Plasma concentrations of osteoprotegerin during normo- and hyperglycaemic clamping

S T Knudsen, Peter Jeppesen, P L Poulsen, N H Andersen, T Bek, O Schmitz, C E Mogensen, Lars Melholt Rasmussen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
OriginalsprogEngelsk
TidsskriftScandinavian Journal of Clinical & Laboratory Investigation
Vol/bind67
Udgave nummer2
Sider (fra-til)135-142
Antal sider7
ISSN0036-5513
DOI
StatusUdgivet - 2007

Fingeraftryk

Osteoprotegerin
Constriction
Hyperglycemia
Cross-Over Studies
Hyperinsulinism

Citer dette

Knudsen, S T ; Jeppesen, Peter ; Poulsen, P L ; Andersen, N H ; Bek, T ; Schmitz, O ; Mogensen, C E ; Rasmussen, Lars Melholt. / Plasma concentrations of osteoprotegerin during normo- and hyperglycaemic clamping. I: Scandinavian Journal of Clinical & Laboratory Investigation. 2007 ; Bind 67, Nr. 2. s. 135-142.
@article{125a8a90cb2e11dc8674000ea68e967b,
title = "Plasma concentrations of osteoprotegerin during normo- and hyperglycaemic clamping",
abstract = "OBJECTIVE: Plasma levels of osteoprotegerin (OPG) are elevated in subjects with diabetes as well as in non-diabetic subjects with cardiovascular disease. In previous studies a positive correlation was found between plasma levels of OPG and markers of glycaemic control in diabetic subjects. The aim of the present study was to examine the effect of acute hyperglycaemia on plasma levels of OPG in non-diabetic subjects. MATERIAL AND METHODS: Nine healthy, lean, male subjects were examined in a randomized, blinded, cross-over study design during hyperglycaemic (plasma glucose = 15 mmol/L, study H) as well as during euglycaemic (plasma glucose = 5 mmol/L, study E) conditions. Blood samples were collected at baseline and at t=240 min. RESULTS: Plasma OPG decreased slightly during study H (1.26+/-0.39 versus 1.19+/-0.35 ng/mL, p<0.05), whereas the level did not change significantly during study E (1.40+/-0.46 ng/mL versus 1.57+/-0.50 ng/mL, NS). The decrease in plasma OPG during hyperglycaemia did not correlate with the change in plasma glucose but correlated significantly with changes in serum insulin (r=-0.70, p=0.038). CONCLUSIONS: Acute hyperglycaemia does not seem to increase plasma levels of OPG in non-diabetic subjects, whereas hyperinsulinaemia may suppress plasma levels of OPG. This finding indicates that the elevated plasma levels of OPG observed in diabetic subjects with poor metabolic control cannot be ascribed to hyperglycaemia per se.",
keywords = "Adult, Blood Glucose, Cross-Over Studies, Glucose Clamp Technique, Humans, Insulin, Male, Osteoprotegerin, Single-Blind Method, Somatostatin",
author = "Knudsen, {S T} and Peter Jeppesen and Poulsen, {P L} and Andersen, {N H} and T Bek and O Schmitz and Mogensen, {C E} and Rasmussen, {Lars Melholt}",
year = "2007",
doi = "10.1080/00365510600987728",
language = "English",
volume = "67",
pages = "135--142",
journal = "Scandinavian Journal of Clinical & Laboratory Investigation",
issn = "0036-5513",
publisher = "Taylor & Francis",
number = "2",

}

Plasma concentrations of osteoprotegerin during normo- and hyperglycaemic clamping. / Knudsen, S T; Jeppesen, Peter; Poulsen, P L; Andersen, N H; Bek, T; Schmitz, O; Mogensen, C E; Rasmussen, Lars Melholt.

I: Scandinavian Journal of Clinical & Laboratory Investigation, Bind 67, Nr. 2, 2007, s. 135-142.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Plasma concentrations of osteoprotegerin during normo- and hyperglycaemic clamping

AU - Knudsen, S T

AU - Jeppesen, Peter

AU - Poulsen, P L

AU - Andersen, N H

AU - Bek, T

AU - Schmitz, O

AU - Mogensen, C E

AU - Rasmussen, Lars Melholt

PY - 2007

Y1 - 2007

N2 - OBJECTIVE: Plasma levels of osteoprotegerin (OPG) are elevated in subjects with diabetes as well as in non-diabetic subjects with cardiovascular disease. In previous studies a positive correlation was found between plasma levels of OPG and markers of glycaemic control in diabetic subjects. The aim of the present study was to examine the effect of acute hyperglycaemia on plasma levels of OPG in non-diabetic subjects. MATERIAL AND METHODS: Nine healthy, lean, male subjects were examined in a randomized, blinded, cross-over study design during hyperglycaemic (plasma glucose = 15 mmol/L, study H) as well as during euglycaemic (plasma glucose = 5 mmol/L, study E) conditions. Blood samples were collected at baseline and at t=240 min. RESULTS: Plasma OPG decreased slightly during study H (1.26+/-0.39 versus 1.19+/-0.35 ng/mL, p<0.05), whereas the level did not change significantly during study E (1.40+/-0.46 ng/mL versus 1.57+/-0.50 ng/mL, NS). The decrease in plasma OPG during hyperglycaemia did not correlate with the change in plasma glucose but correlated significantly with changes in serum insulin (r=-0.70, p=0.038). CONCLUSIONS: Acute hyperglycaemia does not seem to increase plasma levels of OPG in non-diabetic subjects, whereas hyperinsulinaemia may suppress plasma levels of OPG. This finding indicates that the elevated plasma levels of OPG observed in diabetic subjects with poor metabolic control cannot be ascribed to hyperglycaemia per se.

AB - OBJECTIVE: Plasma levels of osteoprotegerin (OPG) are elevated in subjects with diabetes as well as in non-diabetic subjects with cardiovascular disease. In previous studies a positive correlation was found between plasma levels of OPG and markers of glycaemic control in diabetic subjects. The aim of the present study was to examine the effect of acute hyperglycaemia on plasma levels of OPG in non-diabetic subjects. MATERIAL AND METHODS: Nine healthy, lean, male subjects were examined in a randomized, blinded, cross-over study design during hyperglycaemic (plasma glucose = 15 mmol/L, study H) as well as during euglycaemic (plasma glucose = 5 mmol/L, study E) conditions. Blood samples were collected at baseline and at t=240 min. RESULTS: Plasma OPG decreased slightly during study H (1.26+/-0.39 versus 1.19+/-0.35 ng/mL, p<0.05), whereas the level did not change significantly during study E (1.40+/-0.46 ng/mL versus 1.57+/-0.50 ng/mL, NS). The decrease in plasma OPG during hyperglycaemia did not correlate with the change in plasma glucose but correlated significantly with changes in serum insulin (r=-0.70, p=0.038). CONCLUSIONS: Acute hyperglycaemia does not seem to increase plasma levels of OPG in non-diabetic subjects, whereas hyperinsulinaemia may suppress plasma levels of OPG. This finding indicates that the elevated plasma levels of OPG observed in diabetic subjects with poor metabolic control cannot be ascribed to hyperglycaemia per se.

KW - Adult

KW - Blood Glucose

KW - Cross-Over Studies

KW - Glucose Clamp Technique

KW - Humans

KW - Insulin

KW - Male

KW - Osteoprotegerin

KW - Single-Blind Method

KW - Somatostatin

U2 - 10.1080/00365510600987728

DO - 10.1080/00365510600987728

M3 - Journal article

VL - 67

SP - 135

EP - 142

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

SN - 0036-5513

IS - 2

ER -