PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer

Yi Neng Han, Yuan Li, Sheng Qiang Xia*, Yuan Yuan Zhang, Jun Hua Zheng, Wei Li

*Kontaktforfatter for dette arbejde

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Resumé

P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

OriginalsprogEngelsk
TidsskriftCellular Physiology and Biochemistry
Vol/bind44
Udgave nummer1
Sider (fra-til)1–20
ISSN1015-8987
DOI
StatusUdgivet - 2017

Fingeraftryk

RNA
Neoplasms
Proteins
Maintenance
Untranslated RNA
Epigenomics
Germ Cells
Small Interfering RNA

Citer dette

Han, Yi Neng ; Li, Yuan ; Xia, Sheng Qiang ; Zhang, Yuan Yuan ; Zheng, Jun Hua ; Li, Wei. / PIWI Proteins and PIWI-Interacting RNA : Emerging Roles in Cancer. I: Cellular Physiology and Biochemistry. 2017 ; Bind 44, Nr. 1. s. 1–20.
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title = "PIWI Proteins and PIWI-Interacting RNA: Emerging Roles in Cancer",
abstract = "P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.",
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author = "Han, {Yi Neng} and Yuan Li and Xia, {Sheng Qiang} and Zhang, {Yuan Yuan} and Zheng, {Jun Hua} and Wei Li",
year = "2017",
doi = "10.1159/000484541",
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PIWI Proteins and PIWI-Interacting RNA : Emerging Roles in Cancer. / Han, Yi Neng; Li, Yuan; Xia, Sheng Qiang; Zhang, Yuan Yuan; Zheng, Jun Hua; Li, Wei.

I: Cellular Physiology and Biochemistry, Bind 44, Nr. 1, 2017, s. 1–20.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - PIWI Proteins and PIWI-Interacting RNA

T2 - Emerging Roles in Cancer

AU - Han, Yi Neng

AU - Li, Yuan

AU - Xia, Sheng Qiang

AU - Zhang, Yuan Yuan

AU - Zheng, Jun Hua

AU - Li, Wei

PY - 2017

Y1 - 2017

N2 - P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

AB - P-Element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are a type of noncoding RNAs (ncRNAs) and interact with PIWI proteins. piRNAs were primarily described in the germline, but emerging evidence revealed that piRNAs are expressed in a tissue-specific manner among multiple human somatic tissue types as well and play important roles in transposon silencing, epigenetic regulation, gene and protein regulation, genome rearrangement, spermatogenesis and germ stem-cell maintenance. PIWI proteins were first discovered in Drosophila and they play roles in spermatogenesis, germline stem-cell maintenance, self-renewal, retrotransposons silencing and the male germline mobility control. A growing number of studies have demonstrated that several piRNA and PIWI proteins are aberrantly expressed in various kinds of cancers and may probably serve as a novel biomarker and therapeutic target for cancer treatment. Nevertheless, their specific mechanisms and functions need further investigation. In this review, we discuss about the biogenesis, functions and the emerging role of piRNAs and PIWI proteins in cancer, providing novel insights into the possible applications of piRNAs and PIWI proteins in cancer diagnosis and clinical treatment.

KW - Bioinformatics analysis

KW - Biomarkers

KW - Cancer

KW - piRNAs

KW - Therapy

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DO - 10.1159/000484541

M3 - Review

C2 - 29130960

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