Plasma CCN2 is independently related to subsequent need for abdominal aorta aneurysm repair

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstrakt

The objective of this study was to determine if plasma CCN2 is associated with abdominal aorta aneurysm (AAA), and future need for AAA repair, and further to assess the potential clinical value of CCN2 in predicting disease outcome. CCN2 was quantified in plasma samples obtained from a cohort of 679 men aged 65–74 at initial ultrasound screening for AAA in the Viborg Vascular (VIVA) screening trial. Plasma CCN2 was correlated with need for future surgical repair in the whole study population (HR = 1.457 (1.081–1.962), p =.013) and in the AAA group alone (HR = 1.431 (1.064–1.926), p =.018), yet the predictive value (CCN2 > 0 and <0 of 0.52 and 0.55, respectively) disqualified its use in clinically relevant AAA repair prediction. In conclusion, CCN2 is independently related to subsequent need for AAA repair, but has negligible predictive power for clinical use.

OriginalsprogEngelsk
TidsskriftGrowth Factors
Vol/bind37
Udgave nummer3-4
Sider (fra-til)146-152
ISSN0897-7194
DOI
StatusUdgivet - 6. sep. 2019

Fingeraftryk Dyk ned i forskningsemnerne om 'Plasma CCN2 is independently related to subsequent need for abdominal aorta aneurysm repair'. Sammen danner de et unikt fingeraftryk.

Citationsformater