@article{e8820980ec4f11dc86ef000ea68e967b,
title = "Plasma surfactant protein D levels and the relation to body mass index in a chinese population",
abstract = "Surfactant protein D (SP-D) is a member of the collectin family and is an important component of the pulmonary innate host defence. The protein has a widespread distribution in the human body and is present in multiple epithelia, in endothelium and in blood. Various studies have looked at the relationship between serum SP-D levels and pulmonary inflammatory diseases. The SP-D distribution has been most thoroughly described in European populations and appears with a broad range of serum values highly influenced by genetic factors. In the present study, we investigated the plasma SP-D distribution in a Chinese population from the Tai An region comprising 268 individuals. We found that (i) plasma SP-D in the Chinese population was distributed with a median value of 380.2 ng/ml (324.9; 418.7) and a range from 79.4 to 3965.3 ng/ml, (ii) significantly higher plasma SP-D in men than in women, and no significant effect of age, and (iii) a significant inverse association between serum SP-D and body mass index (BMI) (P = 0.012). The data indicate that racial differences in SP-D expression exist as the median plasma SP-D in the Chinese population was approximately two times lower than the median serum SP-D previously measured in a Danish population using the same immuno-assay. The inverse association between serum SP-D and BMI found in the Chinese population indicates that serum SP-D is related to obesity in similar ways in Chinese and Danes.",
keywords = "Adult, Age Factors, Asian Continental Ancestry Group, Body Mass Index, Female, Humans, Male, Middle Aged, Obesity, Pulmonary Surfactant-Associated Protein D, Sex Factors",
author = "Zhao, \{X M\} and Wu, \{Y P\} and R Wei and Cai, \{H X\} and I Tornoe and Han, \{J J\} and Y Wang and \{de Groot\}, \{P G\} and U Holmskov and Xia, \{Z L\} and S{\o}rensen, \{Grith Lykke\}",
year = "2007",
month = jul,
day = "1",
doi = "10.1111/j.1365-3083.2007.01943.x",
language = "English",
volume = "66",
pages = "71--6",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley",
number = "1",
}