Perfluoroalkyl acids and time to pregnancy revisited

An update from the Danish National Birth Cohort

Cathrine Carlsen Bach, Zeyan Liew, Bodil Hammer Bech, Ellen Aagaard Nohr, Chunyuan Fei, Eva Cecilie Bonefeld-Jorgensen, Tine Brink Henriksen, Jørn Olsen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

62 Downloads (Pure)

Resumé

BACKGROUND: We previously demonstrated an association between plasma perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and longer time to pregnancy (TTP) in a sample from the Danish National Birth Cohort (DNBC, 1996-2002). In this study we investigated this association in a new sample from the same cohort.

METHODS: Sample 1 consisted of 440 women, and Sample 2 consisted of 1161 women from whom we previously published the associations between PFOS or PFOA and TTP. We performed sample-specific and pooled analyses using discrete-time survival analyses to estimate fecundability ratios according to PFOS and PFOA quartiles, adjusted for potential confounders chosen guided by a directed acyclic graph. We also estimated odds ratios for infertility (TTP > 12 months or infertility treatment) according to PFOS and PFOA by multivariable logistic regression.

RESULTS: In Sample 1 PFOS was not associated with lower fecundability ratios or infertility, and there was a tendency towards longer TTP with increasing PFOA only in parous women. In Sample 2 previously reported associations were again seen. In the pooled analyses including both parous and nulliparous women fecundability ratios were 13-22 % lower for the three higher quartiles of PFOS or PFOA compared to the reference quartile.

CONCLUSIONS: The pooled analyses were driven by the larger old sample, but we did not corroborate our previous finding of an association between high PFOS and longer TTP in the new sample. The tendency towards an association for PFOA and TTP in parous women may be due to reverse causation. Results from the new sample are more in line with the recent literature.

OriginalsprogEngelsk
TidsskriftEnvironmental Health: A Global Access Science Source
Vol/bind14
Sider (fra-til)59
ISSN1476-069X
DOI
StatusUdgivet - 2015

Fingeraftryk

perfluorooctanoic acid
Acids
Infertility
Survival Analysis
perfluorooctane sulfonic acid
Causality

Citer dette

Bach, Cathrine Carlsen ; Liew, Zeyan ; Bech, Bodil Hammer ; Nohr, Ellen Aagaard ; Fei, Chunyuan ; Bonefeld-Jorgensen, Eva Cecilie ; Henriksen, Tine Brink ; Olsen, Jørn. / Perfluoroalkyl acids and time to pregnancy revisited : An update from the Danish National Birth Cohort. I: Environmental Health: A Global Access Science Source. 2015 ; Bind 14. s. 59.
@article{8c06c45904444bed935baf10fb548710,
title = "Perfluoroalkyl acids and time to pregnancy revisited: An update from the Danish National Birth Cohort",
abstract = "BACKGROUND: We previously demonstrated an association between plasma perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and longer time to pregnancy (TTP) in a sample from the Danish National Birth Cohort (DNBC, 1996-2002). In this study we investigated this association in a new sample from the same cohort.METHODS: Sample 1 consisted of 440 women, and Sample 2 consisted of 1161 women from whom we previously published the associations between PFOS or PFOA and TTP. We performed sample-specific and pooled analyses using discrete-time survival analyses to estimate fecundability ratios according to PFOS and PFOA quartiles, adjusted for potential confounders chosen guided by a directed acyclic graph. We also estimated odds ratios for infertility (TTP > 12 months or infertility treatment) according to PFOS and PFOA by multivariable logistic regression.RESULTS: In Sample 1 PFOS was not associated with lower fecundability ratios or infertility, and there was a tendency towards longer TTP with increasing PFOA only in parous women. In Sample 2 previously reported associations were again seen. In the pooled analyses including both parous and nulliparous women fecundability ratios were 13-22 {\%} lower for the three higher quartiles of PFOS or PFOA compared to the reference quartile.CONCLUSIONS: The pooled analyses were driven by the larger old sample, but we did not corroborate our previous finding of an association between high PFOS and longer TTP in the new sample. The tendency towards an association for PFOA and TTP in parous women may be due to reverse causation. Results from the new sample are more in line with the recent literature.",
author = "Bach, {Cathrine Carlsen} and Zeyan Liew and Bech, {Bodil Hammer} and Nohr, {Ellen Aagaard} and Chunyuan Fei and Bonefeld-Jorgensen, {Eva Cecilie} and Henriksen, {Tine Brink} and J{\o}rn Olsen",
year = "2015",
doi = "10.1186/s12940-015-0040-9",
language = "English",
volume = "14",
pages = "59",
journal = "Environmental Health: A Global Access Science Source",
issn = "1476-069X",
publisher = "BioMed Central",

}

Perfluoroalkyl acids and time to pregnancy revisited : An update from the Danish National Birth Cohort. / Bach, Cathrine Carlsen; Liew, Zeyan; Bech, Bodil Hammer; Nohr, Ellen Aagaard; Fei, Chunyuan; Bonefeld-Jorgensen, Eva Cecilie; Henriksen, Tine Brink; Olsen, Jørn.

I: Environmental Health: A Global Access Science Source, Bind 14, 2015, s. 59.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Perfluoroalkyl acids and time to pregnancy revisited

T2 - An update from the Danish National Birth Cohort

AU - Bach, Cathrine Carlsen

AU - Liew, Zeyan

AU - Bech, Bodil Hammer

AU - Nohr, Ellen Aagaard

AU - Fei, Chunyuan

AU - Bonefeld-Jorgensen, Eva Cecilie

AU - Henriksen, Tine Brink

AU - Olsen, Jørn

PY - 2015

Y1 - 2015

N2 - BACKGROUND: We previously demonstrated an association between plasma perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and longer time to pregnancy (TTP) in a sample from the Danish National Birth Cohort (DNBC, 1996-2002). In this study we investigated this association in a new sample from the same cohort.METHODS: Sample 1 consisted of 440 women, and Sample 2 consisted of 1161 women from whom we previously published the associations between PFOS or PFOA and TTP. We performed sample-specific and pooled analyses using discrete-time survival analyses to estimate fecundability ratios according to PFOS and PFOA quartiles, adjusted for potential confounders chosen guided by a directed acyclic graph. We also estimated odds ratios for infertility (TTP > 12 months or infertility treatment) according to PFOS and PFOA by multivariable logistic regression.RESULTS: In Sample 1 PFOS was not associated with lower fecundability ratios or infertility, and there was a tendency towards longer TTP with increasing PFOA only in parous women. In Sample 2 previously reported associations were again seen. In the pooled analyses including both parous and nulliparous women fecundability ratios were 13-22 % lower for the three higher quartiles of PFOS or PFOA compared to the reference quartile.CONCLUSIONS: The pooled analyses were driven by the larger old sample, but we did not corroborate our previous finding of an association between high PFOS and longer TTP in the new sample. The tendency towards an association for PFOA and TTP in parous women may be due to reverse causation. Results from the new sample are more in line with the recent literature.

AB - BACKGROUND: We previously demonstrated an association between plasma perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and longer time to pregnancy (TTP) in a sample from the Danish National Birth Cohort (DNBC, 1996-2002). In this study we investigated this association in a new sample from the same cohort.METHODS: Sample 1 consisted of 440 women, and Sample 2 consisted of 1161 women from whom we previously published the associations between PFOS or PFOA and TTP. We performed sample-specific and pooled analyses using discrete-time survival analyses to estimate fecundability ratios according to PFOS and PFOA quartiles, adjusted for potential confounders chosen guided by a directed acyclic graph. We also estimated odds ratios for infertility (TTP > 12 months or infertility treatment) according to PFOS and PFOA by multivariable logistic regression.RESULTS: In Sample 1 PFOS was not associated with lower fecundability ratios or infertility, and there was a tendency towards longer TTP with increasing PFOA only in parous women. In Sample 2 previously reported associations were again seen. In the pooled analyses including both parous and nulliparous women fecundability ratios were 13-22 % lower for the three higher quartiles of PFOS or PFOA compared to the reference quartile.CONCLUSIONS: The pooled analyses were driven by the larger old sample, but we did not corroborate our previous finding of an association between high PFOS and longer TTP in the new sample. The tendency towards an association for PFOA and TTP in parous women may be due to reverse causation. Results from the new sample are more in line with the recent literature.

U2 - 10.1186/s12940-015-0040-9

DO - 10.1186/s12940-015-0040-9

M3 - Journal article

VL - 14

SP - 59

JO - Environmental Health: A Global Access Science Source

JF - Environmental Health: A Global Access Science Source

SN - 1476-069X

ER -