Pediatric Inflammatory Bowel Diseases: Should We Be Looking for Kidney Abnormalities?

Didde Lauritzen, Bente Utoft Andreassen, Niels Henrik H Heegaard, Lone Gabriels Klinge, Anne-Mette Walsted, Mette Neland, Rasmus Gaardskær Nielsen, Per Wittenhagen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Background: Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment.

Methods: In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood and urine samples were analyzed for markers of kidney disease and ultrasonography was performed to evaluate pole-to-pole kidney length.

Results: We found that 25% of the patients had either previously reported kidney disease or ultrasonographic signs of chronic kidney disease. The median kidney size compared with normal children was significantly reduced. In a multivariate linear mixed model, small kidneys significantly correlated with the use of infliximab, whereas the use of enteral nutritional therapy was associated with larger kidneys.

Conclusion : Children with IBD are at risk of chronic kidney disease, and the risk seems to be increased with the severity of the disease.

OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind24
Udgave nummer12
Sider (fra-til)2599–2605
ISSN1078-0998
DOI
StatusUdgivet - 2018

Fingeraftryk

Inflammatory Bowel Diseases
Pediatrics
Kidney
Kidney Diseases
Small Intestine
Linear Models
Ultrasonography
Cross-Sectional Studies
Urine
Pathology

Citer dette

Lauritzen, D., Andreassen, B. U., Heegaard, N. H. H., Klinge, L. G., Walsted, A-M., Neland, M., ... Wittenhagen, P. (2018). Pediatric Inflammatory Bowel Diseases: Should We Be Looking for Kidney Abnormalities? Inflammatory Bowel Diseases, 24(12), 2599–2605. https://doi.org/10.1093/ibd/izy166
Lauritzen, Didde ; Andreassen, Bente Utoft ; Heegaard, Niels Henrik H ; Klinge, Lone Gabriels ; Walsted, Anne-Mette ; Neland, Mette ; Nielsen, Rasmus Gaardskær ; Wittenhagen, Per. / Pediatric Inflammatory Bowel Diseases : Should We Be Looking for Kidney Abnormalities?. I: Inflammatory Bowel Diseases. 2018 ; Bind 24, Nr. 12. s. 2599–2605.
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abstract = "Background: Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment.Methods: In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood and urine samples were analyzed for markers of kidney disease and ultrasonography was performed to evaluate pole-to-pole kidney length.Results: We found that 25{\%} of the patients had either previously reported kidney disease or ultrasonographic signs of chronic kidney disease. The median kidney size compared with normal children was significantly reduced. In a multivariate linear mixed model, small kidneys significantly correlated with the use of infliximab, whereas the use of enteral nutritional therapy was associated with larger kidneys.Conclusion : Children with IBD are at risk of chronic kidney disease, and the risk seems to be increased with the severity of the disease.",
author = "Didde Lauritzen and Andreassen, {Bente Utoft} and Heegaard, {Niels Henrik H} and Klinge, {Lone Gabriels} and Anne-Mette Walsted and Mette Neland and Nielsen, {Rasmus Gaardsk{\ae}r} and Per Wittenhagen",
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Lauritzen, D, Andreassen, BU, Heegaard, NHH, Klinge, LG, Walsted, A-M, Neland, M, Nielsen, RG & Wittenhagen, P 2018, 'Pediatric Inflammatory Bowel Diseases: Should We Be Looking for Kidney Abnormalities?', Inflammatory Bowel Diseases, bind 24, nr. 12, s. 2599–2605. https://doi.org/10.1093/ibd/izy166

Pediatric Inflammatory Bowel Diseases : Should We Be Looking for Kidney Abnormalities? / Lauritzen, Didde; Andreassen, Bente Utoft; Heegaard, Niels Henrik H; Klinge, Lone Gabriels; Walsted, Anne-Mette; Neland, Mette; Nielsen, Rasmus Gaardskær; Wittenhagen, Per.

I: Inflammatory Bowel Diseases, Bind 24, Nr. 12, 2018, s. 2599–2605.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Pediatric Inflammatory Bowel Diseases

T2 - Should We Be Looking for Kidney Abnormalities?

AU - Lauritzen, Didde

AU - Andreassen, Bente Utoft

AU - Heegaard, Niels Henrik H

AU - Klinge, Lone Gabriels

AU - Walsted, Anne-Mette

AU - Neland, Mette

AU - Nielsen, Rasmus Gaardskær

AU - Wittenhagen, Per

PY - 2018

Y1 - 2018

N2 - Background: Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment.Methods: In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood and urine samples were analyzed for markers of kidney disease and ultrasonography was performed to evaluate pole-to-pole kidney length.Results: We found that 25% of the patients had either previously reported kidney disease or ultrasonographic signs of chronic kidney disease. The median kidney size compared with normal children was significantly reduced. In a multivariate linear mixed model, small kidneys significantly correlated with the use of infliximab, whereas the use of enteral nutritional therapy was associated with larger kidneys.Conclusion : Children with IBD are at risk of chronic kidney disease, and the risk seems to be increased with the severity of the disease.

AB - Background: Kidney disease has been reported in adults with inflammatory bowel disease (IBD) and is regarded an extraintestinal manifestation or more rarely a side effect of the medical treatment.Methods: In this cross-sectional study we describe the extent of kidney pathology in a cohort of 56 children with IBD. Blood and urine samples were analyzed for markers of kidney disease and ultrasonography was performed to evaluate pole-to-pole kidney length.Results: We found that 25% of the patients had either previously reported kidney disease or ultrasonographic signs of chronic kidney disease. The median kidney size compared with normal children was significantly reduced. In a multivariate linear mixed model, small kidneys significantly correlated with the use of infliximab, whereas the use of enteral nutritional therapy was associated with larger kidneys.Conclusion : Children with IBD are at risk of chronic kidney disease, and the risk seems to be increased with the severity of the disease.

U2 - 10.1093/ibd/izy166

DO - 10.1093/ibd/izy166

M3 - Journal article

C2 - 29718370

VL - 24

SP - 2599

EP - 2605

JO - Inflammatory Bowel Diseases

JF - Inflammatory Bowel Diseases

SN - 1078-0998

IS - 12

ER -