Perfluoroalkyl substances and changes in bone mineral density

A prospective analysis in the POUNDS-LOST study

Yang Hu, Gang Liu, Jennifer Rood, Liming Liang, George A. Bray, Lilian de Jonge, Brent Coull, Jeremy D. Furtado, Lu Qi, Philippe Grandjean, Qi Sun*

*Kontaktforfatter for dette arbejde

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Recent studies suggested an inverse association between exposures to perfluoroalkyl substances (PFASs) and bone mineral density (BMD). Whether exposures to PFASs are also associated with changes in BMD has not been examined. Methods: Five major PFASs (perfluorooctanesulfonic acid, PFOS; perfluorooctanoic acid, PFOA; perfluorohexanesulfonic acid, PFHxS; perfluorononanoic acid, PFNA; perfluorodecanoic acid, PFDA) and BMD (g/cm2) at six bone sites (spine, total hip, femoral neck, hip intertrochanteric area, hip trochanter, and hip Ward's triangle area) were measured at baseline among 294 participants in the POUNDS-LOST study, a weight-loss trial, of whom a total of 175 participants had BMD measured at both baseline and year 2. Linear regression was used to model the differences or changes in BMD for each SD increment of PFAS concentrations. In a secondary analysis, interactions between PFASs and baseline body mass index (BMI), as well as a BMI-related genetic risk score (GRS) derived from 97 BMI-predicting SNPs were examined in relation to changes in BMD. Results: At baseline, both PFOS and PFOA were significantly associated with lower BMD at several sites. For each SD increase of PFOS, the βs (95% CIs) for BMD were −0.020(-0.037, −0.003) for spine, −0.013(-0.026, 0.001) for total hip, −0.014(-0.028, 0.000) for femoral neck, and −0.013(-0.026, 0.000) for hip trochanter. For PFOA, the corresponding figures were −0.021(-0.038, −0.004) for spine, −0.015(-0.029, −0.001) for total hip, and −0.015(-0.029, −0.002) for femoral neck. After adjusting for baseline covariates and 2-year weight change, higher baseline plasma concentrations of PFOS, PFNA, and PFDA were associated with greater reduction in BMD in the hip; the βs (95% CIs) were −0.005(-0.009, −0.001), −0.006(-0.010, −0.001), and −0.005(-0.009, −0.001), respectively. Similar associations were found in hip intertrochanteric area for all PFASs except PFHxS, with βs ranging from −0.006 for PFOA to −0.008 for PFOS and PFNA. Participants with a higher GRS tended to have less PFAS-related BMD decline in total hip (Pinteraction = 0.005) and the hip intertrochanteric area (Pinteraction = 0.021). There were similar PFAS-related BMD changes by baseline BMI levels, although the interactions did not achieve statistical significance. Conclusions: This study demonstrated that higher plasma PFAS concentrations were not only associated with a lower BMD at baseline, but also a faster BMD loss in a weight-loss trial setting. Genetic predisposition to larger body size may somewhat attenuate the deleterious effects of PFASs on BMD. Further exploration of the possible impact of PFAS exposures on bone density is warranted.

OriginalsprogEngelsk
Artikelnummer108775
TidsskriftEnvironmental Research
Vol/bind179
Antal sider7
ISSN0013-9351
DOI
StatusUdgivet - 2019

Fingeraftryk

Bone Density
Minerals
bone
Bone
Hip
mineral
body mass
Femur Neck
Body Mass Index
acid
perfluorooctanoic acid
analysis
Plasmas
plasma
Linear regression
Single Nucleotide Polymorphism
Linear Models
body size

Citer dette

Hu, Yang ; Liu, Gang ; Rood, Jennifer ; Liang, Liming ; Bray, George A. ; de Jonge, Lilian ; Coull, Brent ; Furtado, Jeremy D. ; Qi, Lu ; Grandjean, Philippe ; Sun, Qi. / Perfluoroalkyl substances and changes in bone mineral density : A prospective analysis in the POUNDS-LOST study. I: Environmental Research. 2019 ; Bind 179.
@article{89fb15efee2c49a3a26cd68c1687b7b3,
title = "Perfluoroalkyl substances and changes in bone mineral density: A prospective analysis in the POUNDS-LOST study",
abstract = "Background: Recent studies suggested an inverse association between exposures to perfluoroalkyl substances (PFASs) and bone mineral density (BMD). Whether exposures to PFASs are also associated with changes in BMD has not been examined. Methods: Five major PFASs (perfluorooctanesulfonic acid, PFOS; perfluorooctanoic acid, PFOA; perfluorohexanesulfonic acid, PFHxS; perfluorononanoic acid, PFNA; perfluorodecanoic acid, PFDA) and BMD (g/cm2) at six bone sites (spine, total hip, femoral neck, hip intertrochanteric area, hip trochanter, and hip Ward's triangle area) were measured at baseline among 294 participants in the POUNDS-LOST study, a weight-loss trial, of whom a total of 175 participants had BMD measured at both baseline and year 2. Linear regression was used to model the differences or changes in BMD for each SD increment of PFAS concentrations. In a secondary analysis, interactions between PFASs and baseline body mass index (BMI), as well as a BMI-related genetic risk score (GRS) derived from 97 BMI-predicting SNPs were examined in relation to changes in BMD. Results: At baseline, both PFOS and PFOA were significantly associated with lower BMD at several sites. For each SD increase of PFOS, the βs (95{\%} CIs) for BMD were −0.020(-0.037, −0.003) for spine, −0.013(-0.026, 0.001) for total hip, −0.014(-0.028, 0.000) for femoral neck, and −0.013(-0.026, 0.000) for hip trochanter. For PFOA, the corresponding figures were −0.021(-0.038, −0.004) for spine, −0.015(-0.029, −0.001) for total hip, and −0.015(-0.029, −0.002) for femoral neck. After adjusting for baseline covariates and 2-year weight change, higher baseline plasma concentrations of PFOS, PFNA, and PFDA were associated with greater reduction in BMD in the hip; the βs (95{\%} CIs) were −0.005(-0.009, −0.001), −0.006(-0.010, −0.001), and −0.005(-0.009, −0.001), respectively. Similar associations were found in hip intertrochanteric area for all PFASs except PFHxS, with βs ranging from −0.006 for PFOA to −0.008 for PFOS and PFNA. Participants with a higher GRS tended to have less PFAS-related BMD decline in total hip (Pinteraction = 0.005) and the hip intertrochanteric area (Pinteraction = 0.021). There were similar PFAS-related BMD changes by baseline BMI levels, although the interactions did not achieve statistical significance. Conclusions: This study demonstrated that higher plasma PFAS concentrations were not only associated with a lower BMD at baseline, but also a faster BMD loss in a weight-loss trial setting. Genetic predisposition to larger body size may somewhat attenuate the deleterious effects of PFASs on BMD. Further exploration of the possible impact of PFAS exposures on bone density is warranted.",
keywords = "Bone mineral density, Perfluoroalkyl substances, Weight-loss trial",
author = "Yang Hu and Gang Liu and Jennifer Rood and Liming Liang and Bray, {George A.} and {de Jonge}, Lilian and Brent Coull and Furtado, {Jeremy D.} and Lu Qi and Philippe Grandjean and Qi Sun",
year = "2019",
doi = "10.1016/j.envres.2019.108775",
language = "English",
volume = "179",
journal = "Environmental Research",
issn = "0013-9351",
publisher = "Heinemann",

}

Perfluoroalkyl substances and changes in bone mineral density : A prospective analysis in the POUNDS-LOST study. / Hu, Yang; Liu, Gang; Rood, Jennifer; Liang, Liming; Bray, George A.; de Jonge, Lilian; Coull, Brent; Furtado, Jeremy D.; Qi, Lu; Grandjean, Philippe; Sun, Qi.

I: Environmental Research, Bind 179, 108775, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Perfluoroalkyl substances and changes in bone mineral density

T2 - A prospective analysis in the POUNDS-LOST study

AU - Hu, Yang

AU - Liu, Gang

AU - Rood, Jennifer

AU - Liang, Liming

AU - Bray, George A.

AU - de Jonge, Lilian

AU - Coull, Brent

AU - Furtado, Jeremy D.

AU - Qi, Lu

AU - Grandjean, Philippe

AU - Sun, Qi

PY - 2019

Y1 - 2019

N2 - Background: Recent studies suggested an inverse association between exposures to perfluoroalkyl substances (PFASs) and bone mineral density (BMD). Whether exposures to PFASs are also associated with changes in BMD has not been examined. Methods: Five major PFASs (perfluorooctanesulfonic acid, PFOS; perfluorooctanoic acid, PFOA; perfluorohexanesulfonic acid, PFHxS; perfluorononanoic acid, PFNA; perfluorodecanoic acid, PFDA) and BMD (g/cm2) at six bone sites (spine, total hip, femoral neck, hip intertrochanteric area, hip trochanter, and hip Ward's triangle area) were measured at baseline among 294 participants in the POUNDS-LOST study, a weight-loss trial, of whom a total of 175 participants had BMD measured at both baseline and year 2. Linear regression was used to model the differences or changes in BMD for each SD increment of PFAS concentrations. In a secondary analysis, interactions between PFASs and baseline body mass index (BMI), as well as a BMI-related genetic risk score (GRS) derived from 97 BMI-predicting SNPs were examined in relation to changes in BMD. Results: At baseline, both PFOS and PFOA were significantly associated with lower BMD at several sites. For each SD increase of PFOS, the βs (95% CIs) for BMD were −0.020(-0.037, −0.003) for spine, −0.013(-0.026, 0.001) for total hip, −0.014(-0.028, 0.000) for femoral neck, and −0.013(-0.026, 0.000) for hip trochanter. For PFOA, the corresponding figures were −0.021(-0.038, −0.004) for spine, −0.015(-0.029, −0.001) for total hip, and −0.015(-0.029, −0.002) for femoral neck. After adjusting for baseline covariates and 2-year weight change, higher baseline plasma concentrations of PFOS, PFNA, and PFDA were associated with greater reduction in BMD in the hip; the βs (95% CIs) were −0.005(-0.009, −0.001), −0.006(-0.010, −0.001), and −0.005(-0.009, −0.001), respectively. Similar associations were found in hip intertrochanteric area for all PFASs except PFHxS, with βs ranging from −0.006 for PFOA to −0.008 for PFOS and PFNA. Participants with a higher GRS tended to have less PFAS-related BMD decline in total hip (Pinteraction = 0.005) and the hip intertrochanteric area (Pinteraction = 0.021). There were similar PFAS-related BMD changes by baseline BMI levels, although the interactions did not achieve statistical significance. Conclusions: This study demonstrated that higher plasma PFAS concentrations were not only associated with a lower BMD at baseline, but also a faster BMD loss in a weight-loss trial setting. Genetic predisposition to larger body size may somewhat attenuate the deleterious effects of PFASs on BMD. Further exploration of the possible impact of PFAS exposures on bone density is warranted.

AB - Background: Recent studies suggested an inverse association between exposures to perfluoroalkyl substances (PFASs) and bone mineral density (BMD). Whether exposures to PFASs are also associated with changes in BMD has not been examined. Methods: Five major PFASs (perfluorooctanesulfonic acid, PFOS; perfluorooctanoic acid, PFOA; perfluorohexanesulfonic acid, PFHxS; perfluorononanoic acid, PFNA; perfluorodecanoic acid, PFDA) and BMD (g/cm2) at six bone sites (spine, total hip, femoral neck, hip intertrochanteric area, hip trochanter, and hip Ward's triangle area) were measured at baseline among 294 participants in the POUNDS-LOST study, a weight-loss trial, of whom a total of 175 participants had BMD measured at both baseline and year 2. Linear regression was used to model the differences or changes in BMD for each SD increment of PFAS concentrations. In a secondary analysis, interactions between PFASs and baseline body mass index (BMI), as well as a BMI-related genetic risk score (GRS) derived from 97 BMI-predicting SNPs were examined in relation to changes in BMD. Results: At baseline, both PFOS and PFOA were significantly associated with lower BMD at several sites. For each SD increase of PFOS, the βs (95% CIs) for BMD were −0.020(-0.037, −0.003) for spine, −0.013(-0.026, 0.001) for total hip, −0.014(-0.028, 0.000) for femoral neck, and −0.013(-0.026, 0.000) for hip trochanter. For PFOA, the corresponding figures were −0.021(-0.038, −0.004) for spine, −0.015(-0.029, −0.001) for total hip, and −0.015(-0.029, −0.002) for femoral neck. After adjusting for baseline covariates and 2-year weight change, higher baseline plasma concentrations of PFOS, PFNA, and PFDA were associated with greater reduction in BMD in the hip; the βs (95% CIs) were −0.005(-0.009, −0.001), −0.006(-0.010, −0.001), and −0.005(-0.009, −0.001), respectively. Similar associations were found in hip intertrochanteric area for all PFASs except PFHxS, with βs ranging from −0.006 for PFOA to −0.008 for PFOS and PFNA. Participants with a higher GRS tended to have less PFAS-related BMD decline in total hip (Pinteraction = 0.005) and the hip intertrochanteric area (Pinteraction = 0.021). There were similar PFAS-related BMD changes by baseline BMI levels, although the interactions did not achieve statistical significance. Conclusions: This study demonstrated that higher plasma PFAS concentrations were not only associated with a lower BMD at baseline, but also a faster BMD loss in a weight-loss trial setting. Genetic predisposition to larger body size may somewhat attenuate the deleterious effects of PFASs on BMD. Further exploration of the possible impact of PFAS exposures on bone density is warranted.

KW - Bone mineral density

KW - Perfluoroalkyl substances

KW - Weight-loss trial

U2 - 10.1016/j.envres.2019.108775

DO - 10.1016/j.envres.2019.108775

M3 - Journal article

VL - 179

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

M1 - 108775

ER -