Perfluorinated substances, risk factors for multiple sclerosis and cellular immune activation

Cecilie Ammitzbøll*, Lars Börnsen, Eva Rosa Petersen, Annette Bang Oturai, Helle Bach Søndergaard, Philippe Grandjean, Finn Sellebjerg

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Abstrakt

Perfluorinated alkylated substances (PFASs) have immunomodulatory effects but the impact on multiple sclerosis (MS) and cellular immune functions is only sparsely described. In the present study, we found lower concentrations of the long chain PFAS perfluorooctane sulfonic acid (PFOS) in MS than in healthy controls (HC). In HC, we did not detect associations between PFOS concentrations and immune phenotypes. Analyzing the impact of known MS risk factors on cellular immune functions, we found that smoking and Epstein-Barr nuclear antigen 1 antibodies were associated with distinct circulating immune cell changes. In summary, current background PFAS exposure is not an important risk factor for MS.

OriginalsprogEngelsk
TidsskriftJournal of Neuroimmunology
Vol/bind330
Sider (fra-til)90-95
ISSN0165-5728
DOI
StatusUdgivet - 15. maj 2019

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Copyright © 2019 Elsevier B.V. All rights reserved.

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