Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa

Bo Langhoff Hønge, Magnús Pétur Bjarnason Obinah, Sanne Jespersen, Candida Medina, David da Silva Té, Zacarias José da Silva, Lars Østergaard, Alex Lund Laursen, Christian Wejse, Christian Erikstrup, Bissau HIV Cohort Study Group, Morten Sodemann (Medlem af forfattergruppering)

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Abstrakt

As HIV-2 is intrinsically resistant to nonnucleoside reverse transcriptase inhibitors, it is mandatory to discriminate between HIV types before initiating antiretroviral treatment. Guinea-Bissau has the world's highest prevalence of HIV-2 and HIV-1/HIV-2 dually infected individuals. We evaluated 3 rapid tests for discrimination between HIV-1, HIV-2, and dual infections among 219 patients from Guinea-Bissau by comparing with the gold standard (INNO-LIA). Genie III HIV-1/HIV-2 was the best performer with regard to discriminatory capacity (agreement 91.8%), followed by Immunoflow HIV1-HIV2 (agreement 90.9%) and SD Bioline HIV-1/2 3.0 (agreement 84.5%). Our results underscore the need for evaluation of tests in relevant populations before implementation.
OriginalsprogEngelsk
TidsskriftJ A I D S
Vol/bind65
Udgave nummer1
Sider (fra-til)87-90
ISSN1525-4135
DOI
StatusUdgivet - 2014

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Citationsformater

Hønge, B. L., Bjarnason Obinah, M. P., Jespersen, S., Medina, C., Té, D. D. S., da Silva, Z. J., Østergaard, L., Laursen, A. L., Wejse, C., Erikstrup, C., Bissau HIV Cohort Study Group, & Sodemann, M. (2014). Performance of 3 rapid tests for discrimination between HIV-1 and HIV-2 in Guinea-Bissau, West Africa. J A I D S, 65(1), 87-90. https://doi.org/10.1097/QAI.0b013e3182a97b81