Patterns of use of antimuscarinic drugs to treat overactive bladder in Denmark, Sweden, and the United Kingdom

Andrea V. Margulis*, Marie Linder, Alejandro Arana, Anton Pottegård, Ina Anveden Berglind, Christine L. Bui, Nina Sahlertz Kristiansen, Shahram Bahmanyar, Lisa J. McQuay, Willem Jan Atsma, Kwame Appenteng, Milbhor D'Silva, Susana Perez-Gutthann, Jesper Hallas

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    Purpose To describe the use of antimuscarinic drugs to treat overactive bladder (OAB) in Denmark, Sweden, and the United Kingdom (UK). Methods We identified new users of darifenacin, fesoterodine, oxybutynin, solifenacin, tolterodine, and trospium aged 18 years or older from the Danish National Registers (2004±2012), the Swedish National Registers (2006±2012), and UK Clinical Practice Research Datalink (2004±2012). Users were followed until disenrollment, cancer diagnosis, death, or study end. Treatment episodes, identified by linking consecutive prescriptions, were described with respect to duration, drug switch, and drug add-on. Results Mean age of OAB drug users was 66 years in Denmark (n = 72,917) and Sweden (n = 130,944), and 62 years in the UK (n = 119,912); 60% of Danish and Swedish patients and 70% of UK patients were female. In Denmark, of 224,680 treatment episodes, 39% were with solifenacin, and 35% with tolterodine; 2% were with oxybutynin. In Sweden, of 240,141 therapy episodes, 37% were with tolterodine and 35% with solifenacin; 5% were with oxybutynin. In the UK, of 245,800 treatment episodes, 28% were with oxybutynin, 27% with solifenacin, and 26% with tolterodine. In the three countries, 49%-52% of treatment episodes comprised one prescription and over 80% of episodes ended because of no refill; less than 20% ended because of a switch to another antimuscarinic. During the study years, we observed a change in OAB treatment preference from tolterodine to solifenacin. Conclusions In these cohorts, persistence with antimuscarinic drugs was low. By 2012, the preferred drug was solifenacin; oxybutynin use was marginal in Nordic countries compared with the UK.

    OriginalsprogEngelsk
    Artikelnummere0204456
    TidsskriftPLOS ONE
    Vol/bind13
    Udgave nummer9
    Antal sider13
    ISSN1932-6203
    DOI
    StatusUdgivet - 1. sep. 2018

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