PET/CT and Histopathologic Response to Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer

Charlotte Kristiansen, Annika Loft, Anne K Berthelsen, Jesper Graff, Jan Lindebjerg, Claus Bisgaard, Anders Jakobsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

 
Udgivelsesdato: 2008-Jan
OriginalsprogEngelsk
TidsskriftDiseases of the Colon and Rectum
Vol/bind51
Udgave nummer1
Sider (fra-til)21-25
Antal sider4
ISSN0012-3706
DOI
StatusUdgivet - 1. jan. 2008

Fingeraftryk

Rectal Neoplasms
Tegafur
Uracil
Neoplasms

Citer dette

Kristiansen, Charlotte ; Loft, Annika ; Berthelsen, Anne K ; Graff, Jesper ; Lindebjerg, Jan ; Bisgaard, Claus ; Jakobsen, Anders. / PET/CT and Histopathologic Response to Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer. I: Diseases of the Colon and Rectum. 2008 ; Bind 51, Nr. 1. s. 21-25.
@article{300e6710d3d411dcb2ba000ea68e967b,
title = "PET/CT and Histopathologic Response to Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer",
abstract = "PURPOSE: The objective of this study was to investigate the possibility of using positron emission tomography/computer tomography to predict the histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiation. METHODS: The study included 30 patients with locally advanced rectal adenocarcinoma treated with a combination of radiotherapy and concurrent Uftoral(R) (uracil, tegafur) and leucovorine. All patients were evaluated by positron emission tomography/computer tomography scan seven weeks after end of chemoradiation, and the results were compared to histopathologic tumor regression as the {"}standard.{"} The pathologic response was quantified by tumor regression grade. RESULTS: Positron emission tomography/computer tomography correctly identified six of eight patients (specificity 75 percent) with complete pathologic response. However, the sensitivity of positron emission tomography/computer tomography was only 45 percent and the accuracy 53 percent. The positive and negative predictive values were 83 and 33 percent, respectively. CONCLUSIONS: We conclude that positron emission tomography/computer tomography performed seven weeks after the end of chemoradiation is not able to predict the histopathologic response in locally advanced rectal cancer. There is an obvious need for other complementary methods especially with respect to the low sensitivity of positron emission tomography/computer tomography.",
author = "Charlotte Kristiansen and Annika Loft and Berthelsen, {Anne K} and Jesper Graff and Jan Lindebjerg and Claus Bisgaard and Anders Jakobsen",
year = "2008",
month = "1",
day = "1",
doi = "10.1007/s10350-007-9095-1",
language = "English",
volume = "51",
pages = "21--25",
journal = "Diseases of the Colon and Rectum",
issn = "0012-3706",
publisher = "Lippincott Williams & Wilkins",
number = "1",

}

PET/CT and Histopathologic Response to Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer. / Kristiansen, Charlotte; Loft, Annika; Berthelsen, Anne K; Graff, Jesper; Lindebjerg, Jan; Bisgaard, Claus; Jakobsen, Anders.

I: Diseases of the Colon and Rectum, Bind 51, Nr. 1, 01.01.2008, s. 21-25.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - PET/CT and Histopathologic Response to Preoperative Chemoradiation Therapy in Locally Advanced Rectal Cancer

AU - Kristiansen, Charlotte

AU - Loft, Annika

AU - Berthelsen, Anne K

AU - Graff, Jesper

AU - Lindebjerg, Jan

AU - Bisgaard, Claus

AU - Jakobsen, Anders

PY - 2008/1/1

Y1 - 2008/1/1

N2 - PURPOSE: The objective of this study was to investigate the possibility of using positron emission tomography/computer tomography to predict the histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiation. METHODS: The study included 30 patients with locally advanced rectal adenocarcinoma treated with a combination of radiotherapy and concurrent Uftoral(R) (uracil, tegafur) and leucovorine. All patients were evaluated by positron emission tomography/computer tomography scan seven weeks after end of chemoradiation, and the results were compared to histopathologic tumor regression as the "standard." The pathologic response was quantified by tumor regression grade. RESULTS: Positron emission tomography/computer tomography correctly identified six of eight patients (specificity 75 percent) with complete pathologic response. However, the sensitivity of positron emission tomography/computer tomography was only 45 percent and the accuracy 53 percent. The positive and negative predictive values were 83 and 33 percent, respectively. CONCLUSIONS: We conclude that positron emission tomography/computer tomography performed seven weeks after the end of chemoradiation is not able to predict the histopathologic response in locally advanced rectal cancer. There is an obvious need for other complementary methods especially with respect to the low sensitivity of positron emission tomography/computer tomography.

AB - PURPOSE: The objective of this study was to investigate the possibility of using positron emission tomography/computer tomography to predict the histopathologic response in locally advanced rectal cancer treated with preoperative chemoradiation. METHODS: The study included 30 patients with locally advanced rectal adenocarcinoma treated with a combination of radiotherapy and concurrent Uftoral(R) (uracil, tegafur) and leucovorine. All patients were evaluated by positron emission tomography/computer tomography scan seven weeks after end of chemoradiation, and the results were compared to histopathologic tumor regression as the "standard." The pathologic response was quantified by tumor regression grade. RESULTS: Positron emission tomography/computer tomography correctly identified six of eight patients (specificity 75 percent) with complete pathologic response. However, the sensitivity of positron emission tomography/computer tomography was only 45 percent and the accuracy 53 percent. The positive and negative predictive values were 83 and 33 percent, respectively. CONCLUSIONS: We conclude that positron emission tomography/computer tomography performed seven weeks after the end of chemoradiation is not able to predict the histopathologic response in locally advanced rectal cancer. There is an obvious need for other complementary methods especially with respect to the low sensitivity of positron emission tomography/computer tomography.

U2 - 10.1007/s10350-007-9095-1

DO - 10.1007/s10350-007-9095-1

M3 - Journal article

VL - 51

SP - 21

EP - 25

JO - Diseases of the Colon and Rectum

JF - Diseases of the Colon and Rectum

SN - 0012-3706

IS - 1

ER -