Plasma proteomics to identify biomarkers - Application to cardiovascular diseases

Hans Christian Beck; Martin Overgaard; Lars Melholt Rasmussen

doi:10.1016/j.trprot.2015.01.001

Plasma proteomics to identify biomarkers - Application to cardiovascular diseases

Hans Christian Beck^*, Martin Overgaard, Lars Melholt Rasmussen

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Abstract

There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challenges and considerations, including strategies, recent discoveries and clinical applications in cardiovascular proteomics that may lead to the discovery of novel cardiovascular biomarkers.

Originalsprog	Engelsk
Tidsskrift	Translational Proteomics
Vol/bind	7
Udgave nummer	June
Sider (fra-til)	40-48
Antal sider	9
ISSN	2212-9634
DOI	https://doi.org/10.1016/j.trprot.2015.01.001
Status	Udgivet - 1. jun. 2015

Emneord

Cardiovascular disease
Plasma
Protein biomarkers
Proteomics

Dokumenter og links

10.1016/j.trprot.2015.01.001Licens: CC BY-NC-ND

Plasma proteomics to identify biomarkers – application toForlagets udgivne version, 540 KBLicens: CC BY-NC-ND

Citationsformater

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KW - Protein biomarkers

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Plasma proteomics to identify biomarkers - Application to cardiovascular diseases

Abstract

Emneord

Dokumenter og links

Fingeraftryk

Citationsformater