Personalized laboratory medicine

A patient-centered future approach

Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, Csilla Sipeky, Ron Van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

31 Downloads (Pure)

Resumé

In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

OriginalsprogEngelsk
TidsskriftClinical Chemistry and Laboratory Medicine
Vol/bind56
Udgave nummer12
Sider (fra-til)1981–1991
ISSN1434-6621
DOI
StatusUdgivet - 27. nov. 2018

Fingeraftryk

Precision Medicine
Medicine
Biostatistics
Cost effectiveness
Restoration
Cost-Benefit Analysis
Artificial intelligence
Decision making
Throughput
Health
Recovery
Population

Citer dette

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., ... Marc, J. (2018). Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine, 56(12), 1981–1991. https://doi.org/10.1515/cclm-2018-0181
Prodan Žitnik, Irena ; Černe, Darko ; Mancini, Irene ; Simi, Lisa ; Pazzagli, Mario ; Di Resta, Chiara ; Podgornik, Helena ; Repič Lampret, Barbka ; Trebušak Podkrajšek, Katarina ; Sipeky, Csilla ; Van Schaik, Ron ; Brandslund, Ivan ; Vermeersch, Pieter ; Schwab, Matthias ; Marc, Janja. / Personalized laboratory medicine : A patient-centered future approach. I: Clinical Chemistry and Laboratory Medicine. 2018 ; Bind 56, Nr. 12. s. 1981–1991.
@article{70ef319e45384eccb246c87a014059ff,
title = "Personalized laboratory medicine: A patient-centered future approach",
abstract = "In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of {"}omics{"} technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.",
keywords = "advanced omics technologies, diagnostic marker, genome, metabolome, molecular profiling, proteome, transcriptome, Medical Laboratory Science, Humans, Patient-Centered Care, Precision Medicine",
author = "{Prodan Žitnik}, Irena and Darko Černe and Irene Mancini and Lisa Simi and Mario Pazzagli and {Di Resta}, Chiara and Helena Podgornik and {Repič Lampret}, Barbka and {Trebušak Podkrajšek}, Katarina and Csilla Sipeky and {Van Schaik}, Ron and Ivan Brandslund and Pieter Vermeersch and Matthias Schwab and Janja Marc",
year = "2018",
month = "11",
day = "27",
doi = "10.1515/cclm-2018-0181",
language = "English",
volume = "56",
pages = "1981–1991",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walterde Gruyter GmbH",
number = "12",

}

Prodan Žitnik, I, Černe, D, Mancini, I, Simi, L, Pazzagli, M, Di Resta, C, Podgornik, H, Repič Lampret, B, Trebušak Podkrajšek, K, Sipeky, C, Van Schaik, R, Brandslund, I, Vermeersch, P, Schwab, M & Marc, J 2018, 'Personalized laboratory medicine: A patient-centered future approach', Clinical Chemistry and Laboratory Medicine, bind 56, nr. 12, s. 1981–1991. https://doi.org/10.1515/cclm-2018-0181

Personalized laboratory medicine : A patient-centered future approach. / Prodan Žitnik, Irena; Černe, Darko; Mancini, Irene; Simi, Lisa; Pazzagli, Mario; Di Resta, Chiara; Podgornik, Helena; Repič Lampret, Barbka; Trebušak Podkrajšek, Katarina; Sipeky, Csilla; Van Schaik, Ron; Brandslund, Ivan; Vermeersch, Pieter; Schwab, Matthias; Marc, Janja.

I: Clinical Chemistry and Laboratory Medicine, Bind 56, Nr. 12, 27.11.2018, s. 1981–1991.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Personalized laboratory medicine

T2 - A patient-centered future approach

AU - Prodan Žitnik, Irena

AU - Černe, Darko

AU - Mancini, Irene

AU - Simi, Lisa

AU - Pazzagli, Mario

AU - Di Resta, Chiara

AU - Podgornik, Helena

AU - Repič Lampret, Barbka

AU - Trebušak Podkrajšek, Katarina

AU - Sipeky, Csilla

AU - Van Schaik, Ron

AU - Brandslund, Ivan

AU - Vermeersch, Pieter

AU - Schwab, Matthias

AU - Marc, Janja

PY - 2018/11/27

Y1 - 2018/11/27

N2 - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

AB - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

KW - advanced omics technologies

KW - diagnostic marker

KW - genome

KW - metabolome

KW - molecular profiling

KW - proteome

KW - transcriptome

KW - Medical Laboratory Science

KW - Humans

KW - Patient-Centered Care

KW - Precision Medicine

U2 - 10.1515/cclm-2018-0181

DO - 10.1515/cclm-2018-0181

M3 - Journal article

VL - 56

SP - 1981

EP - 1991

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 12

ER -

Prodan Žitnik I, Černe D, Mancini I, Simi L, Pazzagli M, Di Resta C et al. Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine. 2018 nov 27;56(12):1981–1991. https://doi.org/10.1515/cclm-2018-0181