Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

141 Downloads (Pure)

Abstrakt

Measurements of immunoglobulins and serum free light chains (sFLC) are frequently used in patients with monoclonal plasma cell dyscrasia (PCD). For optimum patient care, well-defined performance standards or goals for the measured concentrations of immunoglobulins and sFLC are required. Generally, data based on biological variation is a good and reliable method for setting desirable performance standards; this also applies for the measurements of paraprotein and sFLC. The benefits of this approach are several. Among others, it is independent of the clinician, and it provides us with information about reference change value and index of individuality. Several studies on biological variation of both immunoglobulins and sFLC have been published, and mostly the studies are well performed. The studies normally show small within-subject biological variation resulting in strict analytical goals, which in most cases are difficult to meet. Nevertheless, we still need further information on biological variation of immunoglobulins and sFLC in patients with PCD and in the elderly, which are the main target populations for the two measurands. Furthermore, to improve data on biological variation of immunoglobulins and sFLC, studies accounting for number of individuals, samples, and replicates, as well as time length of the studies are needed.

OriginalsprogEngelsk
TidsskriftClinical Chemistry and Laboratory Medicine
Vol/bind54
Udgave nummer6
Sider (fra-til)1031–1033
ISSN1434-6621
DOI
StatusUdgivet - 1. jun. 2016

Fingeraftryk

Dyk ned i forskningsemnerne om 'Performance goals for immunoglobulins and serum free light chain measurements in plasma cell dyscrasias can be based on biological variation'. Sammen danner de et unikt fingeraftryk.

Citationsformater