Plasma HER2 amplification in cell-free DNA during neoadjuvant chemotherapy in breast cancer

Troels Bechmann, Rikke Fredslund Andersen, Niels Pallisgaard, Jonna Skov Madsen, Else Maae, E. H. Jakobsen, Anne Marie Bak Jylling, Karina Dahl Steffensen, Anders Jakobsen

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Abstrakt

Measurement of human epidermal growth factor receptor 2 (HER2) gene amplification in cell-free DNA (cfDNA) is an evolving technique in breast cancer, enabling liquid biopsies and treatment monitoring. The present study investigated the dynamics of plasma HER2 gene copy number and amplification in cfDNA during neoadjuvant chemotherapy.
OriginalsprogEngelsk
BogserieJournal of Cancer Research and Clinical Oncology. Supplement
Vol/bind139
Udgave nummer6
Sider (fra-til)995-1003
Antal sider9
ISSN0943-9382
DOI
StatusUdgivet - jun. 2013

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