Patients with ovarian cancer have elevated (51)Cr-EDTA plasma clearance early post-operatively

S S Nielsen, H Havsteen, L K Petersen, L E Nielsen, M Rehling

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Resumé

Plasma clearance of (51)Cr-EDTA (Clp(EDTA)) is widely used to determine glomerular filtration rate prior to carboplatin based chemotherapy. We have observed that many patients with ovarian cancer have elevated Clp in the early post-operative phase compared to later phases. The purpose of this study was to examine whether this observation reflects a systematic difference. We retrospectively analysed data from 53 patients who had undergone surgery for ovarian cancer. Twenty-six patients had Clp(EDTA) measured early after the operation (mean, 8 days (range, 3-16 days)) (early group), and 27 patients had Clp(EDTA) measured late post-operatively (mean, 32 days (range, 19-48 days)) (late group). Clp(EDTA) values was measured before the first, third and fifth course of chemotherapy. Additionally, age, height, weight, cancer stage, ascites and tumour histology were noted. Mean Clp(EDTA) in the early group was significantly higher than in the late group (104+/-4.4 vs 89+/-3.5 ml.min(-1) per 1.73 m(2); P =0.005). Clp(EDTA) declined significantly in the early group from the first measurement after the operation until measurement before the third course of chemotherapy but remained constant in the late group. Clp(EDTA) was not correlated to ascites, cancer stage or tumour histology. It is concluded that patients with ovarian cancer have significantly higher Clp(EDTA) in the early post-operative phase than similar patients with Clp(EDTA) measured late post-operatively.

OriginalsprogEngelsk
TidsskriftNuclear Medicine Communications
Vol/bind23
Udgave nummer9
Sider (fra-til)917-20
Antal sider4
ISSN0143-3636
StatusUdgivet - sep. 2002

Fingeraftryk

Edetic Acid
Ovarian Neoplasms
Neoplasms
Carboplatin
Glomerular Filtration Rate
Weights and Measures

Citer dette

Nielsen, S S ; Havsteen, H ; Petersen, L K ; Nielsen, L E ; Rehling, M. / Patients with ovarian cancer have elevated (51)Cr-EDTA plasma clearance early post-operatively. I: Nuclear Medicine Communications. 2002 ; Bind 23, Nr. 9. s. 917-20.
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title = "Patients with ovarian cancer have elevated (51)Cr-EDTA plasma clearance early post-operatively",
abstract = "Plasma clearance of (51)Cr-EDTA (Clp(EDTA)) is widely used to determine glomerular filtration rate prior to carboplatin based chemotherapy. We have observed that many patients with ovarian cancer have elevated Clp in the early post-operative phase compared to later phases. The purpose of this study was to examine whether this observation reflects a systematic difference. We retrospectively analysed data from 53 patients who had undergone surgery for ovarian cancer. Twenty-six patients had Clp(EDTA) measured early after the operation (mean, 8 days (range, 3-16 days)) (early group), and 27 patients had Clp(EDTA) measured late post-operatively (mean, 32 days (range, 19-48 days)) (late group). Clp(EDTA) values was measured before the first, third and fifth course of chemotherapy. Additionally, age, height, weight, cancer stage, ascites and tumour histology were noted. Mean Clp(EDTA) in the early group was significantly higher than in the late group (104+/-4.4 vs 89+/-3.5 ml.min(-1) per 1.73 m(2); P =0.005). Clp(EDTA) declined significantly in the early group from the first measurement after the operation until measurement before the third course of chemotherapy but remained constant in the late group. Clp(EDTA) was not correlated to ascites, cancer stage or tumour histology. It is concluded that patients with ovarian cancer have significantly higher Clp(EDTA) in the early post-operative phase than similar patients with Clp(EDTA) measured late post-operatively.",
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Patients with ovarian cancer have elevated (51)Cr-EDTA plasma clearance early post-operatively. / Nielsen, S S; Havsteen, H; Petersen, L K; Nielsen, L E; Rehling, M.

I: Nuclear Medicine Communications, Bind 23, Nr. 9, 09.2002, s. 917-20.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

TY - JOUR

T1 - Patients with ovarian cancer have elevated (51)Cr-EDTA plasma clearance early post-operatively

AU - Nielsen, S S

AU - Havsteen, H

AU - Petersen, L K

AU - Nielsen, L E

AU - Rehling, M

PY - 2002/9

Y1 - 2002/9

N2 - Plasma clearance of (51)Cr-EDTA (Clp(EDTA)) is widely used to determine glomerular filtration rate prior to carboplatin based chemotherapy. We have observed that many patients with ovarian cancer have elevated Clp in the early post-operative phase compared to later phases. The purpose of this study was to examine whether this observation reflects a systematic difference. We retrospectively analysed data from 53 patients who had undergone surgery for ovarian cancer. Twenty-six patients had Clp(EDTA) measured early after the operation (mean, 8 days (range, 3-16 days)) (early group), and 27 patients had Clp(EDTA) measured late post-operatively (mean, 32 days (range, 19-48 days)) (late group). Clp(EDTA) values was measured before the first, third and fifth course of chemotherapy. Additionally, age, height, weight, cancer stage, ascites and tumour histology were noted. Mean Clp(EDTA) in the early group was significantly higher than in the late group (104+/-4.4 vs 89+/-3.5 ml.min(-1) per 1.73 m(2); P =0.005). Clp(EDTA) declined significantly in the early group from the first measurement after the operation until measurement before the third course of chemotherapy but remained constant in the late group. Clp(EDTA) was not correlated to ascites, cancer stage or tumour histology. It is concluded that patients with ovarian cancer have significantly higher Clp(EDTA) in the early post-operative phase than similar patients with Clp(EDTA) measured late post-operatively.

AB - Plasma clearance of (51)Cr-EDTA (Clp(EDTA)) is widely used to determine glomerular filtration rate prior to carboplatin based chemotherapy. We have observed that many patients with ovarian cancer have elevated Clp in the early post-operative phase compared to later phases. The purpose of this study was to examine whether this observation reflects a systematic difference. We retrospectively analysed data from 53 patients who had undergone surgery for ovarian cancer. Twenty-six patients had Clp(EDTA) measured early after the operation (mean, 8 days (range, 3-16 days)) (early group), and 27 patients had Clp(EDTA) measured late post-operatively (mean, 32 days (range, 19-48 days)) (late group). Clp(EDTA) values was measured before the first, third and fifth course of chemotherapy. Additionally, age, height, weight, cancer stage, ascites and tumour histology were noted. Mean Clp(EDTA) in the early group was significantly higher than in the late group (104+/-4.4 vs 89+/-3.5 ml.min(-1) per 1.73 m(2); P =0.005). Clp(EDTA) declined significantly in the early group from the first measurement after the operation until measurement before the third course of chemotherapy but remained constant in the late group. Clp(EDTA) was not correlated to ascites, cancer stage or tumour histology. It is concluded that patients with ovarian cancer have significantly higher Clp(EDTA) in the early post-operative phase than similar patients with Clp(EDTA) measured late post-operatively.

KW - Antineoplastic Agents

KW - Antineoplastic Combined Chemotherapy Protocols/therapeutic use

KW - Ascites/diagnostic imaging

KW - Blood Specimen Collection

KW - Carboplatin/therapeutic use

KW - Chromium Radioisotopes/blood

KW - Edetic Acid/blood

KW - Female

KW - Glomerular Filtration Rate

KW - Humans

KW - Metabolic Clearance Rate

KW - Middle Aged

KW - Neoplasm Staging

KW - Ovarian Neoplasms/diagnostic imaging

KW - Postoperative Period

KW - Radionuclide Imaging

KW - Radiopharmaceuticals/blood

KW - Reproducibility of Results

KW - Retrospective Studies

KW - Sensitivity and Specificity

KW - Statistics as Topic

M3 - Journal article

VL - 23

SP - 917

EP - 920

JO - Nuclear Medicine Communications

JF - Nuclear Medicine Communications

SN - 0143-3636

IS - 9

ER -