Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients

Line Brøndum, Jesper Grau Eriksen, Brita Singers Sørensen, Lise Saksø Mortensen, Kasper Toustrup, Jens Overgaard, Jan Alsner

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

101 Downloads (Pure)

Abstrakt

Background: Blood-based protein biomarkers can be a useful tool as pre-treatment prognostic markers, as they can reflect both variations in the tumor microenvironment and the host immune response. We investigated the influence of a panel of plasma proteins for the development of any failure defined as recurrent disease in the T-, N-, or M-site in HNSCC.

Methods: We used a multiplex bead-based approach to analyze 19 proteins in 86 HNSCC patients and 15 healthy controls. We evaluated the associations between the biomarkers, loco-regional failure, failure in the T-, N-, or M-site, overall survival (OS), p16 status, and hypoxia.

Results: In 41 p16 positive oropharynx cancer patients we identified a profile of biomarkers consisting of upregulation of IL-2, IL-4, IL-6, IL-8, eotaxin, GRO-a, and VEGF and downregulation of VEGFR-1 and VEGFR-2 with a significantly reduced risk of failure (p < 0.01). None of the individual proteins were associated with outcome.

Conclusion: The identified plasma profile potentially reflects an activated immune response in a subgroup of the p16 positive patients.

OriginalsprogEngelsk
TidsskriftClinical and Translational Radiation Oncology
Vol/bind2
Sider (fra-til)46-52
ISSN2405-6308
DOI
StatusUdgivet - 1. feb. 2017

Fingeraftryk

Dyk ned i forskningsemnerne om 'Plasma proteins as prognostic biomarkers in radiotherapy treated head and neck cancer patients'. Sammen danner de et unikt fingeraftryk.

Citationsformater