brinch, Kim ; Møller, Søren ; Bendtsen, Flemming ; Becker, Ulrik ; Henriksen, Jens H. / Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease. I: Journal of Hepatology. 2003 ; Bind 39, Nr. 1. s. 24-31.
@article{5bba23ea31cd430eac14e1064da0a6dd,
title = "Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease",
abstract = "Background/Aims: The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. Methods: 31 patients with cirrhosis (Child classes A/B/C = 8/14/9) received an intravenous infusion of 40 g human serum albumin during a haemodynamic investigation. Results: Whereas plasma- and blood volume increased by 23 and 15{\%}, respectively (P < 0.001), a significant increase in central blood volume was found only in class A patients (+8{\%}, P < 0.05), but not in class B or class C patients (+2.7{\%}, not significant (n.s.)). In contrast, arterial compliance only increased significantly in class C patients (+18{\%}, P < 0.05), but not in class A or class B patients (+6{\%}, n.s.). Plasma renin activity (PRA) decreased significantly in class C patients (-31{\%}, P < 0.05). When all patients were compared, the change in arterial compliance was inversely correlated to the change in PRA (r = - 0.50, P < 0.01). Conclusions: Although infusion of albumin does not expand the central blood volume in patients with advanced cirrhosis, the results indicate a significant improvement in the low effective arterial blood volume of such patients, which may be important in the prevention of circulatory dysfunction.",
keywords = "Albumin, Blood volume distribution, Central blood volume, Circulatory dysfunction, Effective arterial blood volume, Plasma volume expansion, Renin-angiotensin-aldosterone system",
author = "Kim Brinch and S{\o}ren M{\o}ller and Flemming Bendtsen and Ulrik Becker and Henriksen, {Jens H.}",
year = "2003",
month = "7",
day = "1",
doi = "10.1016/S0168-8278(03)00160-0",
language = "English",
volume = "39",
pages = "24--31",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "1",

}

Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease. / Brinch, Kim; Møller, Søren; Bendtsen, Flemming; Becker, Ulrik; Henriksen, Jens H.

I: Journal of Hepatology, Bind 39, Nr. 1, 01.07.2003, s. 24-31.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Plasma volume expansion by albumin in cirrhosis. Relation to blood volume distribution, arterial compliance and severity of disease

AU - Brinch, Kim

AU - Møller, Søren

AU - Bendtsen, Flemming

AU - Becker, Ulrik

AU - Henriksen, Jens H.

PY - 2003/7/1

Y1 - 2003/7/1

N2 - Background/Aims: The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. Methods: 31 patients with cirrhosis (Child classes A/B/C = 8/14/9) received an intravenous infusion of 40 g human serum albumin during a haemodynamic investigation. Results: Whereas plasma- and blood volume increased by 23 and 15%, respectively (P < 0.001), a significant increase in central blood volume was found only in class A patients (+8%, P < 0.05), but not in class B or class C patients (+2.7%, not significant (n.s.)). In contrast, arterial compliance only increased significantly in class C patients (+18%, P < 0.05), but not in class A or class B patients (+6%, n.s.). Plasma renin activity (PRA) decreased significantly in class C patients (-31%, P < 0.05). When all patients were compared, the change in arterial compliance was inversely correlated to the change in PRA (r = - 0.50, P < 0.01). Conclusions: Although infusion of albumin does not expand the central blood volume in patients with advanced cirrhosis, the results indicate a significant improvement in the low effective arterial blood volume of such patients, which may be important in the prevention of circulatory dysfunction.

AB - Background/Aims: The aim of the study was to investigate the effect of a standard albumin load on blood volume distribution, arterial compliance, and the renin-angiotensin-aldosterone system in patients with different degrees of cirrhosis. Methods: 31 patients with cirrhosis (Child classes A/B/C = 8/14/9) received an intravenous infusion of 40 g human serum albumin during a haemodynamic investigation. Results: Whereas plasma- and blood volume increased by 23 and 15%, respectively (P < 0.001), a significant increase in central blood volume was found only in class A patients (+8%, P < 0.05), but not in class B or class C patients (+2.7%, not significant (n.s.)). In contrast, arterial compliance only increased significantly in class C patients (+18%, P < 0.05), but not in class A or class B patients (+6%, n.s.). Plasma renin activity (PRA) decreased significantly in class C patients (-31%, P < 0.05). When all patients were compared, the change in arterial compliance was inversely correlated to the change in PRA (r = - 0.50, P < 0.01). Conclusions: Although infusion of albumin does not expand the central blood volume in patients with advanced cirrhosis, the results indicate a significant improvement in the low effective arterial blood volume of such patients, which may be important in the prevention of circulatory dysfunction.

KW - Albumin

KW - Blood volume distribution

KW - Central blood volume

KW - Circulatory dysfunction

KW - Effective arterial blood volume

KW - Plasma volume expansion

KW - Renin-angiotensin-aldosterone system

UR - http://www.scopus.com/inward/record.url?scp=0038310870&partnerID=8YFLogxK

U2 - 10.1016/S0168-8278(03)00160-0

DO - 10.1016/S0168-8278(03)00160-0

M3 - Journal article

C2 - 12821040

AN - SCOPUS:0038310870

VL - 39

SP - 24

EP - 31

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 1

ER -