PET Radiopharmaceuticals for Specific Bacteria Imaging

A Systematic Review

Sveva Auletta, Michela Varani, Rika Horvat, Filippo Galli, Alberto Signore, Søren Hess

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Resumé

BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018.

METHODS: A systematic review of published studies between 2005 and 2018 was performed. A team of reviewers independently screened for eligible studies. Because of differences between studies, we pooled the data where possible, otherwise, we described separately. Quality of evidence was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) approach.

RESULTS: Eligible papers included 35 published studies. Because of the heterogeneity of animal models and bacterial strains, we classified studies in relation to the type of bacterium: Gram-positive, Gram-negative, Gram-positive and negative, others.

CONCLUSIONS: Results highlighted the availability of many promising PET radiopharmaceuticals for bacterial imaging, despite some bias related to animal selection and index test, but few have been translated to human subjects. Results showed a lack of standardized infection models and experimental settings.

OriginalsprogEngelsk
Artikelnummer197
TidsskriftJournal of Clinical Medicine
Vol/bind8
Udgave nummer2
Antal sider26
ISSN2077-0383
DOI
StatusUdgivet - 6. feb. 2019

Fingeraftryk

Radiopharmaceuticals
Isotopes
Theoretical Models

Citer dette

Auletta, Sveva ; Varani, Michela ; Horvat, Rika ; Galli, Filippo ; Signore, Alberto ; Hess, Søren. / PET Radiopharmaceuticals for Specific Bacteria Imaging : A Systematic Review. I: Journal of Clinical Medicine. 2019 ; Bind 8, Nr. 2.
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abstract = "BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018.METHODS: A systematic review of published studies between 2005 and 2018 was performed. A team of reviewers independently screened for eligible studies. Because of differences between studies, we pooled the data where possible, otherwise, we described separately. Quality of evidence was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) approach.RESULTS: Eligible papers included 35 published studies. Because of the heterogeneity of animal models and bacterial strains, we classified studies in relation to the type of bacterium: Gram-positive, Gram-negative, Gram-positive and negative, others.CONCLUSIONS: Results highlighted the availability of many promising PET radiopharmaceuticals for bacterial imaging, despite some bias related to animal selection and index test, but few have been translated to human subjects. Results showed a lack of standardized infection models and experimental settings.",
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PET Radiopharmaceuticals for Specific Bacteria Imaging : A Systematic Review. / Auletta, Sveva; Varani, Michela; Horvat, Rika; Galli, Filippo; Signore, Alberto; Hess, Søren.

I: Journal of Clinical Medicine, Bind 8, Nr. 2, 197, 06.02.2019.

Publikation: Bidrag til tidsskriftReviewForskningpeer review

TY - JOUR

T1 - PET Radiopharmaceuticals for Specific Bacteria Imaging

T2 - A Systematic Review

AU - Auletta, Sveva

AU - Varani, Michela

AU - Horvat, Rika

AU - Galli, Filippo

AU - Signore, Alberto

AU - Hess, Søren

PY - 2019/2/6

Y1 - 2019/2/6

N2 - BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018.METHODS: A systematic review of published studies between 2005 and 2018 was performed. A team of reviewers independently screened for eligible studies. Because of differences between studies, we pooled the data where possible, otherwise, we described separately. Quality of evidence was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) approach.RESULTS: Eligible papers included 35 published studies. Because of the heterogeneity of animal models and bacterial strains, we classified studies in relation to the type of bacterium: Gram-positive, Gram-negative, Gram-positive and negative, others.CONCLUSIONS: Results highlighted the availability of many promising PET radiopharmaceuticals for bacterial imaging, despite some bias related to animal selection and index test, but few have been translated to human subjects. Results showed a lack of standardized infection models and experimental settings.

AB - BACKGROUND: Bacterial infections are still one of the main factors associated with mortality worldwide. Many radiopharmaceuticals were developed for bacterial imaging, both with single photon emission computed tomography (SPECT) and positron emission tomography (PET) isotopes. This review focuses on PET radiopharmaceuticals, performing a systematic literature review of published studies between 2005 and 2018.METHODS: A systematic review of published studies between 2005 and 2018 was performed. A team of reviewers independently screened for eligible studies. Because of differences between studies, we pooled the data where possible, otherwise, we described separately. Quality of evidence was assessed by Quality Assessment of Diagnostic Accuracy Studies (QUADAS) approach.RESULTS: Eligible papers included 35 published studies. Because of the heterogeneity of animal models and bacterial strains, we classified studies in relation to the type of bacterium: Gram-positive, Gram-negative, Gram-positive and negative, others.CONCLUSIONS: Results highlighted the availability of many promising PET radiopharmaceuticals for bacterial imaging, despite some bias related to animal selection and index test, but few have been translated to human subjects. Results showed a lack of standardized infection models and experimental settings.

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